Mid-infrared Ta2O5 waveguides for evanescent sensing of stem cell differentiation
Mid-infrared Ta2O5 waveguides for evanescent sensing of stem cell differentiation
Stem cell differentiation is a fundamental biological process of particular interest for regenerative medicine. Differentiated cells have been characterised using mid-infrared FTIR microscopy but the use of spatially unresolved spectroscopy remains unexplored. Evanescent waveguide sensing may allow non-contact, label-free and real-time monitoring of differentiation. We report preliminary FTIR-ATR measurements which successfully distinguish between lysates of cells grown under different conditions and initial results on the fabrication of mid-infrared Ta2O5 waveguides. We also identify potential routes to a wholly self-contained analytical device.
Rowe, D.J.
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Evans, N.D.
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Murugan, G.S.
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Pearce, S.J.
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Wilkinson, J.S.
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Rowe, D.J.
a0e0fe82-5e29-42b8-b370-5236a722f015
Evans, N.D.
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Murugan, G.S.
a867686e-0535-46cc-ad85-c2342086b25b
Pearce, S.J.
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Wilkinson, J.S.
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Rowe, D.J., Evans, N.D., Murugan, G.S., Pearce, S.J. and Wilkinson, J.S.
(2014)
Mid-infrared Ta2O5 waveguides for evanescent sensing of stem cell differentiation.
17th European Conference on Integrated Optics, 19th MicroOptics Conference, , Nice, France.
24 - 27 Jun 2014.
2 pp
.
Record type:
Conference or Workshop Item
(Paper)
Abstract
Stem cell differentiation is a fundamental biological process of particular interest for regenerative medicine. Differentiated cells have been characterised using mid-infrared FTIR microscopy but the use of spatially unresolved spectroscopy remains unexplored. Evanescent waveguide sensing may allow non-contact, label-free and real-time monitoring of differentiation. We report preliminary FTIR-ATR measurements which successfully distinguish between lysates of cells grown under different conditions and initial results on the fabrication of mid-infrared Ta2O5 waveguides. We also identify potential routes to a wholly self-contained analytical device.
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e-pub ahead of print date: 2014
Venue - Dates:
17th European Conference on Integrated Optics, 19th MicroOptics Conference, , Nice, France, 2014-06-24 - 2014-06-27
Organisations:
Optoelectronics Research Centre, Human Development & Health
Identifiers
Local EPrints ID: 366302
URI: http://eprints.soton.ac.uk/id/eprint/366302
PURE UUID: ee7ce137-181b-4557-a76a-a03b1d363af8
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Date deposited: 23 Jul 2014 16:56
Last modified: 15 Mar 2024 03:44
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Contributors
Author:
S.J. Pearce
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