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Maternal adiposity and blood pressure in pregnancy: varying relations by ethnicity and gestational diabetes

Maternal adiposity and blood pressure in pregnancy: varying relations by ethnicity and gestational diabetes
Maternal adiposity and blood pressure in pregnancy: varying relations by ethnicity and gestational diabetes


Objective:

Greater maternal adiposity is a potentially modifiable risk factor for elevated blood pressure during pregnancy; however, the association has been little studied in Asian populations, and no study has evaluated potential differences in the adiposity-blood pressure relation between ethnic groups or interaction with gestational diabetes.

Methods:

We performed a cross-sectional evaluation of a Singapore mother-offspring cohort comprising 799 pregnant Chinese, Malay and Indian women. Data on body weight, height, skinfold thickness and glycaemia (oral glucose tolerance test) were collected during the 2nd trimester; peripheral SBP and DBP were measured using an oscillometric device and central pressures by noninvasive radial applanation tonometry. The associations between adiposity measures BMI and sum of skinfold thickness and blood pressure outcomes were examined by linear regression with adjustment for potential confounders.

Results:

Higher maternal BMI was associated with elevated peripheral and central pressures: the increases in pressure (mmHg) for each kg/m2 increase in BMI were 1.19 (95% confidence interval, 1.03–1.36) for peripheral SBP, 0.76 (0.63–0.89) for peripheral DBP, 1.02 (0.87–1.17) for central systolic pressure and 0.26 (0.16–0.37) for central pulse pressure. The associations were generally stronger in Chinese women (P-interaction?=?0.03 for central pulse pressure) and individuals with gestational diabetes (P-interaction?=?0.03 for DBP and P-interaction?=?0.046 for central systolic pressure). Similar patterns of results were found when using skinfold thickness as the measure of adiposity.

Conclusion:

Maternal adiposity is associated with higher peripheral and central blood pressures during pregnancy. Stronger associations in Chinese women and individuals with gestational diabetes warrant further investigation.
0263-6352
857-864
Lim, W.Y.
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Kwek, K.
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Chong, Y.S.
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Lee, Y.S.
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Yap, F.
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Chan, Y.H.
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Godfrey, K.M.
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Gluckman, P.D.
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Saw, S.M.
0684517e-f27e-49f0-98c3-7630e8fd1bbd
Pan, A.
fef1894b-9c4e-470b-a8c4-6e33322ed8ce
Lim, W.Y.
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Kwek, K.
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Chong, Y.S.
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Lee, Y.S.
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Yap, F.
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Chan, Y.H.
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Godfrey, K.M.
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Gluckman, P.D.
492295c0-ef71-4871-ad5a-771c98e1059a
Saw, S.M.
0684517e-f27e-49f0-98c3-7630e8fd1bbd
Pan, A.
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Lim, W.Y., Kwek, K., Chong, Y.S., Lee, Y.S., Yap, F., Chan, Y.H., Godfrey, K.M., Gluckman, P.D., Saw, S.M. and Pan, A. (2014) Maternal adiposity and blood pressure in pregnancy: varying relations by ethnicity and gestational diabetes. Journal of Hypertension, 32 (4), 857-864. (doi:10.1097/HJH.0000000000000096). (PMID:24390251)

Record type: Article

Abstract



Objective:

Greater maternal adiposity is a potentially modifiable risk factor for elevated blood pressure during pregnancy; however, the association has been little studied in Asian populations, and no study has evaluated potential differences in the adiposity-blood pressure relation between ethnic groups or interaction with gestational diabetes.

Methods:

We performed a cross-sectional evaluation of a Singapore mother-offspring cohort comprising 799 pregnant Chinese, Malay and Indian women. Data on body weight, height, skinfold thickness and glycaemia (oral glucose tolerance test) were collected during the 2nd trimester; peripheral SBP and DBP were measured using an oscillometric device and central pressures by noninvasive radial applanation tonometry. The associations between adiposity measures BMI and sum of skinfold thickness and blood pressure outcomes were examined by linear regression with adjustment for potential confounders.

Results:

Higher maternal BMI was associated with elevated peripheral and central pressures: the increases in pressure (mmHg) for each kg/m2 increase in BMI were 1.19 (95% confidence interval, 1.03–1.36) for peripheral SBP, 0.76 (0.63–0.89) for peripheral DBP, 1.02 (0.87–1.17) for central systolic pressure and 0.26 (0.16–0.37) for central pulse pressure. The associations were generally stronger in Chinese women (P-interaction?=?0.03 for central pulse pressure) and individuals with gestational diabetes (P-interaction?=?0.03 for DBP and P-interaction?=?0.046 for central systolic pressure). Similar patterns of results were found when using skinfold thickness as the measure of adiposity.

Conclusion:

Maternal adiposity is associated with higher peripheral and central blood pressures during pregnancy. Stronger associations in Chinese women and individuals with gestational diabetes warrant further investigation.

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More information

Published date: April 2014
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 365856
URI: http://eprints.soton.ac.uk/id/eprint/365856
ISSN: 0263-6352
PURE UUID: e5d84678-a8ae-4400-9f49-928484666a65
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 17 Jun 2014 10:53
Last modified: 07 Oct 2020 01:35

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Contributors

Author: W.Y. Lim
Author: K. Kwek
Author: Y.S. Chong
Author: Y.S. Lee
Author: F. Yap
Author: Y.H. Chan
Author: K.M. Godfrey ORCID iD
Author: P.D. Gluckman
Author: S.M. Saw
Author: A. Pan

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