Risk of fracture in Guillain-Barre syndrome
Risk of fracture in Guillain-Barre syndrome
Summary
The aim of this study was to evaluate fracture risk in patients with Guillain-Barré syndrome (GBS). No association with risk of fracture was observed for GBS patients compared with controls. Only GBS patients using pain treatment had a doubled risk of fracture.
Introduction
Symptoms of Guillain-Barré syndrome (GBS) may vary from mild difficulty in walking to complete paralysis, which may increase the risk of fractures. Therefore, the aim of this study was to evaluate fracture risk in patients with GBS.
Methods
We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987–2012). Each patient with GBS was matched by year of birth, sex, and practice, up to six patients without a history of GBS.
Outcome measure was any fracture.
Results
There were no associations between GBS and any fracture, adjusted hazard ratio (AHR) 1.01 (95 % confidence interval [CI] 0.77–1.33), or osteoporotic fracture, AHR 0.76 (95 % CI 0.50–1.17), compared with controls. Stratification to gender, age, and duration since diagnosis did not show an association either. Only for GBS patients using pain treatment, risk of fracture was doubled AHR 1.97 (95 % confidence CI 1.21–3.21) compared with controls. The risk of fracture in GBS patients exposed to pain treatment was equivalent to risk of fracture among controls exposed to pain treatment.
Conclusions
No association with risk of fracture was observed for GBS patients compared with controls. Only GBS patients using pain treatment had a doubled risk of fracture, but their risk was equivalent to fracture risk among controls exposed to pain treatment.
bone, epidemiology, fracture risk, guillain-barre syndrome
1845-1851
Pouwels, S.
3d97460d-5b2e-4ec6-b46f-e82e338cf0c1
de Boer, A.
5621b588-a1e0-4827-8940-89efef278f13
Leufkens, H.G.
6f387677-0ec5-408b-bdbc-7a50d49631b6
Weber, W.E.
af82da4f-31c6-432a-9d69-a578c4275bbb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
van Staa, T.P.
31b8bfb4-4e1b-4a48-a5a6-90ca601b94af
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613
July 2014
Pouwels, S.
3d97460d-5b2e-4ec6-b46f-e82e338cf0c1
de Boer, A.
5621b588-a1e0-4827-8940-89efef278f13
Leufkens, H.G.
6f387677-0ec5-408b-bdbc-7a50d49631b6
Weber, W.E.
af82da4f-31c6-432a-9d69-a578c4275bbb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
van Staa, T.P.
31b8bfb4-4e1b-4a48-a5a6-90ca601b94af
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613
Pouwels, S., de Boer, A., Leufkens, H.G., Weber, W.E., Cooper, C., van Staa, T.P. and de Vries, F.
(2014)
Risk of fracture in Guillain-Barre syndrome.
Osteoporosis International, 25 (7), .
(doi:10.1007/s00198-014-2705-6).
(PMID:24760245)
Abstract
Summary
The aim of this study was to evaluate fracture risk in patients with Guillain-Barré syndrome (GBS). No association with risk of fracture was observed for GBS patients compared with controls. Only GBS patients using pain treatment had a doubled risk of fracture.
Introduction
Symptoms of Guillain-Barré syndrome (GBS) may vary from mild difficulty in walking to complete paralysis, which may increase the risk of fractures. Therefore, the aim of this study was to evaluate fracture risk in patients with GBS.
Methods
We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987–2012). Each patient with GBS was matched by year of birth, sex, and practice, up to six patients without a history of GBS.
Outcome measure was any fracture.
Results
There were no associations between GBS and any fracture, adjusted hazard ratio (AHR) 1.01 (95 % confidence interval [CI] 0.77–1.33), or osteoporotic fracture, AHR 0.76 (95 % CI 0.50–1.17), compared with controls. Stratification to gender, age, and duration since diagnosis did not show an association either. Only for GBS patients using pain treatment, risk of fracture was doubled AHR 1.97 (95 % confidence CI 1.21–3.21) compared with controls. The risk of fracture in GBS patients exposed to pain treatment was equivalent to risk of fracture among controls exposed to pain treatment.
Conclusions
No association with risk of fracture was observed for GBS patients compared with controls. Only GBS patients using pain treatment had a doubled risk of fracture, but their risk was equivalent to fracture risk among controls exposed to pain treatment.
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More information
Published date: July 2014
Keywords:
bone, epidemiology, fracture risk, guillain-barre syndrome
Organisations:
Faculty of Medicine
Identifiers
Local EPrints ID: 367298
URI: http://eprints.soton.ac.uk/id/eprint/367298
ISSN: 0937-941X
PURE UUID: e56edc99-0b94-4be2-856f-753a6f675b48
Catalogue record
Date deposited: 19 Aug 2014 12:00
Last modified: 18 Mar 2024 02:45
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Contributors
Author:
S. Pouwels
Author:
A. de Boer
Author:
H.G. Leufkens
Author:
W.E. Weber
Author:
T.P. van Staa
Author:
F. de Vries
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