The University of Southampton
University of Southampton Institutional Repository

The effect of earlier puberty on cardiometabolic risk factors in Afro-Caribbean children

The effect of earlier puberty on cardiometabolic risk factors in Afro-Caribbean children
The effect of earlier puberty on cardiometabolic risk factors in Afro-Caribbean children
An earlier onset of puberty is associated with increased cardiometabolic risk. We investigated whether this relation was independent of faster childhood growth or current size in an Afro-Caribbean birth cohort (n=259). Anthropometry was measured at birth and then 6-monthly. Tanner staging started at age 8 years. Cardiometabolic risk factors were measured at mean age 11.5 years. In boys, pubarchal stage and testicular size were associated with lower high-density lipoprotein cholesterol, higher systolic blood pressure, and higher homeostasis model assessment of insulin resistance score, but not after adjusting for current body mass index (BMI) or rate of growth (up to age 8 years). In girls, earlier menarche and greater breast development were associated with higher fasting glucose even after adjusting for current BMI or prior growth. Pubarchal stage was associated with systolic blood pressure, even after adjusting for current BMI and prior growth. We concluded that earlier puberty is independently associated with cardiometabolic risk in girls but not in boys.
blood pressure, glucose, growth, insulin resistance, puberty
0334-018X
453-460
Boyne, M.S.
4f1a8543-68dd-4e6a-a75c-013faca58a91
Thame, M.
071c8725-1b66-4c64-b3fa-a13077570a4b
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Fraser, R.A.
dce75bf6-17fc-4502-a8fd-e8ce4e6d012a
Gabay, L.
770a4005-147e-4992-a6c5-abcb07e1a2aa
Taylor-Bryan, C.
819f0ed6-c3f5-4b0e-a35c-87b327a61a13
Forrester, T.E.
bb3a3675-9204-4743-b4e0-f8d0ddd55932
Boyne, M.S.
4f1a8543-68dd-4e6a-a75c-013faca58a91
Thame, M.
071c8725-1b66-4c64-b3fa-a13077570a4b
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Fraser, R.A.
dce75bf6-17fc-4502-a8fd-e8ce4e6d012a
Gabay, L.
770a4005-147e-4992-a6c5-abcb07e1a2aa
Taylor-Bryan, C.
819f0ed6-c3f5-4b0e-a35c-87b327a61a13
Forrester, T.E.
bb3a3675-9204-4743-b4e0-f8d0ddd55932

Boyne, M.S., Thame, M., Osmond, C., Fraser, R.A., Gabay, L., Taylor-Bryan, C. and Forrester, T.E. (2014) The effect of earlier puberty on cardiometabolic risk factors in Afro-Caribbean children. Journal of Pediatric Endocrinology and Metabolism, 27 (5-6), 453-460. (doi:10.1515/jpem-2013-0324). (PMID:24468602)

Record type: Article

Abstract

An earlier onset of puberty is associated with increased cardiometabolic risk. We investigated whether this relation was independent of faster childhood growth or current size in an Afro-Caribbean birth cohort (n=259). Anthropometry was measured at birth and then 6-monthly. Tanner staging started at age 8 years. Cardiometabolic risk factors were measured at mean age 11.5 years. In boys, pubarchal stage and testicular size were associated with lower high-density lipoprotein cholesterol, higher systolic blood pressure, and higher homeostasis model assessment of insulin resistance score, but not after adjusting for current body mass index (BMI) or rate of growth (up to age 8 years). In girls, earlier menarche and greater breast development were associated with higher fasting glucose even after adjusting for current BMI or prior growth. Pubarchal stage was associated with systolic blood pressure, even after adjusting for current BMI and prior growth. We concluded that earlier puberty is independently associated with cardiometabolic risk in girls but not in boys.

This record has no associated files available for download.

More information

e-pub ahead of print date: 27 January 2014
Published date: 1 May 2014
Keywords: blood pressure, glucose, growth, insulin resistance, puberty
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 366422
URI: http://eprints.soton.ac.uk/id/eprint/366422
ISSN: 0334-018X
PURE UUID: 4cf25a78-aace-4a5e-84a4-7cdd7a669531
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655

Catalogue record

Date deposited: 27 Jun 2014 11:06
Last modified: 15 Mar 2024 02:50

Export record

Altmetrics

Contributors

Author: M.S. Boyne
Author: M. Thame
Author: C. Osmond ORCID iD
Author: R.A. Fraser
Author: L. Gabay
Author: C. Taylor-Bryan
Author: T.E. Forrester

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×