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Association of malaria parasite population structure, HLA, and immunulogical antagonism

Association of malaria parasite population structure, HLA, and immunulogical antagonism
Association of malaria parasite population structure, HLA, and immunulogical antagonism
Host-parasite coevolution has been likened to a molecular arms race, with particular parasite genes evolving to evade specific host defenses. Study of the variants of an antigenic epitope of Plasmodium falciparum that induces a cytotoxic T cell response supports this view. In African children with malaria, the variants present are influenced by the presence of a human leukocyte antigen (HLA) type that restricts the immune response to this epitope. The distribution of parasite variants may be further influenced by the ability of cohabiting parasite strains to facilitate each other's survival by down-regulating cellular immune responses, using altered peptide ligand antagonism.
1173-1177
Gilbert, S.C.
59445e39-22af-490c-ab8e-1d4fc27b9828
Plebanski, M.
107e6993-565b-4cf5-becd-62d73e6c7b5a
Gupta, S.
32658b41-cb78-4f2d-8848-f4b2e92e4fc5
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Cox, M.
40f0c88f-0295-47ba-a1db-df693592ba73
Aidoo, M.
33dbabeb-8e98-4a6f-9f19-87dc77d8a5ea
Kwiatowski, D.
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Greenwood, B.M.
64eecb64-7030-4eac-88b5-f7cf41ed45ae
Whittle, H.C.
4c2d328e-d2a3-4393-ba3a-11fb7a63c4ca
Hill, A.V.
d9af9241-5268-422d-928e-d76e7ef9b121
Gilbert, S.C.
59445e39-22af-490c-ab8e-1d4fc27b9828
Plebanski, M.
107e6993-565b-4cf5-becd-62d73e6c7b5a
Gupta, S.
32658b41-cb78-4f2d-8848-f4b2e92e4fc5
Morris, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Cox, M.
40f0c88f-0295-47ba-a1db-df693592ba73
Aidoo, M.
33dbabeb-8e98-4a6f-9f19-87dc77d8a5ea
Kwiatowski, D.
6d781abd-6d74-47b9-a583-0c9c517bda7d
Greenwood, B.M.
64eecb64-7030-4eac-88b5-f7cf41ed45ae
Whittle, H.C.
4c2d328e-d2a3-4393-ba3a-11fb7a63c4ca
Hill, A.V.
d9af9241-5268-422d-928e-d76e7ef9b121

Gilbert, S.C., Plebanski, M., Gupta, S., Morris, J.S., Cox, M., Aidoo, M., Kwiatowski, D., Greenwood, B.M., Whittle, H.C. and Hill, A.V. (1998) Association of malaria parasite population structure, HLA, and immunulogical antagonism. Science, 279 (5354), 1173-1177. (doi:10.1126/science.279.5354.1173). (PMID:9469800)

Record type: Article

Abstract

Host-parasite coevolution has been likened to a molecular arms race, with particular parasite genes evolving to evade specific host defenses. Study of the variants of an antigenic epitope of Plasmodium falciparum that induces a cytotoxic T cell response supports this view. In African children with malaria, the variants present are influenced by the presence of a human leukocyte antigen (HLA) type that restricts the immune response to this epitope. The distribution of parasite variants may be further influenced by the ability of cohabiting parasite strains to facilitate each other's survival by down-regulating cellular immune responses, using altered peptide ligand antagonism.

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Published date: 1998
Organisations: Faculty of Health Sciences

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Local EPrints ID: 365389
URI: http://eprints.soton.ac.uk/id/eprint/365389
PURE UUID: 557c1b11-7a1b-4b9c-be8f-debb881eca28

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Date deposited: 03 Jun 2014 15:20
Last modified: 16 Jul 2019 21:04

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Contributors

Author: S.C. Gilbert
Author: M. Plebanski
Author: S. Gupta
Author: J.S. Morris
Author: M. Cox
Author: M. Aidoo
Author: D. Kwiatowski
Author: B.M. Greenwood
Author: H.C. Whittle
Author: A.V. Hill

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