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Clinical immunity to Plasmodium falciparum malaria is associated with serum antibodies to the 19-kDa C-terminal fragment of the merozoite surface antigen PfMSP-1

Clinical immunity to Plasmodium falciparum malaria is associated with serum antibodies to the 19-kDa C-terminal fragment of the merozoite surface antigen PfMSP-1
Clinical immunity to Plasmodium falciparum malaria is associated with serum antibodies to the 19-kDa C-terminal fragment of the merozoite surface antigen PfMSP-1
The development of an effective malaria vaccine depends upon identification of antigens that are targets of protective immune responses. An immunoepidemiologic approach has been used to investigate the relationship between antibody responses to a defined region of the major merozoite surface protein of Plasmodium falciparum (PfMSP-1 19) and resistance to clinical malaria in 2 populations of children from West Africa. After allowing for the confounding effects of age, antibodies to PfMSP-1 19 were shown the provide 40% protection against clinical malaria in children in Sierra Leone. In Gambian children, antibodies to one of the epidermal growth factor-like motifs of PfMSP-1 19 were strongly associated with resistance to both clinical malaria and high levels of parasitemia.
0022-1899
765-769
Egan, A.F.
b61ab242-759d-4a2f-89dc-c0ee4e1bf24e
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Barnish, G.
f4074dc3-551d-4f81-9399-ec8d95be3c04
Allen, S.
48aec8ad-441b-4cec-8bd8-c90296ed54b2
Greenwood, B.M.
64eecb64-7030-4eac-88b5-f7cf41ed45ae
Kaslow, D.C.
edd3ebc7-7981-4e2f-bdb9-856c78894835
Holder, A.A.
be2b9533-e007-41bf-899c-e463dbbf632d
Riley, E.M.
88dd64e4-7596-4016-93a8-f376dab38069
Egan, A.F.
b61ab242-759d-4a2f-89dc-c0ee4e1bf24e
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Barnish, G.
f4074dc3-551d-4f81-9399-ec8d95be3c04
Allen, S.
48aec8ad-441b-4cec-8bd8-c90296ed54b2
Greenwood, B.M.
64eecb64-7030-4eac-88b5-f7cf41ed45ae
Kaslow, D.C.
edd3ebc7-7981-4e2f-bdb9-856c78894835
Holder, A.A.
be2b9533-e007-41bf-899c-e463dbbf632d
Riley, E.M.
88dd64e4-7596-4016-93a8-f376dab38069

Egan, A.F., Morris, J.S., Barnish, G., Allen, S., Greenwood, B.M., Kaslow, D.C., Holder, A.A. and Riley, E.M. (1996) Clinical immunity to Plasmodium falciparum malaria is associated with serum antibodies to the 19-kDa C-terminal fragment of the merozoite surface antigen PfMSP-1. The Journal of Infectious Diseases, 173 (3), 765-769. (doi:10.1093/infdis/173.3.765). (PMID:8627050)

Record type: Article

Abstract

The development of an effective malaria vaccine depends upon identification of antigens that are targets of protective immune responses. An immunoepidemiologic approach has been used to investigate the relationship between antibody responses to a defined region of the major merozoite surface protein of Plasmodium falciparum (PfMSP-1 19) and resistance to clinical malaria in 2 populations of children from West Africa. After allowing for the confounding effects of age, antibodies to PfMSP-1 19 were shown the provide 40% protection against clinical malaria in children in Sierra Leone. In Gambian children, antibodies to one of the epidermal growth factor-like motifs of PfMSP-1 19 were strongly associated with resistance to both clinical malaria and high levels of parasitemia.

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Published date: 1996
Organisations: Faculty of Health Sciences

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Local EPrints ID: 365380
URI: https://eprints.soton.ac.uk/id/eprint/365380
ISSN: 0022-1899
PURE UUID: 8e49a9dd-84fa-4485-bd2d-58d3642ebcb4

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Date deposited: 03 Jun 2014 14:30
Last modified: 16 Jul 2019 21:04

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Contributors

Author: A.F. Egan
Author: J.S. Morris
Author: G. Barnish
Author: S. Allen
Author: B.M. Greenwood
Author: D.C. Kaslow
Author: A.A. Holder
Author: E.M. Riley

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