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Dietary total antioxidant capacity is related to glucose tolerance in older people: The Hertfordshire Cohort Study

Dietary total antioxidant capacity is related to glucose tolerance in older people: The Hertfordshire Cohort Study
Dietary total antioxidant capacity is related to glucose tolerance in older people: The Hertfordshire Cohort Study
Background and aims

Dietary antioxidants may play a protective role in the aetiology of type 2 diabetes. However, observational studies that examine the relationship between the antioxidant capacity of the diet and glucose metabolism are limited, particularly in older people. We aimed to examine the relationships between dietary total antioxidant capacity (TAC) and markers of glucose metabolism among 1441 men and 1253 women aged 59–73 years who participated in the Hertfordshire Cohort Study, UK.

Methods and results

Diet was assessed by food frequency questionnaire. Dietary TAC was estimated using published databases of TAC measured by four different assays: oxygen radical absorbance capacity (ORAC), ferric-reducing ability of plasma (FRAP), total radical-trapping antioxidant parameter (TRAP) and trolox equivalent antioxidant capacity (TEAC). Fasting and 120-min plasma glucose and insulin concentrations were measured during a standard 75-g oral glucose tolerance test. In men, dietary TAC estimated by all four assays was inversely associated with fasting insulin concentration and homoeostasis model assessment of insulin resistance (HOMA-IR); with the exception of ORAC, dietary TAC was also inversely related to 120-min glucose concentration. There were no associations with fasting glucose or 120-min insulin concentrations. In women, with the exception of the association between ORAC and 120-min insulin concentration, dietary TAC estimated by all assays showed consistent inverse associations with fasting and 120-min glucose and insulin concentrations and HOMA-IR. These associations were more marked among women with BMI ?30 kg/m2.

Conclusion

These findings suggest dietary TAC may have important protective effects on glucose tolerance, especially in older obese women.
total antioxidant capacity, diet, glucose tolerance, epidemiology
1590-3729
301-308
Okubo, H.
312209e4-0d07-4722-b86c-2d7bd211377f
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Phillips, D.I.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Robinson, S.M.
ba591c98-4380-456a-be8a-c452f992b69b
Okubo, H.
312209e4-0d07-4722-b86c-2d7bd211377f
Syddall, H.E.
a0181a93-8fc3-4998-a996-7963f0128328
Phillips, D.I.
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Sayer, A.A.
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Robinson, S.M.
ba591c98-4380-456a-be8a-c452f992b69b

Okubo, H., Syddall, H.E., Phillips, D.I., Sayer, A.A., Dennison, E.M., Cooper, C. and Robinson, S.M. (2014) Dietary total antioxidant capacity is related to glucose tolerance in older people: The Hertfordshire Cohort Study. Nutrition, Metabolism and Cardiovascular Diseases, 24 (3), 301-308. (doi:10.1016/j.numecd.2013.08.001). (PMID:24370447)

Record type: Article

Abstract

Background and aims

Dietary antioxidants may play a protective role in the aetiology of type 2 diabetes. However, observational studies that examine the relationship between the antioxidant capacity of the diet and glucose metabolism are limited, particularly in older people. We aimed to examine the relationships between dietary total antioxidant capacity (TAC) and markers of glucose metabolism among 1441 men and 1253 women aged 59–73 years who participated in the Hertfordshire Cohort Study, UK.

Methods and results

Diet was assessed by food frequency questionnaire. Dietary TAC was estimated using published databases of TAC measured by four different assays: oxygen radical absorbance capacity (ORAC), ferric-reducing ability of plasma (FRAP), total radical-trapping antioxidant parameter (TRAP) and trolox equivalent antioxidant capacity (TEAC). Fasting and 120-min plasma glucose and insulin concentrations were measured during a standard 75-g oral glucose tolerance test. In men, dietary TAC estimated by all four assays was inversely associated with fasting insulin concentration and homoeostasis model assessment of insulin resistance (HOMA-IR); with the exception of ORAC, dietary TAC was also inversely related to 120-min glucose concentration. There were no associations with fasting glucose or 120-min insulin concentrations. In women, with the exception of the association between ORAC and 120-min insulin concentration, dietary TAC estimated by all assays showed consistent inverse associations with fasting and 120-min glucose and insulin concentrations and HOMA-IR. These associations were more marked among women with BMI ?30 kg/m2.

Conclusion

These findings suggest dietary TAC may have important protective effects on glucose tolerance, especially in older obese women.

Full text not available from this repository.

More information

e-pub ahead of print date: 24 October 2013
Published date: March 2014
Keywords: total antioxidant capacity, diet, glucose tolerance, epidemiology
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 365858
URI: http://eprints.soton.ac.uk/id/eprint/365858
ISSN: 1590-3729
PURE UUID: 4a19b32b-4969-4441-95c1-8e32c95ff00e
ORCID for H.E. Syddall: ORCID iD orcid.org/0000-0003-0171-0306
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for S.M. Robinson: ORCID iD orcid.org/0000-0003-1766-7269

Catalogue record

Date deposited: 17 Jun 2014 10:51
Last modified: 18 Feb 2021 16:50

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Contributors

Author: H. Okubo
Author: H.E. Syddall ORCID iD
Author: D.I. Phillips
Author: A.A. Sayer
Author: E.M. Dennison ORCID iD
Author: C. Cooper ORCID iD
Author: S.M. Robinson ORCID iD

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