Concise review: bridging the gap: bone regeneration using skeletal stem cell-based strategies - Where are we now?
Concise review: bridging the gap: bone regeneration using skeletal stem cell-based strategies - Where are we now?
Skeletal stem cells confer to bone its innate capacity for regeneration and repair. Bone regeneration strategies seek to harness and enhance this regenerative capacity for the replacement of tissue damaged or lost through congenital defects, trauma, functional/esthetic problems, and a broad range of diseases associated with an increasingly aged population. This review describes the state of the field and current steps to translate and apply skeletal stem cell biology in the clinic and the problems therein. Challenges are described along with key strategies including the isolation and ex vivo expansion of multipotential populations, the targeting/delivery of regenerative populations to sites of repair, and their differentiation toward bone lineages. Finally, preclinical models of bone repair are discussed along with their implications for clinical translation and the opportunities to harness that knowledge for musculoskeletal regeneration.
skeletal stem cell, mesenchymal, osteogenesis, translational research, angiogenesis, tissue regeneration, osteoprogenitor, bone tissue engineering
35-44
Dawson, Jonathan I.
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Kanczler, Janos
eb8db9ff-a038-475f-9030-48eef2b0559c
Tare, Rahul
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Kassem, Moustapha
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Oreffo, Richard O.C.
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January 2014
Dawson, Jonathan I.
b220fe76-498d-47be-9995-92da6c289cf3
Kanczler, Janos
eb8db9ff-a038-475f-9030-48eef2b0559c
Tare, Rahul
587c9db4-e409-4e7c-a02a-677547ab724a
Kassem, Moustapha
d67134a1-cb10-44f5-8d8d-3fbc2a580dff
Oreffo, Richard O.C.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Dawson, Jonathan I., Kanczler, Janos, Tare, Rahul, Kassem, Moustapha and Oreffo, Richard O.C.
(2014)
Concise review: bridging the gap: bone regeneration using skeletal stem cell-based strategies - Where are we now?
Stem Cells, 32 (1), .
(doi:10.1002/stem.1559).
(PMID:24115290)
Abstract
Skeletal stem cells confer to bone its innate capacity for regeneration and repair. Bone regeneration strategies seek to harness and enhance this regenerative capacity for the replacement of tissue damaged or lost through congenital defects, trauma, functional/esthetic problems, and a broad range of diseases associated with an increasingly aged population. This review describes the state of the field and current steps to translate and apply skeletal stem cell biology in the clinic and the problems therein. Challenges are described along with key strategies including the isolation and ex vivo expansion of multipotential populations, the targeting/delivery of regenerative populations to sites of repair, and their differentiation toward bone lineages. Finally, preclinical models of bone repair are discussed along with their implications for clinical translation and the opportunities to harness that knowledge for musculoskeletal regeneration.
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Accepted/In Press date: 12 August 2013
e-pub ahead of print date: 1 October 2013
Published date: January 2014
Keywords:
skeletal stem cell, mesenchymal, osteogenesis, translational research, angiogenesis, tissue regeneration, osteoprogenitor, bone tissue engineering
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 367173
URI: http://eprints.soton.ac.uk/id/eprint/367173
ISSN: 1066-5099
PURE UUID: 3412ef94-4460-4e5d-9eb3-2b8695ace356
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Date deposited: 24 Jul 2014 11:58
Last modified: 15 Mar 2024 03:31
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Author:
Janos Kanczler
Author:
Moustapha Kassem
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