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Inflammation is associated with a worsening of presbycusis: evidence from the MRC national study of hearing

Inflammation is associated with a worsening of presbycusis: evidence from the MRC national study of hearing
Inflammation is associated with a worsening of presbycusis: evidence from the MRC national study of hearing
Objective: Inflammaging, a state of chronic inflammation in the elderly, is now thought to be a key element of the ageing process and contributor to age-related disease. In a previously published study, we identified a significant association between inflammation levels and severity of presbycusis among individuals aged 63 to 73 ('younger old") within an available audiometric range 0.5 to 4 kHz. Our aim was to see if this association would be identified among participants in the MRC national study of hearing, and whether the strength of the association would increase with greater age, or for very low or very high audiometric frequencies. Design: Cross-sectional analysis of cohort data. Study sample: Three hundred and sixty community-dwelling adults age 60 years and over, representing all those with white blood cell count and audiometric data available. Results: A significant independent association between (higher) WBC and (worse) hearing level was identified. This effect increased with age. The strongest association was among those over 75, for whom average hearing threshold levels among those with lower WBC was 17 dB better than those with higher WBC. Conclusions: The current findings support an association between inflammaging (a condition potentially amenable to pharmacological treatment or lifestyle management) and presbycusis
presbycusis, age-related hearing loss, bio-markers, inflammation
469-475
Verschuur, C.A.
5e15ee1c-3a44-4dbe-ad43-ec3b50111e41
Agyemang-Prempeh, A.
9aa542a7-da99-45ba-acc7-08b35a389002
Newman, Tracey A.
322290cb-2e9c-445d-a047-00b1bea39a25
Verschuur, C.A.
5e15ee1c-3a44-4dbe-ad43-ec3b50111e41
Agyemang-Prempeh, A.
9aa542a7-da99-45ba-acc7-08b35a389002
Newman, Tracey A.
322290cb-2e9c-445d-a047-00b1bea39a25

Verschuur, C.A., Agyemang-Prempeh, A. and Newman, Tracey A. (2014) Inflammation is associated with a worsening of presbycusis: evidence from the MRC national study of hearing. International Journal of Audiology, 53 (7), 469-475. (doi:10.3109/14992027.2014.891057). (PMID:24679110)

Record type: Article

Abstract

Objective: Inflammaging, a state of chronic inflammation in the elderly, is now thought to be a key element of the ageing process and contributor to age-related disease. In a previously published study, we identified a significant association between inflammation levels and severity of presbycusis among individuals aged 63 to 73 ('younger old") within an available audiometric range 0.5 to 4 kHz. Our aim was to see if this association would be identified among participants in the MRC national study of hearing, and whether the strength of the association would increase with greater age, or for very low or very high audiometric frequencies. Design: Cross-sectional analysis of cohort data. Study sample: Three hundred and sixty community-dwelling adults age 60 years and over, representing all those with white blood cell count and audiometric data available. Results: A significant independent association between (higher) WBC and (worse) hearing level was identified. This effect increased with age. The strongest association was among those over 75, for whom average hearing threshold levels among those with lower WBC was 17 dB better than those with higher WBC. Conclusions: The current findings support an association between inflammaging (a condition potentially amenable to pharmacological treatment or lifestyle management) and presbycusis

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e-pub ahead of print date: 28 March 2014
Published date: July 2014
Additional Information: It is estimated that nearly 2 billion people world-wide will develop age-related hearing loss, with impacts on social and cognitive functioning and associated increased risks of co-morbidity including dementia. Our study identified a clear link between chronic age-related systemic inflammation and the progression of hearing loss. A particular novel finding was that this relationship increases with age. This finding indicates that lifestyle or medical interventions to manage chronic inflammation can reduce the progression of hearing loss in the elderly. This opens up new avenues in slowing down or preventing the development of hearing loss.
Keywords: presbycusis, age-related hearing loss, bio-markers, inflammation
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 365549
URI: http://eprints.soton.ac.uk/id/eprint/365549
PURE UUID: 1c4d272f-ca9d-4d03-bfe1-9387b32ec888
ORCID for Tracey A. Newman: ORCID iD orcid.org/0000-0002-3727-9258

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Date deposited: 10 Jun 2014 12:02
Last modified: 18 Feb 2021 16:46

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Contributors

Author: C.A. Verschuur
Author: A. Agyemang-Prempeh

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