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Serum total hCGβ level is an independent prognostic factor in transitional cell carcinoma of the urothelial tract

Serum total hCGβ level is an independent prognostic factor in transitional cell carcinoma of the urothelial tract
Serum total hCGβ level is an independent prognostic factor in transitional cell carcinoma of the urothelial tract
Background:serum total human chorionic gonadotrophin ? subunit (hCG?) level might have prognostic value in urothelial transitional cell carcinoma (TCC) but has not been investigated for independence from other prognostic variables.

Methods: we utilised a clinical database of patients receiving chemotherapy between 2005 and 2011 for urothelial TCC and an independent cohort of radical cystectomy patients for validation purposes. Prognostic variables were tested by univariate Kaplan–Meier analyses and log-rank tests. Statistically significant variables were then assessed by multivariate Cox regression. Total hCG? level was dichotomised at < vs greater than or equal to2?IU?l?1.

Results: a total of 235 chemotherapy patients were eligible. For neoadjuvant chemotherapy, established prognostic factors including low ECOG performance status, normal haemoglobin, lower T stage and suitability for cisplatin-based chemotherapy were associated with favourable survival in univariate analyses. In addition, low hCG? level was favourable when assessed either before (median survival not reached vs 1.86 years, P=0.001) or on completion of chemotherapy (4.27 vs 0.42 years, P=0.000002). This was confirmed in multivariate analyses and in patients receiving first- and second-line palliative chemotherapy, and in a radical cystectomy validation set.

Conclusions: serum total hCG? level is an independent prognostic factor in patients receiving chemotherapy for urothelial TCC in both curative and palliative settings
hCG?, chemotherapy, cystectomy, prognosis, transitional cell carcinoma, urothelial carcinoma
0007-0920
1759-1766
Douglas, J.
060a8293-4c69-46a6-953e-9333d20c61f3
Sharp, A.
9f94bdc2-3c1c-4520-b874-b8ac8b989512
Chau, C.
bc5b21b2-4974-4992-806f-61e90fc5ea63
Head, J.
d3a0091d-aa75-49f1-9649-ff47809758fd
Drake, T.
18c31aab-1752-4af4-951b-e1a24ce82ccf
Wheater, M.
85400f31-13b9-4327-b52e-c4519be149d9
Geldart, T.
829fdbee-84dd-4825-b5eb-0e6e859ba9ff
Mead, G.
a01f4764-abab-4ccb-804f-0b6f8d4d7696
Crabb, S.J.
bcd1b566-7677-4f81-8429-3ab0e85f8373
Douglas, J.
060a8293-4c69-46a6-953e-9333d20c61f3
Sharp, A.
9f94bdc2-3c1c-4520-b874-b8ac8b989512
Chau, C.
bc5b21b2-4974-4992-806f-61e90fc5ea63
Head, J.
d3a0091d-aa75-49f1-9649-ff47809758fd
Drake, T.
18c31aab-1752-4af4-951b-e1a24ce82ccf
Wheater, M.
85400f31-13b9-4327-b52e-c4519be149d9
Geldart, T.
829fdbee-84dd-4825-b5eb-0e6e859ba9ff
Mead, G.
a01f4764-abab-4ccb-804f-0b6f8d4d7696
Crabb, S.J.
bcd1b566-7677-4f81-8429-3ab0e85f8373

Douglas, J., Sharp, A., Chau, C., Head, J., Drake, T., Wheater, M., Geldart, T., Mead, G. and Crabb, S.J. (2014) Serum total hCGβ level is an independent prognostic factor in transitional cell carcinoma of the urothelial tract. British Journal of Cancer, 110 (7), 1759-1766. (doi:10.1038/bjc.2014.89). (PMID:24556622)

Record type: Article

Abstract

Background:serum total human chorionic gonadotrophin ? subunit (hCG?) level might have prognostic value in urothelial transitional cell carcinoma (TCC) but has not been investigated for independence from other prognostic variables.

Methods: we utilised a clinical database of patients receiving chemotherapy between 2005 and 2011 for urothelial TCC and an independent cohort of radical cystectomy patients for validation purposes. Prognostic variables were tested by univariate Kaplan–Meier analyses and log-rank tests. Statistically significant variables were then assessed by multivariate Cox regression. Total hCG? level was dichotomised at < vs greater than or equal to2?IU?l?1.

Results: a total of 235 chemotherapy patients were eligible. For neoadjuvant chemotherapy, established prognostic factors including low ECOG performance status, normal haemoglobin, lower T stage and suitability for cisplatin-based chemotherapy were associated with favourable survival in univariate analyses. In addition, low hCG? level was favourable when assessed either before (median survival not reached vs 1.86 years, P=0.001) or on completion of chemotherapy (4.27 vs 0.42 years, P=0.000002). This was confirmed in multivariate analyses and in patients receiving first- and second-line palliative chemotherapy, and in a radical cystectomy validation set.

Conclusions: serum total hCG? level is an independent prognostic factor in patients receiving chemotherapy for urothelial TCC in both curative and palliative settings

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More information

e-pub ahead of print date: February 2014
Published date: April 2014
Keywords: hCG?, chemotherapy, cystectomy, prognosis, transitional cell carcinoma, urothelial carcinoma
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 365798
URI: http://eprints.soton.ac.uk/id/eprint/365798
ISSN: 0007-0920
PURE UUID: 3855dde7-9d68-451c-a695-2ca4ad6874d5
ORCID for S.J. Crabb: ORCID iD orcid.org/0000-0003-3521-9064

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Date deposited: 19 Jun 2014 10:18
Last modified: 15 Mar 2024 03:16

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Contributors

Author: J. Douglas
Author: A. Sharp
Author: C. Chau
Author: J. Head
Author: T. Drake
Author: M. Wheater
Author: T. Geldart
Author: G. Mead
Author: S.J. Crabb ORCID iD

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