The University of Southampton
University of Southampton Institutional Repository

TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early stage breast cancer

TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early stage breast cancer
TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early stage breast cancer
Recent studies suggest that normal tissue radiosensitivity is influenced by single nucleotide polymorphisms (SNPs) in certain genes. In order to seek a confirmation of these findings, this study investigated SNPs in genes TGFB1 (position -509, codon 10 and codon 25), SOD2 (codon 16), XRCC1 (codon 399), XRCC3 (codon 241), APEX (codon 148) and ATM (codon 1853) in 26 breast cancer patients with marked changes in breast appearance after radiotherapy and 26 matched controls. Statistically significant associations were found between the TGFB1 codon 10 Pro allele (P=0.005) as well as the TGFB1 position -509 T allele (P=0.018) and increased risk of altered breast appearance. No significant associations were found for the remaining SNPs.
0167-8140
18-21
Andreassen, C.N.
6f736d8e-1edd-4f57-b0bb-1b1d957a619f
Alsner, J.
b783b124-e385-4eef-9a3d-168f834915b9
Overgaard, J.
4a4a8c38-db8a-403f-8ac4-979c0bf8f34c
Herskind, C.
5e31c184-defb-4b6e-ae6d-9e5fef25097e
Haviland, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Owen, R.
f7aa4dfb-4c7b-4718-8600-83a835fa9fa9
Homewood, J.
95830369-2ba6-459e-b9d1-10f5e9611e7a
Bliss, J.
43c94e57-7e4c-4959-979c-c938b5ec2a3b
Yarnold, J.
0003b4fd-a371-4258-890f-ffd3d0b5c3a9
Andreassen, C.N.
6f736d8e-1edd-4f57-b0bb-1b1d957a619f
Alsner, J.
b783b124-e385-4eef-9a3d-168f834915b9
Overgaard, J.
4a4a8c38-db8a-403f-8ac4-979c0bf8f34c
Herskind, C.
5e31c184-defb-4b6e-ae6d-9e5fef25097e
Haviland, J.S.
569aa43b-15bd-4e9d-b4a5-e68a84334cfe
Owen, R.
f7aa4dfb-4c7b-4718-8600-83a835fa9fa9
Homewood, J.
95830369-2ba6-459e-b9d1-10f5e9611e7a
Bliss, J.
43c94e57-7e4c-4959-979c-c938b5ec2a3b
Yarnold, J.
0003b4fd-a371-4258-890f-ffd3d0b5c3a9

Andreassen, C.N., Alsner, J., Overgaard, J., Herskind, C., Haviland, J.S., Owen, R., Homewood, J., Bliss, J. and Yarnold, J. (2005) TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early stage breast cancer. Radiotherapy and Oncology, 75 (1), 18-21. (doi:10.1016/j.radonc.2004.12.012). (PMID:15878096)

Record type: Article

Abstract

Recent studies suggest that normal tissue radiosensitivity is influenced by single nucleotide polymorphisms (SNPs) in certain genes. In order to seek a confirmation of these findings, this study investigated SNPs in genes TGFB1 (position -509, codon 10 and codon 25), SOD2 (codon 16), XRCC1 (codon 399), XRCC3 (codon 241), APEX (codon 148) and ATM (codon 1853) in 26 breast cancer patients with marked changes in breast appearance after radiotherapy and 26 matched controls. Statistically significant associations were found between the TGFB1 codon 10 Pro allele (P=0.005) as well as the TGFB1 position -509 T allele (P=0.018) and increased risk of altered breast appearance. No significant associations were found for the remaining SNPs.

PDF
TGFB1 polymorphisms are associated with risk of late normal tissue complications - Andreassen et al 2005.pdf - Other
Download (71kB)

More information

Published date: 2005
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 365435
URI: https://eprints.soton.ac.uk/id/eprint/365435
ISSN: 0167-8140
PURE UUID: 174754da-1677-4783-9269-ac2a1bd49099

Catalogue record

Date deposited: 05 Jun 2014 10:19
Last modified: 18 Jul 2017 02:21

Export record

Altmetrics

Contributors

Author: C.N. Andreassen
Author: J. Alsner
Author: J. Overgaard
Author: C. Herskind
Author: J.S. Haviland
Author: R. Owen
Author: J. Homewood
Author: J. Bliss
Author: J. Yarnold

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×