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Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate

Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate
Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate
Stem cells respond to nanoscale surface features, with changes in cell growth and differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical features with integrin receptors in the cells' focal adhesions alters how the cells adhere to materials surfaces, and defines cell fate through changes in both cell biochemistry and cell morphology. In this Review, we discuss how cell adhesions interact with nanotopography, and we provide insight as to how materials scientists can exploit these interactions to direct stem cell fate and to understand how the behaviour of stem cells in their niche can be controlled. We expect knowledge gained from the study of cell-nanotopography interactions to accelerate the development of next-generation stem cell culture materials and implant interfaces, and to fuel discovery of stem cell therapeutics to support regenerative therapies.
1476-1122
558-569
Dalby, Matthew J.
25dcae6a-8289-4169-abb7-c45fff0bafdc
Gadegaard, Nikolaj
bf72c3d1-e6a7-48b4-a968-c496b655bd98
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dalby, Matthew J.
25dcae6a-8289-4169-abb7-c45fff0bafdc
Gadegaard, Nikolaj
bf72c3d1-e6a7-48b4-a968-c496b655bd98
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778

Dalby, Matthew J., Gadegaard, Nikolaj and Oreffo, Richard O.C. (2014) Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate. Nature Materials, 13 (6), 558-569. (doi:10.1038/nmat3980). (PMID:24845995)

Record type: Article

Abstract

Stem cells respond to nanoscale surface features, with changes in cell growth and differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical features with integrin receptors in the cells' focal adhesions alters how the cells adhere to materials surfaces, and defines cell fate through changes in both cell biochemistry and cell morphology. In this Review, we discuss how cell adhesions interact with nanotopography, and we provide insight as to how materials scientists can exploit these interactions to direct stem cell fate and to understand how the behaviour of stem cells in their niche can be controlled. We expect knowledge gained from the study of cell-nanotopography interactions to accelerate the development of next-generation stem cell culture materials and implant interfaces, and to fuel discovery of stem cell therapeutics to support regenerative therapies.

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Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate Nature Materials Nature Publishing Group.mht - Other
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e-pub ahead of print date: 21 May 2014
Published date: 21 May 2014
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 365185
URI: http://eprints.soton.ac.uk/id/eprint/365185
ISSN: 1476-1122
PURE UUID: d1905c83-b84c-4ffd-8947-abbdf927cef1
ORCID for Richard O.C. Oreffo: ORCID iD orcid.org/0000-0001-5995-6726

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Date deposited: 27 May 2014 11:48
Last modified: 17 Dec 2019 01:53

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Contributors

Author: Matthew J. Dalby
Author: Nikolaj Gadegaard

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