The effect of caffeinated versus decaffeinated drinks on overactive bladder: a double-blind, randomized, crossover study
The effect of caffeinated versus decaffeinated drinks on overactive bladder: a double-blind, randomized, crossover study
Purpose: the primary aims of this study were to test the methodology for use in a future randomized control trial and to investigate the effect of drinking caffeinated versus decaffeinated fluids on symptoms of overactive bladder (OAB) in women.
Design: a double-blind, randomized, crossover study was conducted.
Methods: fourteen community-dwelling women newly diagnosed with OAB and a history of caffeine consumption were randomly allocated to group A (14-day caffeinated drink period followed by 14-day decaffeinated drink period) or group B (14-day decaffeinated drink period followed by 14-day caffeinated drink period). The periods were preceded by a 14-day run-in period and interspersed with a 14-day washout period. Primary outcomes were episodes of urgency, frequency, volume per void, and incontinence obtained each period on 3-day bladder diaries. Secondary outcome measures were OAB symptom severity and health-related quality of life (QOL) recorded each period using International Consultation on Incontinence–Overactive Bladder Module (ICIQ-OAB) and ICIQ-OAB–Quality of Life (ICIQ-OABqol) tools. Effects of caffeine reduction were measured each day using visual analogue scales.
Results: eleven participants completed the study. A significant reduction in urgency (P < .01) and frequency (P < .05) of urinary voids on day 3 of the diary, total ICIQ-OAB score (P < .01), and a non-significant directional change for the total ICIQ-OABqol score (P = .065) was found using sign tests for the period of decaffeinated compared to caffeinated drink intake. No significant differences were found for any caffeine withdrawal measures.
Conclusions: despite the small sample size, this pilot study demonstrated that reducing caffeine intake may alleviate the severity of some symptoms and health-related QOL factors associated with OAB. Furthermore, caffeine substitutes were well tolerated
caffeine, overactive bladder women
371-378
Wells, M.J.
fec5901e-bd36-4a26-94ab-b5c16d6ff557
Jamieson, K.
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Markham, T.C.
5725bd17-b480-42c8-aed0-e48e8dbf2101
Green, S.
1075a760-2a75-443c-96c7-194d0d90ede8
Fader, M.
c318f942-2ddb-462a-9183-8b678faf7277
July 2014
Wells, M.J.
fec5901e-bd36-4a26-94ab-b5c16d6ff557
Jamieson, K.
bca786c9-9afe-4695-b946-583dd5b3e288
Markham, T.C.
5725bd17-b480-42c8-aed0-e48e8dbf2101
Green, S.
1075a760-2a75-443c-96c7-194d0d90ede8
Fader, M.
c318f942-2ddb-462a-9183-8b678faf7277
Wells, M.J., Jamieson, K., Markham, T.C., Green, S. and Fader, M.
(2014)
The effect of caffeinated versus decaffeinated drinks on overactive bladder: a double-blind, randomized, crossover study.
Journal of Wound, Ostomy and Continence Nursing, 41 (4), .
(doi:10.1097/WON.0000000000000040).
(PMID:24988515)
Abstract
Purpose: the primary aims of this study were to test the methodology for use in a future randomized control trial and to investigate the effect of drinking caffeinated versus decaffeinated fluids on symptoms of overactive bladder (OAB) in women.
Design: a double-blind, randomized, crossover study was conducted.
Methods: fourteen community-dwelling women newly diagnosed with OAB and a history of caffeine consumption were randomly allocated to group A (14-day caffeinated drink period followed by 14-day decaffeinated drink period) or group B (14-day decaffeinated drink period followed by 14-day caffeinated drink period). The periods were preceded by a 14-day run-in period and interspersed with a 14-day washout period. Primary outcomes were episodes of urgency, frequency, volume per void, and incontinence obtained each period on 3-day bladder diaries. Secondary outcome measures were OAB symptom severity and health-related quality of life (QOL) recorded each period using International Consultation on Incontinence–Overactive Bladder Module (ICIQ-OAB) and ICIQ-OAB–Quality of Life (ICIQ-OABqol) tools. Effects of caffeine reduction were measured each day using visual analogue scales.
Results: eleven participants completed the study. A significant reduction in urgency (P < .01) and frequency (P < .05) of urinary voids on day 3 of the diary, total ICIQ-OAB score (P < .01), and a non-significant directional change for the total ICIQ-OABqol score (P = .065) was found using sign tests for the period of decaffeinated compared to caffeinated drink intake. No significant differences were found for any caffeine withdrawal measures.
Conclusions: despite the small sample size, this pilot study demonstrated that reducing caffeine intake may alleviate the severity of some symptoms and health-related QOL factors associated with OAB. Furthermore, caffeine substitutes were well tolerated
Text
caffeine paper 21 08 13 final version.pdf
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Published date: July 2014
Keywords:
caffeine, overactive bladder women
Organisations:
Faculty of Health Sciences
Identifiers
Local EPrints ID: 367705
URI: http://eprints.soton.ac.uk/id/eprint/367705
ISSN: 1528-3976
PURE UUID: b476650e-ddd4-46d5-93aa-479678652383
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Date deposited: 08 Sep 2014 12:18
Last modified: 14 Mar 2024 17:34
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Contributors
Author:
M.J. Wells
Author:
K. Jamieson
Author:
T.C. Markham
Author:
S. Green
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