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A meta-analysis of reference markers of bone turnover for prediction of fracture

A meta-analysis of reference markers of bone turnover for prediction of fracture
A meta-analysis of reference markers of bone turnover for prediction of fracture
The aim of this report was to summarize the clinical performance of two reference bone turnover markers (BTMs) in the prediction of fracture risk. We used an updated systematic review to examine the performance characteristics of serum procollagen type I N propeptide (s-PINP) and serum C-terminal cross-linking telopeptide of type I collagen (s-CTX) in fracture risk prediction in untreated individuals in prospective cohort studies. We excluded cross-sectional studies. Ten potentially eligible publications were identified and six included in the meta-analysis. There was a significant association between s-PINP and the risk of fracture. The hazard ratio per SD increase in s-PINP (gradient of risk [GR]) was 1.23 (95 % CI 1.09–1.39) for men and women combined unadjusted for bone mineral density. There was also a significant association between s-CTX and risk of fracture, GR = 1.18 (95 % CI 1.05–1.34) unadjusted for bone mineral density. For the outcome of hip fracture, the association between s-CTX and risk of fracture was slightly higher, 1.23 (95 % CI 1.04–1.47). Thus, there is a modest but significant association between BTMs and risk of future fractures
0171-967X
560-567
Johansson, H.
05aa5476-bcb9-4b97-905e-00f1dfd9d691
Oden, A.
c018cdda-62cd-44a0-be3a-227484a568bb
Kanis, J.A.
8da04a36-08a7-4310-b4b4-a6d432439587
McCloskey, E.V.
38518227-db8f-4a53-88a6-462f469151de
Morris, H.A.
43a0e3e8-d30f-479f-81dc-bd9e9166cca2
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Vasikaran, S.
3eba71cd-6b5a-4e05-a65e-42fcc2950507
Johansson, H.
05aa5476-bcb9-4b97-905e-00f1dfd9d691
Oden, A.
c018cdda-62cd-44a0-be3a-227484a568bb
Kanis, J.A.
8da04a36-08a7-4310-b4b4-a6d432439587
McCloskey, E.V.
38518227-db8f-4a53-88a6-462f469151de
Morris, H.A.
43a0e3e8-d30f-479f-81dc-bd9e9166cca2
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Vasikaran, S.
3eba71cd-6b5a-4e05-a65e-42fcc2950507

Johansson, H., Oden, A., Kanis, J.A., McCloskey, E.V., Morris, H.A., Cooper, C. and Vasikaran, S. (2014) A meta-analysis of reference markers of bone turnover for prediction of fracture. Calcified Tissue International, 94 (5), 560-567. (doi:10.1007/s00223-014-9842-y). (PMID:24590144)

Record type: Article

Abstract

The aim of this report was to summarize the clinical performance of two reference bone turnover markers (BTMs) in the prediction of fracture risk. We used an updated systematic review to examine the performance characteristics of serum procollagen type I N propeptide (s-PINP) and serum C-terminal cross-linking telopeptide of type I collagen (s-CTX) in fracture risk prediction in untreated individuals in prospective cohort studies. We excluded cross-sectional studies. Ten potentially eligible publications were identified and six included in the meta-analysis. There was a significant association between s-PINP and the risk of fracture. The hazard ratio per SD increase in s-PINP (gradient of risk [GR]) was 1.23 (95 % CI 1.09–1.39) for men and women combined unadjusted for bone mineral density. There was also a significant association between s-CTX and risk of fracture, GR = 1.18 (95 % CI 1.05–1.34) unadjusted for bone mineral density. For the outcome of hip fracture, the association between s-CTX and risk of fracture was slightly higher, 1.23 (95 % CI 1.04–1.47). Thus, there is a modest but significant association between BTMs and risk of future fractures

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Published date: May 2014
Organisations: Faculty of Medicine

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Local EPrints ID: 365980
URI: http://eprints.soton.ac.uk/id/eprint/365980
ISSN: 0171-967X
PURE UUID: a8a16ccb-b15c-4f17-9c86-649f40f7d9ae
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 23 Jun 2014 08:35
Last modified: 05 Nov 2019 01:59

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Contributors

Author: H. Johansson
Author: A. Oden
Author: J.A. Kanis
Author: E.V. McCloskey
Author: H.A. Morris
Author: C. Cooper ORCID iD
Author: S. Vasikaran

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