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Association between bile and acid turnover and osteoporosis in postmenopausal women

Association between bile and acid turnover and osteoporosis in postmenopausal women
Association between bile and acid turnover and osteoporosis in postmenopausal women
Objective: The intestinal absorption of vitamin D is linked to bile acid absorption. This link may be abnormal in patients with osteoporosis. The aim of this study was to investigate a possible relation between osteoporosis and bile acid turnover, measured as whole-body Se-75-HCAT retention (WBR), in postmenopausal women.

Patients and methods: Whole-body counts were recorded using an uncollimated gamma camera 3 h and 7 days after oral administration of Se-75-homocholic acid taurine (Se-75-HCAT) in 16 women aged 58-85 years with dual-photon X-ray absorptiometry (DEXA)-proven osteoporosis. WBR was expressed as physical decay-corrected counts at 7 days as a percentage of the counts at 3 h.

Results: Seven patients had unexplained diarrhoea. Six patients (five with diarrhoea) had WBR less than 19%. There was a significant difference in DEXA t-score between women with and without diarrhoea (P<0.02). There was a significant negative correlation (R s=-0.58; P<0.02) between WBR and alcohol consumption rated on a three-point scale: <1, 2-7 and >7 U/week.

Conclusion: Our results indicate an association between osteoporosis and diarrhoea that may be the result of abnormal bile acid turnover. The role of alcohol requires further investigation.

alcohol, bile acid diarrhoea, bile acid turnover, osteoporosis, se-75-homocholic acid taurine
597-600
Hanly, R.
b5cb8a64-b68f-4f84-a61a-b75644d5e597
Ryan, N.
8918f1bd-e65e-41c6-98d3-331868883467
Snelling, H.
1de7774c-e5d0-4efc-b32a-196336cf3209
Walker-Bone, K.
ad7d1336-ed2c-4f39-ade5-da84eb412109
Dizdarevic, S.
7c04afc1-4607-4c56-8fd3-7bd72180d2db
Peters, A.M.
705933f9-c50d-4e07-b147-51645ecc2133
Hanly, R.
b5cb8a64-b68f-4f84-a61a-b75644d5e597
Ryan, N.
8918f1bd-e65e-41c6-98d3-331868883467
Snelling, H.
1de7774c-e5d0-4efc-b32a-196336cf3209
Walker-Bone, K.
ad7d1336-ed2c-4f39-ade5-da84eb412109
Dizdarevic, S.
7c04afc1-4607-4c56-8fd3-7bd72180d2db
Peters, A.M.
705933f9-c50d-4e07-b147-51645ecc2133

Hanly, R., Ryan, N., Snelling, H., Walker-Bone, K., Dizdarevic, S. and Peters, A.M. (2013) Association between bile and acid turnover and osteoporosis in postmenopausal women. Nuclear Medicine Communications, 34 (6), 597-600. (doi:10.1097/MNM.0b013e3283608993). (PMID:23619342)

Record type: Article

Abstract

Objective: The intestinal absorption of vitamin D is linked to bile acid absorption. This link may be abnormal in patients with osteoporosis. The aim of this study was to investigate a possible relation between osteoporosis and bile acid turnover, measured as whole-body Se-75-HCAT retention (WBR), in postmenopausal women.

Patients and methods: Whole-body counts were recorded using an uncollimated gamma camera 3 h and 7 days after oral administration of Se-75-homocholic acid taurine (Se-75-HCAT) in 16 women aged 58-85 years with dual-photon X-ray absorptiometry (DEXA)-proven osteoporosis. WBR was expressed as physical decay-corrected counts at 7 days as a percentage of the counts at 3 h.

Results: Seven patients had unexplained diarrhoea. Six patients (five with diarrhoea) had WBR less than 19%. There was a significant difference in DEXA t-score between women with and without diarrhoea (P<0.02). There was a significant negative correlation (R s=-0.58; P<0.02) between WBR and alcohol consumption rated on a three-point scale: <1, 2-7 and >7 U/week.

Conclusion: Our results indicate an association between osteoporosis and diarrhoea that may be the result of abnormal bile acid turnover. The role of alcohol requires further investigation.

Full text not available from this repository.

More information

Published date: June 2013
Keywords: alcohol, bile acid diarrhoea, bile acid turnover, osteoporosis, se-75-homocholic acid taurine
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 367425
URI: http://eprints.soton.ac.uk/id/eprint/367425
PURE UUID: a30b4edc-a0fa-4ca5-af93-ffda1bac276c
ORCID for K. Walker-Bone: ORCID iD orcid.org/0000-0002-5992-1459

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Date deposited: 02 Sep 2014 09:17
Last modified: 20 Jul 2019 01:08

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Contributors

Author: R. Hanly
Author: N. Ryan
Author: H. Snelling
Author: K. Walker-Bone ORCID iD
Author: S. Dizdarevic
Author: A.M. Peters

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