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The changing spectrum of rheumatic disease in HIV infection

The changing spectrum of rheumatic disease in HIV infection
The changing spectrum of rheumatic disease in HIV infection
Background: Rheumatic manifestations were described soon after human immunodeficiency virus (HIV) was discovered. Since however, combination anti-retroviral therapy (cART) has revolutionized the course of the infection. Less clear is what effect cART has had on rheumatic manifestations.

Sources of data: References were retrieved from the PubMed database using keywords including: ‘HIV’ and ‘arthritis’; ‘myalgia’; ‘arthralgia’ and other disease specific terms, e.g. ‘rheumatoid arthritis’.

Areas of agreement: Musculoskeletal pain was common in HIV and increased with AIDS. Immune restoration inflammatory syndrome on initiation of cART causes de novo autoimmune inflammatory rheumatic disorders. Seronegative inflammatory arthritis with/without axial involvement has been reported widely with HIV.

Areas of controversy: It is unclear if HIV causes these conditions, creates an environmental milieu supportive of these conditions or acts as a marker of other risk factors. It is unclear what effect cART has had on these conditions.

Growing points: Variable diagnostic classification criteria have caused this literature to be poorly comparable.

Areas timely for developing research: High-quality controlled epidemiological studies using standardized criteria are needed among cART users. Treatment of active autoimmune disease in HIV patients needs to be evaluated formally.
hiv, rheumatic manifestations, immune reconstitution inflammatory syndrome, iris, combination anti-retroviral therapy, cart
0007-1420
203-221
Lawson, E.
0d1f437e-e3c7-4b83-ae3e-5b33442add8c
Walker-Bone, K.
ad7d1336-ed2c-4f39-ade5-da84eb412109
Lawson, E.
0d1f437e-e3c7-4b83-ae3e-5b33442add8c
Walker-Bone, K.
ad7d1336-ed2c-4f39-ade5-da84eb412109

Lawson, E. and Walker-Bone, K. (2012) The changing spectrum of rheumatic disease in HIV infection. British Medical Bulletin, 103 (1), 203-221. (doi:10.1093/bmb/lds022). (PMID:22879627)

Record type: Article

Abstract

Background: Rheumatic manifestations were described soon after human immunodeficiency virus (HIV) was discovered. Since however, combination anti-retroviral therapy (cART) has revolutionized the course of the infection. Less clear is what effect cART has had on rheumatic manifestations.

Sources of data: References were retrieved from the PubMed database using keywords including: ‘HIV’ and ‘arthritis’; ‘myalgia’; ‘arthralgia’ and other disease specific terms, e.g. ‘rheumatoid arthritis’.

Areas of agreement: Musculoskeletal pain was common in HIV and increased with AIDS. Immune restoration inflammatory syndrome on initiation of cART causes de novo autoimmune inflammatory rheumatic disorders. Seronegative inflammatory arthritis with/without axial involvement has been reported widely with HIV.

Areas of controversy: It is unclear if HIV causes these conditions, creates an environmental milieu supportive of these conditions or acts as a marker of other risk factors. It is unclear what effect cART has had on these conditions.

Growing points: Variable diagnostic classification criteria have caused this literature to be poorly comparable.

Areas timely for developing research: High-quality controlled epidemiological studies using standardized criteria are needed among cART users. Treatment of active autoimmune disease in HIV patients needs to be evaluated formally.

Full text not available from this repository.

More information

e-pub ahead of print date: August 2012
Published date: September 2012
Keywords: hiv, rheumatic manifestations, immune reconstitution inflammatory syndrome, iris, combination anti-retroviral therapy, cart
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 367444
URI: http://eprints.soton.ac.uk/id/eprint/367444
ISSN: 0007-1420
PURE UUID: 7b388b03-0d85-4576-9099-0ac6de4c60fb
ORCID for K. Walker-Bone: ORCID iD orcid.org/0000-0002-5992-1459

Catalogue record

Date deposited: 02 Sep 2014 10:59
Last modified: 10 Dec 2019 01:49

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Contributors

Author: E. Lawson
Author: K. Walker-Bone ORCID iD

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