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Sickle cell anaemia in Nigeria: a comparison between Benin and Lagos

Sickle cell anaemia in Nigeria: a comparison between Benin and Lagos
Sickle cell anaemia in Nigeria: a comparison between Benin and Lagos
The clinical and haematological features of 77 patients of Bini and 107 patients of Yoruba origin with homozygous sickle cell (SS) disease have been compared. The Bini population were generally younger and had a slightly lower incidence of alpha thalassaemia but even after correction for age and alpha thalassaemia status, this group had significantly lower HbA2 and higher HbF and MCV values. Clinically the Bini group had significantly less dactylitis and more acute chest syndrome. The decreased frequency of dactylitis is consistent with the higher HbF level in the Bini population and the mechanism of the other effects are discussed
0002-0028
101-107
Akenzua, G.
d8625d13-6e40-4333-b6b9-c61081408af0
Akinyanju, O.
a81aba07-8b99-4013-9129-f86d41cb9943
Kulozik, A.
be07930b-8ab9-4c90-8767-37bd28ef8599
Whitehead, S.
5c4273ae-23ad-4b02-b861-cdf50fd40df8
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Serjeant, B.E.
d6cf580b-27e4-4943-9696-ddf4e51b9999
Serjeant, G.
31cb7780-248d-4ec2-a4e6-602433dd514e
Akenzua, G.
d8625d13-6e40-4333-b6b9-c61081408af0
Akinyanju, O.
a81aba07-8b99-4013-9129-f86d41cb9943
Kulozik, A.
be07930b-8ab9-4c90-8767-37bd28ef8599
Whitehead, S.
5c4273ae-23ad-4b02-b861-cdf50fd40df8
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Serjeant, B.E.
d6cf580b-27e4-4943-9696-ddf4e51b9999
Serjeant, G.
31cb7780-248d-4ec2-a4e6-602433dd514e

Akenzua, G., Akinyanju, O., Kulozik, A., Whitehead, S., Morris, J.S., Serjeant, B.E. and Serjeant, G. (1994) Sickle cell anaemia in Nigeria: a comparison between Benin and Lagos. African Journal of Medical Science, 23 (2), 101-107. (PMID:7542830)

Record type: Article

Abstract

The clinical and haematological features of 77 patients of Bini and 107 patients of Yoruba origin with homozygous sickle cell (SS) disease have been compared. The Bini population were generally younger and had a slightly lower incidence of alpha thalassaemia but even after correction for age and alpha thalassaemia status, this group had significantly lower HbA2 and higher HbF and MCV values. Clinically the Bini group had significantly less dactylitis and more acute chest syndrome. The decreased frequency of dactylitis is consistent with the higher HbF level in the Bini population and the mechanism of the other effects are discussed

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Published date: 1994
Organisations: Faculty of Health Sciences

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Local EPrints ID: 365132
URI: https://eprints.soton.ac.uk/id/eprint/365132
ISSN: 0002-0028
PURE UUID: 7e0fce19-b6a6-4847-b5f1-2c1023b38e92

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Date deposited: 30 May 2014 07:45
Last modified: 18 Jul 2017 02:24

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