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Letter. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Letter. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
Letter. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function–related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function–related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10?8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ~110,347 individuals. We identify pleiotropic associations among these loci with kidney function–related traits and risk of CKD. These findings provide new insights into the genetics of kidney function
1061-4036
904-909
Okada, Y.
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Sim, X.
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Gu, D.
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Takahashi, A.
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Maeda, S.
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He, J.
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Cho, Y.S.
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Tai, E.S.
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Tanaka, T.
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Roderick, Paul
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Okada, Y.
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Sim, X.
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Go, M.J.
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Wu, J.Y.
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Gu, D.
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Takeuchi, F.
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Takahashi, A.
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Maeda, S.
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Tsunoda, T.
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Chen, P.
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Aung, T.
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Seielstad, M.
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Teo, Y.Y.
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Tsai, F.J.
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Mei, H.
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Rao, D.C.
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Hixson, J.E.
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Chen, S.
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Katsuya, T.
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Isono, M.
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Chambers, J.C.
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Zhang, W.
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Kooner, J.S.
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Albrecht, E.
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Yamamoto, K.
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Kubo, M.
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Nakamura, Y.
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Kamatani, N.
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Kato, N.
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He, J.
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Chen, Y.T.
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Cho, Y.S.
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Tai, E.S.
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Tanaka, T.
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Roderick, Paul
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Okada, Y., Sim, X., Go, M.J., Wu, J.Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S.C., Wong, T.Y., Liu, J., Young, T.L., Aung, T., Seielstad, M., Teo, Y.Y., Kim, Y.J., Lee, J.Y., Han, B.G., Kang, D., Chen, C.H., Tsai, F.J., Chang, L.C., Fann, S.J., Mei, H., Rao, D.C., Hixson, J.E., Chen, S., Katsuya, T., Isono, M., Ogihara, T., Chambers, J.C., Zhang, W., Kooner, J.S., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, Y.T., Cho, Y.S., Tai, E.S., Tanaka, T. and Roderick, Paul (2012) Letter. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics, 44 (8), 904-909. (doi:10.1038/ng.2352). (PMID:22797727)

Record type: Article

Abstract

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function–related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function–related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10?8). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ~110,347 individuals. We identify pleiotropic associations among these loci with kidney function–related traits and risk of CKD. These findings provide new insights into the genetics of kidney function

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More information

e-pub ahead of print date: 15 July 2012
Published date: 2012
Organisations: Primary Care & Population Sciences

Identifiers

Local EPrints ID: 366083
URI: http://eprints.soton.ac.uk/id/eprint/366083
ISSN: 1061-4036
PURE UUID: 813ca487-f998-4311-9c91-0fff2ea18afc
ORCID for Paul Roderick: ORCID iD orcid.org/0000-0001-9475-6850

Catalogue record

Date deposited: 20 Jun 2014 14:35
Last modified: 09 Nov 2021 02:49

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Contributors

Author: Y. Okada
Author: X. Sim
Author: M.J. Go
Author: J.Y. Wu
Author: D. Gu
Author: F. Takeuchi
Author: A. Takahashi
Author: S. Maeda
Author: T. Tsunoda
Author: P. Chen
Author: S.C. Lim
Author: T.Y. Wong
Author: J. Liu
Author: T.L. Young
Author: T. Aung
Author: M. Seielstad
Author: Y.Y. Teo
Author: Y.J. Kim
Author: J.Y. Lee
Author: B.G. Han
Author: D. Kang
Author: C.H. Chen
Author: F.J. Tsai
Author: L.C. Chang
Author: S.J. Fann
Author: H. Mei
Author: D.C. Rao
Author: J.E. Hixson
Author: S. Chen
Author: T. Katsuya
Author: M. Isono
Author: T. Ogihara
Author: J.C. Chambers
Author: W. Zhang
Author: J.S. Kooner
Author: E. Albrecht
Author: K. Yamamoto
Author: M. Kubo
Author: Y. Nakamura
Author: N. Kamatani
Author: N. Kato
Author: J. He
Author: Y.T. Chen
Author: Y.S. Cho
Author: E.S. Tai
Author: T. Tanaka
Author: Paul Roderick ORCID iD

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