Bone and metal - an orthopaedic perspective on osseointegration of metals
Bone and metal - an orthopaedic perspective on osseointegration of metals
The area of implant osseointegration is of major importance, given the predicted significant rise in the number of orthopaedic procedures and an increasingly ageing population. Osseointegration is a complex process involving a number of distinct mechanisms affected by the implant bulk properties and surface characteristics. Our understanding and ability to modify these mechanisms through alterations in implant design is continuously expanding. The following review considers the main aspects of material and surface alterations in metal implants, and the extent of their subsequent influence on osseointegration. Clinically, osseointegration results in asymptomatic stable durable fixation of orthopaedic implants. The complexity of achieving this outcome through incorporation and balance of contributory factors is highlighted through a clinical case report.
orthopaedic metal implants, osseointegration, biocompatibility, material bulk characteristics, surface characteristics
1-15
Goriainov, Vitali
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Cook, Richard
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Latham, Jeremy
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Dunlop, Douglas
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Oreffo, Richard O.C.
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Goriainov, Vitali
dc456832-0a5a-4816-8fb7-de132f044a99
Cook, Richard
06f8322d-81be-4f82-9326-19e55541c78f
Latham, Jeremy
c6c195b3-c4c3-41fd-b38f-0ae20dd52fd0
Dunlop, Douglas
5f8d8b5c-e516-48b8-831f-c6e5529a52cc
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Goriainov, Vitali, Cook, Richard, Latham, Jeremy, Dunlop, Douglas and Oreffo, Richard O.C.
(2014)
Bone and metal - an orthopaedic perspective on osseointegration of metals.
Acta Biomaterialia, .
(doi:10.1016/j.actbio.2014.06.004).
(PMID:24932769)
Abstract
The area of implant osseointegration is of major importance, given the predicted significant rise in the number of orthopaedic procedures and an increasingly ageing population. Osseointegration is a complex process involving a number of distinct mechanisms affected by the implant bulk properties and surface characteristics. Our understanding and ability to modify these mechanisms through alterations in implant design is continuously expanding. The following review considers the main aspects of material and surface alterations in metal implants, and the extent of their subsequent influence on osseointegration. Clinically, osseointegration results in asymptomatic stable durable fixation of orthopaedic implants. The complexity of achieving this outcome through incorporation and balance of contributory factors is highlighted through a clinical case report.
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e-pub ahead of print date: 13 June 2014
Keywords:
orthopaedic metal implants, osseointegration, biocompatibility, material bulk characteristics, surface characteristics
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 366047
URI: http://eprints.soton.ac.uk/id/eprint/366047
ISSN: 1742-7061
PURE UUID: 36e03912-93c6-4ff2-a649-c61a07ed6631
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Date deposited: 24 Jun 2014 12:03
Last modified: 15 Mar 2024 03:34
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Author:
Vitali Goriainov
Author:
Jeremy Latham
Author:
Douglas Dunlop
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