Serum total hCGβ level is an independent prognostic factor in transitional cell carcinoma of the urothelial tract
Serum total hCGβ level is an independent prognostic factor in transitional cell carcinoma of the urothelial tract
Background: serum total human chorionic gonadotrophin β subunit (hCGβ) level might have prognostic value in urothelial transitional cell carcinoma (TCC) but has not been investigated for independence from other prognostic variables.
Methods: we utilised a clinical database of patients receiving chemotherapy between 2005 and 2011 for urothelial TCC and an independent cohort of radical cystectomy patients for validation purposes. Prognostic variables were tested by univariate Kaplan-Meier analyses and log-rank tests. Statistically significant variables were then assessed by multivariate Cox regression. Total hCGβ level was dichotomised at < vs ≥2 IU l-1.
Results: a total of 235 chemotherapy patients were eligible. For neoadjuvant chemotherapy, established prognostic factors including low ECOG performance status, normal haemoglobin, lower T stage and suitability for cisplatin-based chemotherapy were associated with favourable survival in univariate analyses. In addition, low hCGβ level was favourable when assessed either before (median survival not reached vs 1.86 years, P=0.001) or on completion of chemotherapy (4.27 vs 0.42 years, P=0.000002). This was confirmed in multivariate analyses and in patients receiving first-and second-line palliative chemotherapy, and in a radical cystectomy validation set.
Conclusions: serum total hCGβ level is an independent prognostic factor in patients receiving chemotherapy for urothelial TCC in both curative and palliative settings.
chemotherapy, cystectomy, hCGβ, prognosis, transitional cell carcinoma, urothelial carcinoma
1759-1766
Douglas, J.
113c1170-c37f-46bc-9d1c-38843b080abe
Sharp, A.
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Chau, C.
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Head, J.
d3a0091d-aa75-49f1-9649-ff47809758fd
Drake, T.
18c31aab-1752-4af4-951b-e1a24ce82ccf
Wheater, M.
3691c3d8-8589-4693-a0dc-c6a8648cd7df
Geldart, T.
829fdbee-84dd-4825-b5eb-0e6e859ba9ff
Mead, G.
a01f4764-abab-4ccb-804f-0b6f8d4d7696
Crabb, S.J.
bcd1b566-7677-4f81-8429-3ab0e85f8373
1 April 2014
Douglas, J.
113c1170-c37f-46bc-9d1c-38843b080abe
Sharp, A.
9f94bdc2-3c1c-4520-b874-b8ac8b989512
Chau, C.
f3b0e065-b288-488a-bbb3-3ddf8166b6fa
Head, J.
d3a0091d-aa75-49f1-9649-ff47809758fd
Drake, T.
18c31aab-1752-4af4-951b-e1a24ce82ccf
Wheater, M.
3691c3d8-8589-4693-a0dc-c6a8648cd7df
Geldart, T.
829fdbee-84dd-4825-b5eb-0e6e859ba9ff
Mead, G.
a01f4764-abab-4ccb-804f-0b6f8d4d7696
Crabb, S.J.
bcd1b566-7677-4f81-8429-3ab0e85f8373
Douglas, J., Sharp, A., Chau, C., Head, J., Drake, T., Wheater, M., Geldart, T., Mead, G. and Crabb, S.J.
(2014)
Serum total hCGβ level is an independent prognostic factor in transitional cell carcinoma of the urothelial tract.
British Journal of Cancer, 110 (7), .
(doi:10.1038/bjc.2014.89).
(PMID:24556622)
Abstract
Background: serum total human chorionic gonadotrophin β subunit (hCGβ) level might have prognostic value in urothelial transitional cell carcinoma (TCC) but has not been investigated for independence from other prognostic variables.
Methods: we utilised a clinical database of patients receiving chemotherapy between 2005 and 2011 for urothelial TCC and an independent cohort of radical cystectomy patients for validation purposes. Prognostic variables were tested by univariate Kaplan-Meier analyses and log-rank tests. Statistically significant variables were then assessed by multivariate Cox regression. Total hCGβ level was dichotomised at < vs ≥2 IU l-1.
Results: a total of 235 chemotherapy patients were eligible. For neoadjuvant chemotherapy, established prognostic factors including low ECOG performance status, normal haemoglobin, lower T stage and suitability for cisplatin-based chemotherapy were associated with favourable survival in univariate analyses. In addition, low hCGβ level was favourable when assessed either before (median survival not reached vs 1.86 years, P=0.001) or on completion of chemotherapy (4.27 vs 0.42 years, P=0.000002). This was confirmed in multivariate analyses and in patients receiving first-and second-line palliative chemotherapy, and in a radical cystectomy validation set.
Conclusions: serum total hCGβ level is an independent prognostic factor in patients receiving chemotherapy for urothelial TCC in both curative and palliative settings.
Text
bjc201489
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More information
Accepted/In Press date: 23 January 2014
e-pub ahead of print date: 20 February 2014
Published date: 1 April 2014
Additional Information:
01 April 2014 This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication
Keywords:
chemotherapy, cystectomy, hCGβ, prognosis, transitional cell carcinoma, urothelial carcinoma
Organisations:
Cancer Sciences
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Local EPrints ID: 365798
URI: http://eprints.soton.ac.uk/id/eprint/365798
ISSN: 0007-0920
PURE UUID: 3855dde7-9d68-451c-a695-2ca4ad6874d5
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Date deposited: 19 Jun 2014 10:18
Last modified: 12 Jul 2024 01:41
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Author:
J. Douglas
Author:
A. Sharp
Author:
C. Chau
Author:
J. Head
Author:
T. Drake
Author:
M. Wheater
Author:
T. Geldart
Author:
G. Mead
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