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No increased prevalence of adrenocortical insufficiency in human immunodeficiency virus-associated tuberculosis

No increased prevalence of adrenocortical insufficiency in human immunodeficiency virus-associated tuberculosis
No increased prevalence of adrenocortical insufficiency in human immunodeficiency virus-associated tuberculosis
Setting: Acute medical wards, Kenyatta National Hospital, Nairobi, Kenya.
Objective: To determine the prevalence of adrenocortical insufficiency in human immunodeficiency virus (HIV)-1 infected and non-infected patients with tuberculosis.
Design: One hundred and seventy-four patients with proven tuberculosis (90 HIV-1 positive and 84 HIV-1 negative) were assessed for adrenocortical insufficiency with a 30 min synacthen stimulation test.
Results: Fifty-one percent of those with pulmonary tuberculosis and 56% of those with extra-pulmonary tuberculosis had a subnormal cortisol response. However there was no statistically significant difference between the HIV-1 infected and non-infected patients in either group.Conclusion: While an impaired cortisol response is common in tuberculosis, it is no more prevalent in HIV-1 infected patients than non-infected patients with tuberculosis.
0962-8479
444-448
Hawken, M.P.
8b55fc1e-c3a6-467f-b6b8-5f2195a9a9f8
Ojoo, J.C.O.
a59e3a6a-ed69-4562-822a-5f1b6f1abc96
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Kariuki, E.W.
16393d2a-f94e-42fc-8763-8a0287303f67
Githui, W.A.
14d27400-5e82-46ac-a533-f0cec0a135fd
Juma, E.W.
5c3e2c85-eb8f-418f-9cf8-2ca75214be4c
Gathua, S.N.
acf8cf6a-cffc-4804-99be-4d8d1938266d
Kimari, J.N.
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Thiong'o, L.N.
e29178f1-2563-4b7f-a971-2fe6ad96bc4c
Broadbent, P.
0a224fb0-cf6c-407e-a64a-f154a85665f5
Gilks, C.
45c235a6-fc8d-4aa8-aeb7-564c338e5796
Raynes, J.G.
5ab955a0-9290-4ac9-a3a2-d78b2ab2d2be
Otieno, L.S.
48e5eda4-3bb6-43fb-a59a-2249752a1dfa
McAdam, K.P.W.J.
a1aa3631-c26b-4755-a154-7a5cb3cac2d5
Hawken, M.P.
8b55fc1e-c3a6-467f-b6b8-5f2195a9a9f8
Ojoo, J.C.O.
a59e3a6a-ed69-4562-822a-5f1b6f1abc96
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Kariuki, E.W.
16393d2a-f94e-42fc-8763-8a0287303f67
Githui, W.A.
14d27400-5e82-46ac-a533-f0cec0a135fd
Juma, E.W.
5c3e2c85-eb8f-418f-9cf8-2ca75214be4c
Gathua, S.N.
acf8cf6a-cffc-4804-99be-4d8d1938266d
Kimari, J.N.
07f6d56a-67af-418d-bd10-b728f7bf8cee
Thiong'o, L.N.
e29178f1-2563-4b7f-a971-2fe6ad96bc4c
Broadbent, P.
0a224fb0-cf6c-407e-a64a-f154a85665f5
Gilks, C.
45c235a6-fc8d-4aa8-aeb7-564c338e5796
Raynes, J.G.
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Otieno, L.S.
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McAdam, K.P.W.J.
a1aa3631-c26b-4755-a154-7a5cb3cac2d5

Hawken, M.P., Ojoo, J.C.O., Morris, J.S., Kariuki, E.W., Githui, W.A., Juma, E.W., Gathua, S.N., Kimari, J.N., Thiong'o, L.N., Broadbent, P., Gilks, C., Raynes, J.G., Otieno, L.S. and McAdam, K.P.W.J. (1996) No increased prevalence of adrenocortical insufficiency in human immunodeficiency virus-associated tuberculosis. Tubercle and Lung Disease, 77 (5), 444-448. (doi:10.1016/S0962-8479(96)90118-5). (PMID:8959149)

Record type: Article

Abstract

Setting: Acute medical wards, Kenyatta National Hospital, Nairobi, Kenya.
Objective: To determine the prevalence of adrenocortical insufficiency in human immunodeficiency virus (HIV)-1 infected and non-infected patients with tuberculosis.
Design: One hundred and seventy-four patients with proven tuberculosis (90 HIV-1 positive and 84 HIV-1 negative) were assessed for adrenocortical insufficiency with a 30 min synacthen stimulation test.
Results: Fifty-one percent of those with pulmonary tuberculosis and 56% of those with extra-pulmonary tuberculosis had a subnormal cortisol response. However there was no statistically significant difference between the HIV-1 infected and non-infected patients in either group.Conclusion: While an impaired cortisol response is common in tuberculosis, it is no more prevalent in HIV-1 infected patients than non-infected patients with tuberculosis.

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Published date: 1996
Organisations: Faculty of Health Sciences

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Local EPrints ID: 365383
URI: http://eprints.soton.ac.uk/id/eprint/365383
ISSN: 0962-8479
PURE UUID: 33c5e892-6b4f-4e69-b998-dbefba754299

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Date deposited: 03 Jun 2014 15:02
Last modified: 14 Mar 2024 16:52

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Contributors

Author: M.P. Hawken
Author: J.C.O. Ojoo
Author: J.S. Morris
Author: E.W. Kariuki
Author: W.A. Githui
Author: E.W. Juma
Author: S.N. Gathua
Author: J.N. Kimari
Author: L.N. Thiong'o
Author: P. Broadbent
Author: C. Gilks
Author: J.G. Raynes
Author: L.S. Otieno
Author: K.P.W.J. McAdam

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