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Optimising the assessment of cerebral autoregulation from black box models

Optimising the assessment of cerebral autoregulation from black box models
Optimising the assessment of cerebral autoregulation from black box models
Cerebral autoregulation (CA) mechanisms maintain blood flow approximately stable despite changes in arterial blood pressure. Mathematical models that characterise this system have been used extensively in the quantitative assessment of function/impairment of CA. Using spontaneous fluctuations in arterial blood pressure (ABP) as input and cerebral blood flow velocity (CBFV) as output, the autoregulatory mechanism can be modelled using linear and non-linear approaches, from which indexes can be extracted to provide an overall assessment of CA. Previous studies have considered a single – or at most a couple of measures, making it difficult to compare the performance of different CA parameters. We compare the performance of established autoregulatory parameters and propose novel measures. The key objective is to identify which model and index can best distinguish between normal and impaired CA. To this end 26 recordings of ABP and CBFV from normocapnia and hypercapnia (which temporarily impairs CA) in 13 healthy adults were analysed. In the absence of a ‘gold’ standard for the study of dynamic CA, lower inter- and intra-subject variability of the parameters in relation to the difference between normo- and hypercapnia were considered as criteria for identifying improved measures of CA. Significantly improved performance compared to some conventional approaches was achieved, with the simplest method emerging as probably the most promising for future studies.
blood flow, autoregulation, system identification, modelling
1350-4533
607-612
Angarita-Jaimes, N.
19962628-7901-4967-b4eb-0af4eb027ac0
Kouchakpour, H.
963f8910-fc8f-42ff-89c5-73c0f3254875
Liu, J.
516e902e-000e-4f9c-b9bc-bac18b1f5ade
Panerai, R.B.
5a975266-9864-413e-a6b6-b5a0ddbc3bb9
Simpson, D.M.
53674880-f381-4cc9-8505-6a97eeac3c2a
Angarita-Jaimes, N.
19962628-7901-4967-b4eb-0af4eb027ac0
Kouchakpour, H.
963f8910-fc8f-42ff-89c5-73c0f3254875
Liu, J.
516e902e-000e-4f9c-b9bc-bac18b1f5ade
Panerai, R.B.
5a975266-9864-413e-a6b6-b5a0ddbc3bb9
Simpson, D.M.
53674880-f381-4cc9-8505-6a97eeac3c2a

Angarita-Jaimes, N., Kouchakpour, H., Liu, J., Panerai, R.B. and Simpson, D.M. (2014) Optimising the assessment of cerebral autoregulation from black box models. [in special issue: Cerebral Autoregulation: Measurement and Modelling] Medical Engineering & Physics, 36 (5), 607-612. (doi:10.1016/j.medengphy.2013.12.012). (PMID:24508528)

Record type: Article

Abstract

Cerebral autoregulation (CA) mechanisms maintain blood flow approximately stable despite changes in arterial blood pressure. Mathematical models that characterise this system have been used extensively in the quantitative assessment of function/impairment of CA. Using spontaneous fluctuations in arterial blood pressure (ABP) as input and cerebral blood flow velocity (CBFV) as output, the autoregulatory mechanism can be modelled using linear and non-linear approaches, from which indexes can be extracted to provide an overall assessment of CA. Previous studies have considered a single – or at most a couple of measures, making it difficult to compare the performance of different CA parameters. We compare the performance of established autoregulatory parameters and propose novel measures. The key objective is to identify which model and index can best distinguish between normal and impaired CA. To this end 26 recordings of ABP and CBFV from normocapnia and hypercapnia (which temporarily impairs CA) in 13 healthy adults were analysed. In the absence of a ‘gold’ standard for the study of dynamic CA, lower inter- and intra-subject variability of the parameters in relation to the difference between normo- and hypercapnia were considered as criteria for identifying improved measures of CA. Significantly improved performance compared to some conventional approaches was achieved, with the simplest method emerging as probably the most promising for future studies.

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e-pub ahead of print date: 6 February 2014
Published date: May 2014
Keywords: blood flow, autoregulation, system identification, modelling
Organisations: Inst. Sound & Vibration Research

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Local EPrints ID: 367635
URI: http://eprints.soton.ac.uk/id/eprint/367635
ISSN: 1350-4533
PURE UUID: 0667ab44-19b0-4cf0-8ab5-351d0e19e935

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Date deposited: 04 Aug 2014 10:37
Last modified: 09 Dec 2019 19:57

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Contributors

Author: N. Angarita-Jaimes
Author: H. Kouchakpour
Author: J. Liu
Author: R.B. Panerai
Author: D.M. Simpson

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