TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early stage breast cancer
TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early stage breast cancer
Recent studies suggest that normal tissue radiosensitivity is influenced by single nucleotide polymorphisms (SNPs) in certain genes. In order to seek a confirmation of these findings, this study investigated SNPs in genes TGFB1 (position -509, codon 10 and codon 25), SOD2 (codon 16), XRCC1 (codon 399), XRCC3 (codon 241), APEX (codon 148) and ATM (codon 1853) in 26 breast cancer patients with marked changes in breast appearance after radiotherapy and 26 matched controls. Statistically significant associations were found between the TGFB1 codon 10 Pro allele (P=0.005) as well as the TGFB1 position -509 T allele (P=0.018) and increased risk of altered breast appearance. No significant associations were found for the remaining SNPs.
18-21
Andreassen, C.N.
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Alsner, J.
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Overgaard, J.
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Herskind, C.
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Haviland, J.S.
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Owen, R.
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Homewood, J.
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Bliss, J.
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Yarnold, J.
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2005
Andreassen, C.N.
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Alsner, J.
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Overgaard, J.
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Herskind, C.
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Haviland, J.S.
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Owen, R.
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Homewood, J.
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Bliss, J.
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Yarnold, J.
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Andreassen, C.N., Alsner, J., Overgaard, J., Herskind, C., Haviland, J.S., Owen, R., Homewood, J., Bliss, J. and Yarnold, J.
(2005)
TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early stage breast cancer.
Radiotherapy and Oncology, 75 (1), .
(doi:10.1016/j.radonc.2004.12.012).
(PMID:15878096)
Abstract
Recent studies suggest that normal tissue radiosensitivity is influenced by single nucleotide polymorphisms (SNPs) in certain genes. In order to seek a confirmation of these findings, this study investigated SNPs in genes TGFB1 (position -509, codon 10 and codon 25), SOD2 (codon 16), XRCC1 (codon 399), XRCC3 (codon 241), APEX (codon 148) and ATM (codon 1853) in 26 breast cancer patients with marked changes in breast appearance after radiotherapy and 26 matched controls. Statistically significant associations were found between the TGFB1 codon 10 Pro allele (P=0.005) as well as the TGFB1 position -509 T allele (P=0.018) and increased risk of altered breast appearance. No significant associations were found for the remaining SNPs.
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TGFB1 polymorphisms are associated with risk of late normal tissue complications - Andreassen et al 2005.pdf
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Published date: 2005
Organisations:
Faculty of Health Sciences
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Local EPrints ID: 365435
URI: http://eprints.soton.ac.uk/id/eprint/365435
ISSN: 0167-8140
PURE UUID: 174754da-1677-4783-9269-ac2a1bd49099
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Date deposited: 05 Jun 2014 10:19
Last modified: 14 Mar 2024 16:53
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Author:
C.N. Andreassen
Author:
J. Alsner
Author:
J. Overgaard
Author:
C. Herskind
Author:
J.S. Haviland
Author:
R. Owen
Author:
J. Homewood
Author:
J. Bliss
Author:
J. Yarnold
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