The University of Southampton
University of Southampton Institutional Repository

Salivary cortisol and cold pain sensitivity in female twins

Salivary cortisol and cold pain sensitivity in female twins
Salivary cortisol and cold pain sensitivity in female twins
Background

There is a dearth of knowledge about the link between cortisol and pain sensitivity.

Purpose

We examined the association of salivary cortisol with indices of cold pain sensitivity in 198 female twins and explored the role of familial confounding.

Methods

Three-day saliva samples were collected for cortisol levels and a cold pressor test was used to collect pain ratings and time to threshold and tolerance. Linear regression modeling with generalized estimating equations examined the overall and within-pair associations.

Results

Lower diurnal variation of cortisol was associated with higher pain ratings at threshold (p?=?0.02) and tolerance (p?<?0.01). The relationship of diurnal variation with pain ratings at threshold and tolerance was minimally influenced by familial factors (i.e., genetics and common environment).

Conclusions

Understanding the genetic and non-genetic mechanisms underlying the link between HPA axis dysregulation and pain sensitivity may help to prevent chronic pain development and maintenance.
0883-6612
180-188
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Strachan, E.
44a68827-2092-4c79-8b8f-2d1190da2ddd
Dansie, E.
79e502e0-7302-44fe-836c-8f49ad69ffb3
Crofford, L.J.
d7f71ea6-4644-4069-8a12-9f41b1287b6e
Buchwald, D.
e8731f12-3ce1-4ef6-ad59-4219e1dc00de
Goldberg, J.
b2b230f7-07f9-426b-a498-2ddaad391dcf
Poeschia, B.
a43303f6-ea8e-493b-b969-a21f799d522f
Succop, A.
9a3b86c1-7b0f-4d0a-93cb-65a02ee223ea
Noonan, C.
d0b021cc-aec8-4d52-9436-02b77f26a666
Afari, N.
820bf485-22bb-4160-91f6-2b7e4837921d
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Strachan, E.
44a68827-2092-4c79-8b8f-2d1190da2ddd
Dansie, E.
79e502e0-7302-44fe-836c-8f49ad69ffb3
Crofford, L.J.
d7f71ea6-4644-4069-8a12-9f41b1287b6e
Buchwald, D.
e8731f12-3ce1-4ef6-ad59-4219e1dc00de
Goldberg, J.
b2b230f7-07f9-426b-a498-2ddaad391dcf
Poeschia, B.
a43303f6-ea8e-493b-b969-a21f799d522f
Succop, A.
9a3b86c1-7b0f-4d0a-93cb-65a02ee223ea
Noonan, C.
d0b021cc-aec8-4d52-9436-02b77f26a666
Afari, N.
820bf485-22bb-4160-91f6-2b7e4837921d

Godfrey, K.M., Strachan, E., Dansie, E., Crofford, L.J., Buchwald, D., Goldberg, J., Poeschia, B., Succop, A., Noonan, C. and Afari, N. (2014) Salivary cortisol and cold pain sensitivity in female twins. Annals of Behavioral Medicine, 47 (2), 180-188. (doi:10.1007/s12160-013-9532-4). (PMID:23955075)

Record type: Article

Abstract

Background

There is a dearth of knowledge about the link between cortisol and pain sensitivity.

Purpose

We examined the association of salivary cortisol with indices of cold pain sensitivity in 198 female twins and explored the role of familial confounding.

Methods

Three-day saliva samples were collected for cortisol levels and a cold pressor test was used to collect pain ratings and time to threshold and tolerance. Linear regression modeling with generalized estimating equations examined the overall and within-pair associations.

Results

Lower diurnal variation of cortisol was associated with higher pain ratings at threshold (p?=?0.02) and tolerance (p?<?0.01). The relationship of diurnal variation with pain ratings at threshold and tolerance was minimally influenced by familial factors (i.e., genetics and common environment).

Conclusions

Understanding the genetic and non-genetic mechanisms underlying the link between HPA axis dysregulation and pain sensitivity may help to prevent chronic pain development and maintenance.

Full text not available from this repository.

More information

Published date: 1 April 2014
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 366498
URI: http://eprints.soton.ac.uk/id/eprint/366498
ISSN: 0883-6612
PURE UUID: c02324fb-b4a5-454f-a3a2-9828288a2fba
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 01 Jul 2014 13:42
Last modified: 07 Oct 2020 01:35

Export record

Altmetrics

Contributors

Author: K.M. Godfrey ORCID iD
Author: E. Strachan
Author: E. Dansie
Author: L.J. Crofford
Author: D. Buchwald
Author: J. Goldberg
Author: B. Poeschia
Author: A. Succop
Author: C. Noonan
Author: N. Afari

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×