No increased prevalence of adrenocortical insufficiency in human immunodeficiency virus-associated tuberculosis

Hawken, M.P., Ojoo, J.C.O., Morris, J.S., Kariuki, E.W., Githui, W.A., Juma, E.W., Gathua, S.N., Kimari, J.N., Thiong'o, L.N., Broadbent, P., Gilks, C., Raynes, J.G., Otieno, L.S. and McAdam, K.P.W.J. (1996) No increased prevalence of adrenocortical insufficiency in human immunodeficiency virus-associated tuberculosis. Tubercle and Lung Disease, 77 (5), 444-448. (doi:10.1016/S0962-8479(96)90118-5). (PMID:8959149)

Abstract

Setting: Acute medical wards, Kenyatta National Hospital, Nairobi, Kenya.
Objective: To determine the prevalence of adrenocortical insufficiency in human immunodeficiency virus (HIV)-1 infected and non-infected patients with tuberculosis.
Design: One hundred and seventy-four patients with proven tuberculosis (90 HIV-1 positive and 84 HIV-1 negative) were assessed for adrenocortical insufficiency with a 30 min synacthen stimulation test.
Results: Fifty-one percent of those with pulmonary tuberculosis and 56% of those with extra-pulmonary tuberculosis had a subnormal cortisol response. However there was no statistically significant difference between the HIV-1 infected and non-infected patients in either group.Conclusion: While an impaired cortisol response is common in tuberculosis, it is no more prevalent in HIV-1 infected patients than non-infected patients with tuberculosis.

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