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The challenges of genome analysis in the health care setting

The challenges of genome analysis in the health care setting
The challenges of genome analysis in the health care setting
Genome sequencing is now a sufficiently mature and affordable technology for clinical use. Its application promises not only to transform clinicians' diagnostic and predictive ability, but also to improve preventative therapies, surveillance regimes, and tailor patient treatment to an individual's genetic make-up. However, as with any technological advance, there are associated fresh challenges. While some of the ethical, legal and social aspects resulting from the generation of data from genome sequencing are generic, several nuances are unique. Since the UK government recently announced plans to sequence the genomes of 100,000 Health Service patients, and similar initiatives are being considered elsewhere, a discussion of these nuances is timely and needs to go hand in hand with formulation of guidelines and public engagement activities around implementation of sequencing in clinical practice.
2073-4425
576-585
Lucassen, Anneke
2eb85efc-c6e8-4c3f-b963-0290f6c038a5
Houlston, Richard S.
0292e06f-2fd2-4b71-a629-00b288016474
Lucassen, Anneke
2eb85efc-c6e8-4c3f-b963-0290f6c038a5
Houlston, Richard S.
0292e06f-2fd2-4b71-a629-00b288016474

Lucassen, Anneke and Houlston, Richard S. (2014) The challenges of genome analysis in the health care setting. Genes, 5 (3), 576-585. (doi:10.3390/genes5030576). (PMID:25055201)

Record type: Article

Abstract

Genome sequencing is now a sufficiently mature and affordable technology for clinical use. Its application promises not only to transform clinicians' diagnostic and predictive ability, but also to improve preventative therapies, surveillance regimes, and tailor patient treatment to an individual's genetic make-up. However, as with any technological advance, there are associated fresh challenges. While some of the ethical, legal and social aspects resulting from the generation of data from genome sequencing are generic, several nuances are unique. Since the UK government recently announced plans to sequence the genomes of 100,000 Health Service patients, and similar initiatives are being considered elsewhere, a discussion of these nuances is timely and needs to go hand in hand with formulation of guidelines and public engagement activities around implementation of sequencing in clinical practice.

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Published date: 22 July 2014
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 367341
URI: http://eprints.soton.ac.uk/id/eprint/367341
ISSN: 2073-4425
PURE UUID: 9cfa47fd-be73-48ee-9f32-cba01f556e09
ORCID for Anneke Lucassen: ORCID iD orcid.org/0000-0003-3324-4338

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Date deposited: 26 Aug 2014 11:59
Last modified: 18 Feb 2021 16:58

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Contributors

Author: Anneke Lucassen ORCID iD
Author: Richard S. Houlston

University divisions

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