Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium
Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel broadband ultrasound attenuation (BUA; n = 14 260), velocity of sound (VOS; n = 15 514) and BMD (n = 4566) in 13 discovery cohorts. Independent replication involved seven cohorts with GWA data (in silico n = 11 452) and new genotyping in 15 cohorts (de novo n = 24 902). In combined random effects, meta-analysis of the discovery and replication cohorts, nine single nucleotide polymorphisms (SNPs) had genome-wide significant (P < 5 × 10(-8)) associations with heel bone properties. Alongside SNPs within or near previously identified osteoporosis susceptibility genes including ESR1 (6q25.1: rs4869739, rs3020331, rs2982552), SPTBN1 (2p16.2: rs11898505), RSPO3 (6q22.33: rs7741021), WNT16 (7q31.31: rs2908007), DKK1 (10q21.1: rs7902708) and GPATCH1 (19q13.11: rs10416265), we identified a new locus on chromosome 11q14.2 (rs597319 close to TMEM135, a gene recently linked to osteoblastogenesis and longevity) significantly associated with both BUA and VOS (P < 8.23 × 10(-14)). In meta-analyses involving 25 cohorts with up to 14 985 fracture cases, six of 10 SNPs associated with heel bone properties at P < 5 × 10(-6) also had the expected direction of association with any fracture (P < 0.05), including three SNPs with P < 0.005: 6q22.33 (rs7741021), 7q31.31 (rs2908007) and 10q21.1 (rs7902708). In conclusion, this GWA study reveals the effect of several genes common to central DXA-derived BMD and heel ultrasound/DXA measures and points to a new genetic locus with potential implications for better understanding of osteoporosis pathophysiology.
3054-3068
Moayyeri, Alireza
009152af-0b2d-4d41-ad96-edaabd862080
Hsu, Yi-Hsiang
92a9e5c4-cfce-4f64-9535-ffd50a5fc2d9
Karasik, David
aa298c9a-b592-46d9-9ed8-cd4d6ffbb27e
Estrada, Karol
526d1128-97ca-46d3-a917-cada9b3ac383
Xiao, Su-Mei
c8195b2d-81af-432c-ac01-649d9cd9537d
Nielson, Carrie
5acc1e99-7e08-4558-aa48-8c39bfb11093
Srikanth, Priya
d97ff3f7-03a3-4bdf-b39a-20d6b235dc44
Giroux, Sylvie
c6d62c5b-97ed-4dd4-bb67-ff7293979581
Wilson, Scott G.
0cc83bb8-b711-4457-b493-d99a78b0cce0
Zheng, Hou-Feng
df932ae5-8163-4854-b7e8-68b90ff0dc8d
Smith, Albert V.
d93d702c-f6c9-4e06-be96-0c971c27e0df
Pye, Stephen R.
be84e0bc-7d71-4a27-86e0-d006acc089a1
Leo, Paul J.
cc727e9a-0b0e-4e1c-8a71-12fc5cf209e3
Teumer, Alexander
6314f011-234c-4406-95a0-ea46c276ba9b
Hwang, Joo-Yeon
4011277a-2e4e-4036-ada6-3f103ff35d5d
Ohlsson, Claes
98168752-6ef1-40c6-b873-9361cc99358b
McGuigan, Fiona
5d258647-1314-4154-9a4d-8818668d5501
Minster, Ryan L.
831636dd-0397-48f8-a521-1674608f73ee
Hayward, Caroline
8b58ae74-401a-4306-8b8f-c8414485131c
Olmos, José M.
90b04635-d81e-4c51-ae90-d25f39c0221c
Lyytikäinen, Leo-Pekka
c229176b-747e-49b5-a222-e76fe2eba322
Lewis, Joshua R.
9ea0ba64-4328-46d6-b23e-7e2b7e489e07
Swart, Karin M.A.
dd03f3e9-15bf-4d5e-91cf-f672eefd116c
Masi, Laura
2d9e3b53-7fa0-4de1-b5c6-e3b76949946f
Oldmeadow, Chris
01511359-3105-4f3c-b788-2bd357ebb7e1
Holliday, Elizabeth G.
5b3df1ad-69e9-4b63-9e3b-270198e9f296
Cheng, Sulin
66b87070-403d-45ee-a8ae-4bdbd9e9f70b
van Schoor, Natasja M.
3a59a196-b132-414f-81de-2ad3b21f7a74
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Kruk, Marcin
dcb0f29c-733f-4891-a21b-b02e430f85b7
del Greco M, Fabiola
38352fde-0125-48a8-b6ec-6672703e9216
Igl, Wilmar
a3722cdf-0a15-4b60-a069-407c5edb52be
Trummer, Olivia
0006b4e3-cbd1-4a0c-81cd-bb964fc26ed2
Grigoriou, Efi
7a58cc93-ce26-4f99-b8f9-7155f6f6f8ad
Luben, Robert
45fbac1d-ed4b-4a64-8f44-9b1afc94df6d
Liu, Ching-Ti
e25e7390-83ee-4a75-9199-1e5fa79e84ff
Zhou, Yanhua
09cf2f1d-e21c-4826-866f-0bfefc0b9e60
Oei, Ling
97f0fa3f-fd8c-421b-a962-e2600914b88c
Medina-Gomez, Carolina
f2383784-89c7-45ef-9904-3be3923c4446
Zmuda, Joseph
533c560a-6d29-4a4f-8df1-4f46ae1221f8
Tranah, Greg
896ff254-de6c-4c9a-a214-c8eee5d01028
Brown, Suzanne J.
3c409458-c5da-44d3-9202-912f5903acb6
Williams, Frances M
3eaed376-82ee-4d05-bf03-f13f8d3ba300
Soranzo, Nicole
959629a3-c46e-46c2-93b3-720e66e04fb0
Jakobsdottir, Johanna
c0a426a0-8d1d-4961-9187-b2658359617d
Siggeirsdottir, Kristin
bc469433-457c-420a-99c5-ef774c9ae4af
Holliday, Kate L.
58c01428-143a-4fc8-bd97-eb513573a697
Hannemann, Anke
27fa5104-257b-44ca-9016-7048c5ebdeb9
Go, Min Jin
b5fc8bdc-6408-44f2-8c45-f273f94aa74d
Garcia, Melissa
2a05f345-3500-4170-b36b-d4b6bd7a0afd
Polasek, Ozren
e5975087-c8c1-4938-9caf-c9212d41ff08
Laaksonen, Marika
803c9bc6-d0c6-423f-9930-08231b718e18
Zhu, Kun
499a27a4-dbe3-42b6-8f20-c4cf02ea4194
Enneman, Anke W.
5fb62746-da60-4e2b-9e89-ab1e0b8acbaa
McEvoy, Mark
60b10088-7ff6-496f-b832-1abe0bcc1ce9
Peel, Roseanne
f19e1a54-34a3-4e70-9edc-5d5237cdbc09
Sham, Pak Chung
80f7a308-4933-47ab-a1ce-95e2ea2fc7be
Jaworski, Maciej
3136e884-4dc9-456e-aea4-73230f6a5022
Johansson, Åsa
519c7b21-15b4-49a8-bdb3-4b9915943829
Hicks, Andrew A.
b94e286b-b1ec-4a88-b691-e0c30a3d4078
Pludowski, Pawel
534886b9-ba10-47c1-aacd-371027ad52ee
Scott, Rodney
ab036a39-b13e-47dc-94f9-af5263278ccd
Dhonukshe-Rutten, Rosalie A.M.
136a0535-b2e1-43ea-a4af-94658c7c75b0
van der Velde, Nathalie
54e7631d-a9a1-4752-a9a9-e6249f1322b3
Kähönen, Mika
1155e797-98f0-4204-96be-b8f410155340
Viikari, Jorma S.
68bb39bb-54e2-437f-9bee-48a6682de962
Sievänen, Harri
6a8c29f3-7840-4ee9-96e0-d868f990d055
Raitakari, Olli T.
6cf56ed9-a97a-45b6-8722-0aacc3e85f73
González-Macías, Jesús
ee14fc1c-6b07-436a-a0d6-27c079843924
Hernández, Jose L.
e24afeee-dbb7-410c-85a8-c1dcd2f8ab2d
Mellström, Dan
178bfc48-331d-4dec-bda0-45e72d303f6e
Ljunggren, Osten
c3230697-b7eb-4918-b484-38b06706efe9
Cho, Yoon Shin
69dbd167-c4d9-4bdf-b559-bd01b5df2eb4
Völker, Uwe
532f4bd7-8c8b-4a38-b245-14ff03dc2671
Nauck, Matthias
814bd383-cfa8-4374-8350-0fffb6683248
Homuth, Georg
932c3501-8ff1-4c53-b329-41e658a68e8b
Völzke, Henry
7a82b5da-95dd-4f33-9e7f-693e50ff19cb
Haring, Robin
4b1e1816-6965-4afa-89d1-c98a8ddeb00f
Brown, Matthew A.
2e7de455-bcc3-4b8b-a7b9-96b6e0367c1d
McCloskey, Eugene
3a2fac33-b400-4ae3-a212-04c3c3d2a517
Nicholson, Geoffrey C.
fe7ee115-799b-4238-89ea-e6ad97e44af3
Eastell, Richard
b19615e4-bc97-4ddf-b8d7-7f48b7220228
Eisman, John A.
5971006c-7da2-470c-8a6e-fff5755dd1a5
Jones, Graeme
f26c7d03-cd84-40c8-ae3a-286e861a5a29
Reid, Ian R.
be10ff32-2894-49c4-b7ab-934698aa3523
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Wark, John
21da66d5-dedb-4bc6-bb13-4011ab459e48
Boonen, Steven
fbfd999d-e425-406c-b66e-ca1b8150497b
Vanderschueren, Dirk
f705ade5-7105-4fd7-8d74-17e4f8b7f32c
Wu, Frederick C.W.
79aa87f8-45a7-48ad-99ee-ddc10fb73a22
Aspelund, Thor
86666aea-6141-4c5f-acad-6b0feda548f6
Richards, J.Brent
b04a12d6-4df8-472a-a662-d25441c8cfe9
Bauer, Doug
9e62732e-accd-4f67-8b3b-7d0ba3436870
Hofman, Albert
19e6a48f-bef9-43bd-8c54-1b6057ead0bc
Khaw, Kay-Tee
b17eadde-5721-45e8-8bf5-ac048db9fb44
Dedoussis, George
7560d640-805a-41c0-86fd-9219aa58b20a
Obermayer-Pietsch, Barbara
f366779e-4808-4bf5-bb8e-6523b96656b9
Gyllensten, Ulf
08b60a47-7dbc-4a1d-97e4-a28f91d092a7
Pramstaller, Peter P.
bfe5327d-a3df-44ef-b163-258132286079
Lorenc, Roman S.
f0a1113f-a960-4f71-8b15-4674fac30c50
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Kung, Annie Wai Chee
f452d5a2-35a4-49f2-b363-6bd1f5fb8542
Lips, Paul
b51616d3-024f-4d42-94d1-bf3911668ad6
Alen, Markku
553f8c3f-d10d-490f-b565-cbac62a7fa0f
Attia, John
680fd379-ec31-43cb-a27c-01bc085dc983
Brandi, Maria Luisa
b42820a8-1622-4a0d-8f9b-3f53f2e90180
de Groot, Lisette C.P.G.M.
38562932-0f86-46af-94aa-906bfc3cd4c1
Lehtimäki, Terho
c8c72e98-8043-42dc-99d2-7574ff4c3d6b
Riancho, José A.
4de3e67e-8e26-4528-b84c-c29a5cf00b40
Campbell, Harry
7ef78bec-0f39-477c-baa5-a773d59aa7c7
Liu, Yongmei
26d47909-5812-45a8-8014-8b94ce8ccb85
Harris, Tamara B.
fa722899-4b5e-45ee-9725-9523ecb633ad
Akesson, Kristina
a9c638a7-6bd4-4f56-a7e4-89e471061f83
Karlsson, Magnus
85188a16-227b-4a86-a4cc-7b222ca26c5c
Lee, Jong-Young
85a5c360-9729-4176-a928-856026a5e7e0
Wallaschofski, Henri
c93faf02-0c32-4673-abf5-f2dfe7ceb496
Duncan, Emma L.
881b5a19-428d-4a07-97c0-59492e814f56
O'Neill, Terence W.
d7396fa9-14be-42e9-80d9-4a857f77309e
Gudnason, Vilmundur
75cefe2e-c5f6-4d85-9a92-cd8c29dd6a94
Spector, Timothy D.
a60c3efb-6833-43f0-bfaa-f39466f1f0eb
Rousseau, François
e06d421b-d447-4d1b-ad63-a0d38ba0b3ec
Orwoll, Eric
65da4e11-2b2e-44fa-9a56-f60aac992f19
Cummings, Steven R.
7b3d4b1b-5ae4-40fd-b3e3-ee964e0703f0
Wareham, Nick J.
a1f361fa-e5e6-40c6-be7b-b4fb61bd0924
Rivadeneira, Fernando
8441b9d3-6d8e-4b33-8827-dd70d80db200
Uitterlinden, Andre G.
845d72ec-de5a-4d53-9678-7469af317b29
Prince, Richard L.
f4f86568-7756-4da3-80ea-745cc5e9c606
Kiel, Douglas P.
ff4d761f-9e48-415b-aae2-0c45381fd05f
Reeve, Jonathan
022c3cac-fb64-4b21-8205-a63803b7e63f
Kaptoge, Stephen K.
6dcecd22-dd25-4a8b-9dc2-54c781ff8394
1 June 2014
Moayyeri, Alireza
009152af-0b2d-4d41-ad96-edaabd862080
Hsu, Yi-Hsiang
92a9e5c4-cfce-4f64-9535-ffd50a5fc2d9
Karasik, David
aa298c9a-b592-46d9-9ed8-cd4d6ffbb27e
Estrada, Karol
526d1128-97ca-46d3-a917-cada9b3ac383
Xiao, Su-Mei
c8195b2d-81af-432c-ac01-649d9cd9537d
Nielson, Carrie
5acc1e99-7e08-4558-aa48-8c39bfb11093
Srikanth, Priya
d97ff3f7-03a3-4bdf-b39a-20d6b235dc44
Giroux, Sylvie
c6d62c5b-97ed-4dd4-bb67-ff7293979581
Wilson, Scott G.
0cc83bb8-b711-4457-b493-d99a78b0cce0
Zheng, Hou-Feng
df932ae5-8163-4854-b7e8-68b90ff0dc8d
Smith, Albert V.
d93d702c-f6c9-4e06-be96-0c971c27e0df
Pye, Stephen R.
be84e0bc-7d71-4a27-86e0-d006acc089a1
Leo, Paul J.
cc727e9a-0b0e-4e1c-8a71-12fc5cf209e3
Teumer, Alexander
6314f011-234c-4406-95a0-ea46c276ba9b
Hwang, Joo-Yeon
4011277a-2e4e-4036-ada6-3f103ff35d5d
Ohlsson, Claes
98168752-6ef1-40c6-b873-9361cc99358b
McGuigan, Fiona
5d258647-1314-4154-9a4d-8818668d5501
Minster, Ryan L.
831636dd-0397-48f8-a521-1674608f73ee
Hayward, Caroline
8b58ae74-401a-4306-8b8f-c8414485131c
Olmos, José M.
90b04635-d81e-4c51-ae90-d25f39c0221c
Lyytikäinen, Leo-Pekka
c229176b-747e-49b5-a222-e76fe2eba322
Lewis, Joshua R.
9ea0ba64-4328-46d6-b23e-7e2b7e489e07
Swart, Karin M.A.
dd03f3e9-15bf-4d5e-91cf-f672eefd116c
Masi, Laura
2d9e3b53-7fa0-4de1-b5c6-e3b76949946f
Oldmeadow, Chris
01511359-3105-4f3c-b788-2bd357ebb7e1
Holliday, Elizabeth G.
5b3df1ad-69e9-4b63-9e3b-270198e9f296
Cheng, Sulin
66b87070-403d-45ee-a8ae-4bdbd9e9f70b
van Schoor, Natasja M.
3a59a196-b132-414f-81de-2ad3b21f7a74
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Kruk, Marcin
dcb0f29c-733f-4891-a21b-b02e430f85b7
del Greco M, Fabiola
38352fde-0125-48a8-b6ec-6672703e9216
Igl, Wilmar
a3722cdf-0a15-4b60-a069-407c5edb52be
Trummer, Olivia
0006b4e3-cbd1-4a0c-81cd-bb964fc26ed2
Grigoriou, Efi
7a58cc93-ce26-4f99-b8f9-7155f6f6f8ad
Luben, Robert
45fbac1d-ed4b-4a64-8f44-9b1afc94df6d
Liu, Ching-Ti
e25e7390-83ee-4a75-9199-1e5fa79e84ff
Zhou, Yanhua
09cf2f1d-e21c-4826-866f-0bfefc0b9e60
Oei, Ling
97f0fa3f-fd8c-421b-a962-e2600914b88c
Medina-Gomez, Carolina
f2383784-89c7-45ef-9904-3be3923c4446
Zmuda, Joseph
533c560a-6d29-4a4f-8df1-4f46ae1221f8
Tranah, Greg
896ff254-de6c-4c9a-a214-c8eee5d01028
Brown, Suzanne J.
3c409458-c5da-44d3-9202-912f5903acb6
Williams, Frances M
3eaed376-82ee-4d05-bf03-f13f8d3ba300
Soranzo, Nicole
959629a3-c46e-46c2-93b3-720e66e04fb0
Jakobsdottir, Johanna
c0a426a0-8d1d-4961-9187-b2658359617d
Siggeirsdottir, Kristin
bc469433-457c-420a-99c5-ef774c9ae4af
Holliday, Kate L.
58c01428-143a-4fc8-bd97-eb513573a697
Hannemann, Anke
27fa5104-257b-44ca-9016-7048c5ebdeb9
Go, Min Jin
b5fc8bdc-6408-44f2-8c45-f273f94aa74d
Garcia, Melissa
2a05f345-3500-4170-b36b-d4b6bd7a0afd
Polasek, Ozren
e5975087-c8c1-4938-9caf-c9212d41ff08
Laaksonen, Marika
803c9bc6-d0c6-423f-9930-08231b718e18
Zhu, Kun
499a27a4-dbe3-42b6-8f20-c4cf02ea4194
Enneman, Anke W.
5fb62746-da60-4e2b-9e89-ab1e0b8acbaa
McEvoy, Mark
60b10088-7ff6-496f-b832-1abe0bcc1ce9
Peel, Roseanne
f19e1a54-34a3-4e70-9edc-5d5237cdbc09
Sham, Pak Chung
80f7a308-4933-47ab-a1ce-95e2ea2fc7be
Jaworski, Maciej
3136e884-4dc9-456e-aea4-73230f6a5022
Johansson, Åsa
519c7b21-15b4-49a8-bdb3-4b9915943829
Hicks, Andrew A.
b94e286b-b1ec-4a88-b691-e0c30a3d4078
Pludowski, Pawel
534886b9-ba10-47c1-aacd-371027ad52ee
Scott, Rodney
ab036a39-b13e-47dc-94f9-af5263278ccd
Dhonukshe-Rutten, Rosalie A.M.
136a0535-b2e1-43ea-a4af-94658c7c75b0
van der Velde, Nathalie
54e7631d-a9a1-4752-a9a9-e6249f1322b3
Kähönen, Mika
1155e797-98f0-4204-96be-b8f410155340
Viikari, Jorma S.
68bb39bb-54e2-437f-9bee-48a6682de962
Sievänen, Harri
6a8c29f3-7840-4ee9-96e0-d868f990d055
Raitakari, Olli T.
6cf56ed9-a97a-45b6-8722-0aacc3e85f73
González-Macías, Jesús
ee14fc1c-6b07-436a-a0d6-27c079843924
Hernández, Jose L.
e24afeee-dbb7-410c-85a8-c1dcd2f8ab2d
Mellström, Dan
178bfc48-331d-4dec-bda0-45e72d303f6e
Ljunggren, Osten
c3230697-b7eb-4918-b484-38b06706efe9
Cho, Yoon Shin
69dbd167-c4d9-4bdf-b559-bd01b5df2eb4
Völker, Uwe
532f4bd7-8c8b-4a38-b245-14ff03dc2671
Nauck, Matthias
814bd383-cfa8-4374-8350-0fffb6683248
Homuth, Georg
932c3501-8ff1-4c53-b329-41e658a68e8b
Völzke, Henry
7a82b5da-95dd-4f33-9e7f-693e50ff19cb
Haring, Robin
4b1e1816-6965-4afa-89d1-c98a8ddeb00f
Brown, Matthew A.
2e7de455-bcc3-4b8b-a7b9-96b6e0367c1d
McCloskey, Eugene
3a2fac33-b400-4ae3-a212-04c3c3d2a517
Nicholson, Geoffrey C.
fe7ee115-799b-4238-89ea-e6ad97e44af3
Eastell, Richard
b19615e4-bc97-4ddf-b8d7-7f48b7220228
Eisman, John A.
5971006c-7da2-470c-8a6e-fff5755dd1a5
Jones, Graeme
f26c7d03-cd84-40c8-ae3a-286e861a5a29
Reid, Ian R.
be10ff32-2894-49c4-b7ab-934698aa3523
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Wark, John
21da66d5-dedb-4bc6-bb13-4011ab459e48
Boonen, Steven
fbfd999d-e425-406c-b66e-ca1b8150497b
Vanderschueren, Dirk
f705ade5-7105-4fd7-8d74-17e4f8b7f32c
Wu, Frederick C.W.
79aa87f8-45a7-48ad-99ee-ddc10fb73a22
Aspelund, Thor
86666aea-6141-4c5f-acad-6b0feda548f6
Richards, J.Brent
b04a12d6-4df8-472a-a662-d25441c8cfe9
Bauer, Doug
9e62732e-accd-4f67-8b3b-7d0ba3436870
Hofman, Albert
19e6a48f-bef9-43bd-8c54-1b6057ead0bc
Khaw, Kay-Tee
b17eadde-5721-45e8-8bf5-ac048db9fb44
Dedoussis, George
7560d640-805a-41c0-86fd-9219aa58b20a
Obermayer-Pietsch, Barbara
f366779e-4808-4bf5-bb8e-6523b96656b9
Gyllensten, Ulf
08b60a47-7dbc-4a1d-97e4-a28f91d092a7
Pramstaller, Peter P.
bfe5327d-a3df-44ef-b163-258132286079
Lorenc, Roman S.
f0a1113f-a960-4f71-8b15-4674fac30c50
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Kung, Annie Wai Chee
f452d5a2-35a4-49f2-b363-6bd1f5fb8542
Lips, Paul
b51616d3-024f-4d42-94d1-bf3911668ad6
Alen, Markku
553f8c3f-d10d-490f-b565-cbac62a7fa0f
Attia, John
680fd379-ec31-43cb-a27c-01bc085dc983
Brandi, Maria Luisa
b42820a8-1622-4a0d-8f9b-3f53f2e90180
de Groot, Lisette C.P.G.M.
38562932-0f86-46af-94aa-906bfc3cd4c1
Lehtimäki, Terho
c8c72e98-8043-42dc-99d2-7574ff4c3d6b
Riancho, José A.
4de3e67e-8e26-4528-b84c-c29a5cf00b40
Campbell, Harry
7ef78bec-0f39-477c-baa5-a773d59aa7c7
Liu, Yongmei
26d47909-5812-45a8-8014-8b94ce8ccb85
Harris, Tamara B.
fa722899-4b5e-45ee-9725-9523ecb633ad
Akesson, Kristina
a9c638a7-6bd4-4f56-a7e4-89e471061f83
Karlsson, Magnus
85188a16-227b-4a86-a4cc-7b222ca26c5c
Lee, Jong-Young
85a5c360-9729-4176-a928-856026a5e7e0
Wallaschofski, Henri
c93faf02-0c32-4673-abf5-f2dfe7ceb496
Duncan, Emma L.
881b5a19-428d-4a07-97c0-59492e814f56
O'Neill, Terence W.
d7396fa9-14be-42e9-80d9-4a857f77309e
Gudnason, Vilmundur
75cefe2e-c5f6-4d85-9a92-cd8c29dd6a94
Spector, Timothy D.
a60c3efb-6833-43f0-bfaa-f39466f1f0eb
Rousseau, François
e06d421b-d447-4d1b-ad63-a0d38ba0b3ec
Orwoll, Eric
65da4e11-2b2e-44fa-9a56-f60aac992f19
Cummings, Steven R.
7b3d4b1b-5ae4-40fd-b3e3-ee964e0703f0
Wareham, Nick J.
a1f361fa-e5e6-40c6-be7b-b4fb61bd0924
Rivadeneira, Fernando
8441b9d3-6d8e-4b33-8827-dd70d80db200
Uitterlinden, Andre G.
845d72ec-de5a-4d53-9678-7469af317b29
Prince, Richard L.
f4f86568-7756-4da3-80ea-745cc5e9c606
Kiel, Douglas P.
ff4d761f-9e48-415b-aae2-0c45381fd05f
Reeve, Jonathan
022c3cac-fb64-4b21-8205-a63803b7e63f
Kaptoge, Stephen K.
6dcecd22-dd25-4a8b-9dc2-54c781ff8394
