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UK Renal Registry 16th annual report: chapter 4 demography of patients waitlisted for renal transplantation in the UK: national and centre-specific analyses

UK Renal Registry 16th annual report: chapter 4 demography of patients waitlisted for renal transplantation in the UK: national and centre-specific analyses
UK Renal Registry 16th annual report: chapter 4 demography of patients waitlisted for renal transplantation in the UK: national and centre-specific analyses
Introduction: for suitable patients, renal transplantation is considered the optimal modality of renal replacement therapy, with availability of donor organs limiting the number of transplants undertaken. The 2006 kidney allocation policy was developed to ensure equity of allocation to patients on the transplant waiting list, whilst still achieving a good donor/recipient match. This study aims to describe the characteristics of the kidney transplant waiting list and variations in median waiting times.

Methods: demographics and clinical characteristics of all patients listed for a kidney only transplant in the UK on 1st January 2011 were examined. Renal unit variations were explored. Patients listed between January 2006 and December 2009 were included in analysis of waiting times to transplant.

Results: at the beginning of 2011, there were 6,699 patients registered active for kidney only transplant in UK; a prevalence rate of 107 pmp. The median age of prevalent listed patients was 53 years, with 8% aged 70 or above. Of the patients listed, 84% had started renal replacement therapy (RRT), 59% were male, 28% were from ethnic minorities, 50% had blood group type O, 28% were defined as difficult to HLA match and 23% were highly sensitised (calculated HLA antibody reaction frequency 85%). Median waiting time to transplant was 38 months. Waiting time was shorter for White patients (36 months) compared to Asian or Black patients (46 months), and was doubled in highly sensitised compared to un-sensitised patients.

Conclusions: intercentre variation was observed in the rate of wait-listing and in the proportion of listed patients across different ethnic groups, age, blood groups and level of sensitisation. This may reflect differences in baseline population characteristics as well as individual centre practice patterns. Median waiting times differ significantly across blood groups, degree of sensitisation and ethnic group
1660-8151
81-98
Pruthi, R.
5047c9f8-b852-4d25-8014-392f58b54c99
Hilton, R.
0a134d5a-7168-47c4-aec5-f0cdfe4fb81f
Pankhurst, L.
d6d29132-57b8-4a75-ad4c-6bc0c6a96fb5
Mamode, N.
ef6a57c7-9491-45c6-b161-0a9973aabba6
Hudson, A.
3b532bda-f60b-41fe-b89c-1c87dae7f43a
Roderick, P.
dbb3cd11-4c51-4844-982b-0eb30ad5085a
Ravanan, R.
fb02cbf8-fd47-46b1-a732-93fe2a2cb1c8
Pruthi, R.
5047c9f8-b852-4d25-8014-392f58b54c99
Hilton, R.
0a134d5a-7168-47c4-aec5-f0cdfe4fb81f
Pankhurst, L.
d6d29132-57b8-4a75-ad4c-6bc0c6a96fb5
Mamode, N.
ef6a57c7-9491-45c6-b161-0a9973aabba6
Hudson, A.
3b532bda-f60b-41fe-b89c-1c87dae7f43a
Roderick, P.
dbb3cd11-4c51-4844-982b-0eb30ad5085a
Ravanan, R.
fb02cbf8-fd47-46b1-a732-93fe2a2cb1c8

Pruthi, R., Hilton, R., Pankhurst, L., Mamode, N., Hudson, A., Roderick, P. and Ravanan, R. (2014) UK Renal Registry 16th annual report: chapter 4 demography of patients waitlisted for renal transplantation in the UK: national and centre-specific analyses. Nephron Clinical Practice, 125 (1-4), 81-98. (doi:10.1159/000360023).

Record type: Article

Abstract

Introduction: for suitable patients, renal transplantation is considered the optimal modality of renal replacement therapy, with availability of donor organs limiting the number of transplants undertaken. The 2006 kidney allocation policy was developed to ensure equity of allocation to patients on the transplant waiting list, whilst still achieving a good donor/recipient match. This study aims to describe the characteristics of the kidney transplant waiting list and variations in median waiting times.

Methods: demographics and clinical characteristics of all patients listed for a kidney only transplant in the UK on 1st January 2011 were examined. Renal unit variations were explored. Patients listed between January 2006 and December 2009 were included in analysis of waiting times to transplant.

Results: at the beginning of 2011, there were 6,699 patients registered active for kidney only transplant in UK; a prevalence rate of 107 pmp. The median age of prevalent listed patients was 53 years, with 8% aged 70 or above. Of the patients listed, 84% had started renal replacement therapy (RRT), 59% were male, 28% were from ethnic minorities, 50% had blood group type O, 28% were defined as difficult to HLA match and 23% were highly sensitised (calculated HLA antibody reaction frequency 85%). Median waiting time to transplant was 38 months. Waiting time was shorter for White patients (36 months) compared to Asian or Black patients (46 months), and was doubled in highly sensitised compared to un-sensitised patients.

Conclusions: intercentre variation was observed in the rate of wait-listing and in the proportion of listed patients across different ethnic groups, age, blood groups and level of sensitisation. This may reflect differences in baseline population characteristics as well as individual centre practice patterns. Median waiting times differ significantly across blood groups, degree of sensitisation and ethnic group

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Published date: 2014
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 366050
URI: https://eprints.soton.ac.uk/id/eprint/366050
ISSN: 1660-8151
PURE UUID: 8ba69fd8-6a22-43b0-9031-30aba8e2d2fb
ORCID for P. Roderick: ORCID iD orcid.org/0000-0001-9475-6850

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Date deposited: 20 Jun 2014 10:34
Last modified: 22 Oct 2019 00:54

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