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A highly sensitive electrochemical genosensor based on Co-porphyrin-labelled DNA

A highly sensitive electrochemical genosensor based on Co-porphyrin-labelled DNA
A highly sensitive electrochemical genosensor based on Co-porphyrin-labelled DNA
We report the use of Co-porphyrins as electrochemical tags for a highly sensitive and selective genosensor. An avian influenza virus-based DNA sequence characteristic of H5N1 was detected at femtomolar levels from competing non-complementary sequences through hybridisation with the labeled DNA.
1359-7345
4196-4199
Grabowska, Iwona
e0525d0f-69ee-49a9-8fa2-036f0d7d840a
Singleton, Daniel G.
d05cfb21-47bf-463a-8bd5-ae112cdc5773
Stachyra, Anna
8343bd83-dee8-489e-a77e-27dfd2fc8836
Góra-Sochacka, Anna
d2547e98-b9fd-4f9e-a598-cc9e2b02026f
Sirko, Agnieszka
c5a32e6e-08fa-4c4d-9696-cb7f6c7aa764
Zagórski-Ostoja, Włodzimierz
e4110629-ee17-49a8-ac31-f2ad98ff4d20
Radecka, Hanna
3c2bd9a8-83a6-4f78-8cde-de14e4b401a5
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
Radecki, Jerzy
8996c0ab-2014-45ae-b828-25c5b2f05b4b
Grabowska, Iwona
e0525d0f-69ee-49a9-8fa2-036f0d7d840a
Singleton, Daniel G.
d05cfb21-47bf-463a-8bd5-ae112cdc5773
Stachyra, Anna
8343bd83-dee8-489e-a77e-27dfd2fc8836
Góra-Sochacka, Anna
d2547e98-b9fd-4f9e-a598-cc9e2b02026f
Sirko, Agnieszka
c5a32e6e-08fa-4c4d-9696-cb7f6c7aa764
Zagórski-Ostoja, Włodzimierz
e4110629-ee17-49a8-ac31-f2ad98ff4d20
Radecka, Hanna
3c2bd9a8-83a6-4f78-8cde-de14e4b401a5
Stulz, Eugen
9a6c04cf-32ca-442b-9281-bbf3d23c622d
Radecki, Jerzy
8996c0ab-2014-45ae-b828-25c5b2f05b4b

Grabowska, Iwona, Singleton, Daniel G., Stachyra, Anna, Góra-Sochacka, Anna, Sirko, Agnieszka, Zagórski-Ostoja, Włodzimierz, Radecka, Hanna, Stulz, Eugen and Radecki, Jerzy (2014) A highly sensitive electrochemical genosensor based on Co-porphyrin-labelled DNA. Chemical Communications, 50 (32), 4196-4199. (doi:10.1039/c4cc00172a).

Record type: Article

Abstract

We report the use of Co-porphyrins as electrochemical tags for a highly sensitive and selective genosensor. An avian influenza virus-based DNA sequence characteristic of H5N1 was detected at femtomolar levels from competing non-complementary sequences through hybridisation with the labeled DNA.

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e-pub ahead of print date: 3 March 2014
Published date: 25 April 2014
Organisations: Chemistry
Learn more about Chemistry research

Identifiers

Local EPrints ID: 365634
URI: http://eprints.soton.ac.uk/id/eprint/365634
DOI: doi:10.1039/c4cc00172a
ISSN: 1359-7345
PURE UUID: e38b7433-8f51-4831-ac6a-0bee52c95c24
ORCID for Eugen Stulz: ORCID iD orcid.org/0000-0002-5302-2276

Catalogue record

Date deposited: 11 Jun 2014 11:33
Last modified: 15 Mar 2024 03:26

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Contributors

Author: Iwona Grabowska
Author: Daniel G. Singleton
Author: Anna Stachyra
Author: Anna Góra-Sochacka
Author: Agnieszka Sirko
Author: Włodzimierz Zagórski-Ostoja
Author: Hanna Radecka
Author: Eugen Stulz ORCID iD
Author: Jerzy Radecki

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