Ectopic fat, insulin resistance, and nonalcoholic Fatty liver disease: implications for cardiovascular disease
Ectopic fat, insulin resistance, and nonalcoholic Fatty liver disease: implications for cardiovascular disease
Ectopic fat accumulation in the liver causes nonalcoholic fatty liver disease (NAFLD), which is the most common cause of chronic liver disease in Western countries. Ectopic liver lipid, particularly diacylglycerol, exacerbates hepatic insulin resistance, promotes systemic inflammation, and increases risk of developing both type 2 diabetes mellitus and cardiovascular disease. Increasing evidence suggests that NAFLD is an emerging risk factor for cardiovascular disease, and although there are currently no licensed treatments for NAFLD per se, current evidence suggests that statin treatment is safe in NAFLD. Presently, there is insufficient evidence to indicate that statins or other cardioprotective agents, such as angiotensin receptor blockers, are effective in treating NAFLD. In this brief narrative review, we discuss the diagnosis of NAFLD and the role of ectopic liver fat to cause insulin resistance and to increase risk of both type 2 diabetes mellitus and cardiovascular disease. For this review, PubMed was searched for articles using the key words non-alcoholic fatty liver disease or fatty liver combined with diabetes risk, cardiovascular risk, and cardiovascular mortality between 1990 and 2014. Articles published in languages other than English were excluded
1155-1161
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Targher, G.
5a842bd2-91c4-4063-b639-da6c681f3698
June 2014
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Targher, G.
5a842bd2-91c4-4063-b639-da6c681f3698
Byrne, Christopher D. and Targher, G.
(2014)
Ectopic fat, insulin resistance, and nonalcoholic Fatty liver disease: implications for cardiovascular disease.
Arteriosclerosis, Thrombosis, and Vascular Biology, 34 (6), .
(doi:10.1161/?ATVBAHA.114.303034).
(PMID:24743428)
Abstract
Ectopic fat accumulation in the liver causes nonalcoholic fatty liver disease (NAFLD), which is the most common cause of chronic liver disease in Western countries. Ectopic liver lipid, particularly diacylglycerol, exacerbates hepatic insulin resistance, promotes systemic inflammation, and increases risk of developing both type 2 diabetes mellitus and cardiovascular disease. Increasing evidence suggests that NAFLD is an emerging risk factor for cardiovascular disease, and although there are currently no licensed treatments for NAFLD per se, current evidence suggests that statin treatment is safe in NAFLD. Presently, there is insufficient evidence to indicate that statins or other cardioprotective agents, such as angiotensin receptor blockers, are effective in treating NAFLD. In this brief narrative review, we discuss the diagnosis of NAFLD and the role of ectopic liver fat to cause insulin resistance and to increase risk of both type 2 diabetes mellitus and cardiovascular disease. For this review, PubMed was searched for articles using the key words non-alcoholic fatty liver disease or fatty liver combined with diabetes risk, cardiovascular risk, and cardiovascular mortality between 1990 and 2014. Articles published in languages other than English were excluded
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Published date: June 2014
Organisations:
Human Development & Health
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Local EPrints ID: 365288
URI: http://eprints.soton.ac.uk/id/eprint/365288
ISSN: 1079-5642
PURE UUID: 9f0e724b-0bfa-46e8-bf89-067512a6e3fc
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Date deposited: 30 May 2014 14:07
Last modified: 15 Mar 2024 03:02
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G. Targher
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