A systematic review to establish health-related quality-of-life domains for intervention targets in cancer cachexia
A systematic review to establish health-related quality-of-life domains for intervention targets in cancer cachexia
Objectives
To develop a model of the impact of cancer cachexia on patients by identifying the relevant health-related quality-of-life (HRQOL) issues, and to use the model to identify opportunities for intervention.
Methods
Standard systematic review methods were followed to identify papers which included direct quotes from cancer patients with cachexia or problems with eating or weight loss. Following thematic synthesis methodology, the quotes were coded, and themes and metathemes were extracted. The metathemes were used to develop a model of the patient's experience of cachexia.
Results
18 relevant papers were identified which, in total, contained interviews with more than 250 patients. 226 patient quotes were extracted from the papers and 171 codes. 26 themes and 8 metathemes were formulated. The model developed from the metathemes demonstrated a direct link between eating and food problems and negative emotions and also a link mediated by the associated physical decline. These links provide opportunities for interventions.
Conclusions
There are a vast number of HRQOL issues associated with cancer cachexia as identified from patients’ own words. The model generated from these issues indicates that relationships, coping and knowledge of the condition are important components of new psychosocial interventions.
307-314
Wheelwright, S.J.
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Darlington, A.-S.
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Hopkinson, J.B.
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Fitzsimmons, D.
ad5cd3da-d85b-46d1-a31f-8d634486d739
White, A.
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Johnson, C.D.
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September 2016
Wheelwright, S.J.
2df90681-fb0a-4871-ae7d-75c88b35024b
Darlington, A.-S.
472fcfc9-160b-4344-8113-8dd8760ff962
Hopkinson, J.B.
94af3631-78f6-4057-baaf-e5832dfd9439
Fitzsimmons, D.
ad5cd3da-d85b-46d1-a31f-8d634486d739
White, A.
1bc91e01-fd81-4c14-aaff-dcb3c9a009d3
Johnson, C.D.
e50aa9cd-8c61-4fe3-a0b3-f51cc3a6c74a
Wheelwright, S.J., Darlington, A.-S., Hopkinson, J.B., Fitzsimmons, D., White, A. and Johnson, C.D.
(2016)
A systematic review to establish health-related quality-of-life domains for intervention targets in cancer cachexia.
BMJ Supportive & Palliative Care, 6, .
(doi:10.1136/bmjspcare-2014-000680).
(PMID:24943495)
Abstract
Objectives
To develop a model of the impact of cancer cachexia on patients by identifying the relevant health-related quality-of-life (HRQOL) issues, and to use the model to identify opportunities for intervention.
Methods
Standard systematic review methods were followed to identify papers which included direct quotes from cancer patients with cachexia or problems with eating or weight loss. Following thematic synthesis methodology, the quotes were coded, and themes and metathemes were extracted. The metathemes were used to develop a model of the patient's experience of cachexia.
Results
18 relevant papers were identified which, in total, contained interviews with more than 250 patients. 226 patient quotes were extracted from the papers and 171 codes. 26 themes and 8 metathemes were formulated. The model developed from the metathemes demonstrated a direct link between eating and food problems and negative emotions and also a link mediated by the associated physical decline. These links provide opportunities for interventions.
Conclusions
There are a vast number of HRQOL issues associated with cancer cachexia as identified from patients’ own words. The model generated from these issues indicates that relationships, coping and knowledge of the condition are important components of new psychosocial interventions.
Text
post print A systematic review to establish health-related quality of life domains for intervention targets in cancer cachexia.docx
- Accepted Manuscript
Available under License Other.
More information
Accepted/In Press date: 25 May 2014
e-pub ahead of print date: 18 June 2014
Published date: September 2016
Organisations:
Faculty of Health Sciences
Identifiers
Local EPrints ID: 366248
URI: http://eprints.soton.ac.uk/id/eprint/366248
ISSN: 2045-435X
PURE UUID: ed7a8675-6e98-4e85-9b27-64e95c390ce1
Catalogue record
Date deposited: 27 Jun 2014 13:44
Last modified: 14 Mar 2024 17:05
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Contributors
Author:
J.B. Hopkinson
Author:
D. Fitzsimmons
Author:
A. White
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