The University of Southampton
University of Southampton Institutional Repository

PPO.17 Is congenital heart disease on the increase in the UK? A register-based study

PPO.17 Is congenital heart disease on the increase in the UK? A register-based study
PPO.17 Is congenital heart disease on the increase in the UK? A register-based study
Aim The aim of this study was to describe trends in the prevalence of congenital heart disease (CHD) according to severity and adjusted for maternal age.

Methods All CHD cases notified to six British Isles Network of Congenital Anomaly Registers between 1991–2010 formed this population-based study. Prevalence and 95% confidence intervals (CIs) were calculated as the number of cases (occurring in live births, fetal deaths or terminations for fetal anomaly) per 10,000 live and stillbirths. Relative risks (RRs) of CHD over time, adjusted for maternal age were estimated using multilevel Poisson models.

Results There were 19,353 singleton cases of CHD among 3,040,952 total births. Excluding, 2,848 (14.7%) cases with a chromosomal anomaly, 683 (3.6%) with a genetic syndrome and 2,639 (15.8%) with extra-cardiac anomalies, there were 13,183 isolated cases. Of these, 7,150 (54.2%, Prevalence = 23.51; 95% CI: 22.97–24.06 per 10,000 total births) were classed as mild, 3,204 (24.3%, Prevalence = 10.54; 95% CI: 10.18–10.91) as moderate and 1,143 (8.7%, Prevalence = 3.76 95%; CI: 3.54–3.98) as severe CHD. There were no significant trends in prevalence over time in mild (RR = 1.04; 95% CI:. 99–1.10; p = 0.096), moderate (RR = 0.99; 95% CI: 0.99–1.00; p = 0.168) or severe CHD (RR = 1.01; 95% CI: 1.00–1.02; p = 0.074), even after adjustment for maternal age. The risk of a pregnancy associated with a mild CHD was significantly greater in women aged 35 and over compared to aged 20–29 (RR = 1.16; 95% CI:1.04–1.29; p = 0.009).

Conclusion There were no significant differences in trends in the prevalence by CHD severity, before or after adjustment for maternal age.
1359-2998
A155-A155
Best, K.
bdccbebe-c81d-475f-883f-69bf524fd2bb
Draper, E.
a831db8d-6baa-4da9-82e3-faea89c53e85
Kurinczuk, J.
18e20c3d-59af-4e3b-9484-fa14341f4e8d
Stoianova, S.
94944d0f-9500-4036-8a77-bfaf2c3b42c1
Tucker, D.
5365973c-3503-4bfc-9436-75f571c8c06b
Wellesley, D.
17cbd6c1-0efb-4df1-ae05-64a44987c9c0
Rankin, J.
f46fdd1f-6006-4a21-ace2-b4d8d8c85c20
Best, K.
bdccbebe-c81d-475f-883f-69bf524fd2bb
Draper, E.
a831db8d-6baa-4da9-82e3-faea89c53e85
Kurinczuk, J.
18e20c3d-59af-4e3b-9484-fa14341f4e8d
Stoianova, S.
94944d0f-9500-4036-8a77-bfaf2c3b42c1
Tucker, D.
5365973c-3503-4bfc-9436-75f571c8c06b
Wellesley, D.
17cbd6c1-0efb-4df1-ae05-64a44987c9c0
Rankin, J.
f46fdd1f-6006-4a21-ace2-b4d8d8c85c20

Best, K., Draper, E., Kurinczuk, J., Stoianova, S., Tucker, D., Wellesley, D. and Rankin, J. (2014) PPO.17 Is congenital heart disease on the increase in the UK? A register-based study. Archives of Disease in Childhood - Fetal and Neonatal Edition, 99 (Suppl 1), A155-A155. (doi:10.1136/archdischild-2014-306576.457). (PMID:25021105)

Record type: Article

Abstract

Aim The aim of this study was to describe trends in the prevalence of congenital heart disease (CHD) according to severity and adjusted for maternal age.

Methods All CHD cases notified to six British Isles Network of Congenital Anomaly Registers between 1991–2010 formed this population-based study. Prevalence and 95% confidence intervals (CIs) were calculated as the number of cases (occurring in live births, fetal deaths or terminations for fetal anomaly) per 10,000 live and stillbirths. Relative risks (RRs) of CHD over time, adjusted for maternal age were estimated using multilevel Poisson models.

Results There were 19,353 singleton cases of CHD among 3,040,952 total births. Excluding, 2,848 (14.7%) cases with a chromosomal anomaly, 683 (3.6%) with a genetic syndrome and 2,639 (15.8%) with extra-cardiac anomalies, there were 13,183 isolated cases. Of these, 7,150 (54.2%, Prevalence = 23.51; 95% CI: 22.97–24.06 per 10,000 total births) were classed as mild, 3,204 (24.3%, Prevalence = 10.54; 95% CI: 10.18–10.91) as moderate and 1,143 (8.7%, Prevalence = 3.76 95%; CI: 3.54–3.98) as severe CHD. There were no significant trends in prevalence over time in mild (RR = 1.04; 95% CI:. 99–1.10; p = 0.096), moderate (RR = 0.99; 95% CI: 0.99–1.00; p = 0.168) or severe CHD (RR = 1.01; 95% CI: 1.00–1.02; p = 0.074), even after adjustment for maternal age. The risk of a pregnancy associated with a mild CHD was significantly greater in women aged 35 and over compared to aged 20–29 (RR = 1.16; 95% CI:1.04–1.29; p = 0.009).

Conclusion There were no significant differences in trends in the prevalence by CHD severity, before or after adjustment for maternal age.

This record has no associated files available for download.

More information

Published date: June 2014
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 367224
URI: http://eprints.soton.ac.uk/id/eprint/367224
ISSN: 1359-2998
PURE UUID: fdce5918-8c26-4790-8eea-a3fb8e1380c4

Catalogue record

Date deposited: 19 Aug 2014 09:31
Last modified: 14 Mar 2024 17:26

Export record

Altmetrics

Contributors

Author: K. Best
Author: E. Draper
Author: J. Kurinczuk
Author: S. Stoianova
Author: D. Tucker
Author: D. Wellesley
Author: J. Rankin

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×