Salivary cortisol and cold pain sensitivity in female twins
Salivary cortisol and cold pain sensitivity in female twins
Background
There is a dearth of knowledge about the link between cortisol and pain sensitivity.
Purpose
We examined the association of salivary cortisol with indices of cold pain sensitivity in 198 female twins and explored the role of familial confounding.
Methods
Three-day saliva samples were collected for cortisol levels and a cold pressor test was used to collect pain ratings and time to threshold and tolerance. Linear regression modeling with generalized estimating equations examined the overall and within-pair associations.
Results
Lower diurnal variation of cortisol was associated with higher pain ratings at threshold (p?=?0.02) and tolerance (p?<?0.01). The relationship of diurnal variation with pain ratings at threshold and tolerance was minimally influenced by familial factors (i.e., genetics and common environment).
Conclusions
Understanding the genetic and non-genetic mechanisms underlying the link between HPA axis dysregulation and pain sensitivity may help to prevent chronic pain development and maintenance.
180-188
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Strachan, E.
44a68827-2092-4c79-8b8f-2d1190da2ddd
Dansie, E.
79e502e0-7302-44fe-836c-8f49ad69ffb3
Crofford, L.J.
d7f71ea6-4644-4069-8a12-9f41b1287b6e
Buchwald, D.
e8731f12-3ce1-4ef6-ad59-4219e1dc00de
Goldberg, J.
b2b230f7-07f9-426b-a498-2ddaad391dcf
Poeschia, B.
a43303f6-ea8e-493b-b969-a21f799d522f
Succop, A.
9a3b86c1-7b0f-4d0a-93cb-65a02ee223ea
Noonan, C.
d0b021cc-aec8-4d52-9436-02b77f26a666
Afari, N.
820bf485-22bb-4160-91f6-2b7e4837921d
1 April 2014
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Strachan, E.
44a68827-2092-4c79-8b8f-2d1190da2ddd
Dansie, E.
79e502e0-7302-44fe-836c-8f49ad69ffb3
Crofford, L.J.
d7f71ea6-4644-4069-8a12-9f41b1287b6e
Buchwald, D.
e8731f12-3ce1-4ef6-ad59-4219e1dc00de
Goldberg, J.
b2b230f7-07f9-426b-a498-2ddaad391dcf
Poeschia, B.
a43303f6-ea8e-493b-b969-a21f799d522f
Succop, A.
9a3b86c1-7b0f-4d0a-93cb-65a02ee223ea
Noonan, C.
d0b021cc-aec8-4d52-9436-02b77f26a666
Afari, N.
820bf485-22bb-4160-91f6-2b7e4837921d
Godfrey, K.M., Strachan, E., Dansie, E., Crofford, L.J., Buchwald, D., Goldberg, J., Poeschia, B., Succop, A., Noonan, C. and Afari, N.
(2014)
Salivary cortisol and cold pain sensitivity in female twins.
Annals of Behavioral Medicine, 47 (2), .
(doi:10.1007/s12160-013-9532-4).
(PMID:23955075)
Abstract
Background
There is a dearth of knowledge about the link between cortisol and pain sensitivity.
Purpose
We examined the association of salivary cortisol with indices of cold pain sensitivity in 198 female twins and explored the role of familial confounding.
Methods
Three-day saliva samples were collected for cortisol levels and a cold pressor test was used to collect pain ratings and time to threshold and tolerance. Linear regression modeling with generalized estimating equations examined the overall and within-pair associations.
Results
Lower diurnal variation of cortisol was associated with higher pain ratings at threshold (p?=?0.02) and tolerance (p?<?0.01). The relationship of diurnal variation with pain ratings at threshold and tolerance was minimally influenced by familial factors (i.e., genetics and common environment).
Conclusions
Understanding the genetic and non-genetic mechanisms underlying the link between HPA axis dysregulation and pain sensitivity may help to prevent chronic pain development and maintenance.
This record has no associated files available for download.
More information
Published date: 1 April 2014
Organisations:
Faculty of Medicine
Identifiers
Local EPrints ID: 366498
URI: http://eprints.soton.ac.uk/id/eprint/366498
ISSN: 0883-6612
PURE UUID: c02324fb-b4a5-454f-a3a2-9828288a2fba
Catalogue record
Date deposited: 01 Jul 2014 13:42
Last modified: 15 Mar 2024 02:43
Export record
Altmetrics
Contributors
Author:
E. Strachan
Author:
E. Dansie
Author:
L.J. Crofford
Author:
D. Buchwald
Author:
J. Goldberg
Author:
B. Poeschia
Author:
A. Succop
Author:
C. Noonan
Author:
N. Afari
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics