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Photodynamic therapy for central serous chorioretinopathy

Photodynamic therapy for central serous chorioretinopathy
Photodynamic therapy for central serous chorioretinopathy
Central serous chorioretinopathy (CSCR) is an idiopathic disorder characterised by detachment of the neurosensory retina due to serous fluid accumulation between the photoreceptor outer segments and the retinal pigment epithelium. There are currently no set guidelines or protocols on its treatment. This study was undertaken to assess the current literature on the efficacy and safety of photodynamic therapy (PDT) as a treatment option for CSCR.MethodsSeven databases (PubMed, CENTRAL, MEDLINE, Web of Science, Embase, Scopus, and The Cochrane Database of Systematic Reviews) were searched without restrictions on time or location. We followed PRISMA guidelines and evaluated quality according to STROBE criteria. In total, 117 citations were identified and 31 studies describing 787 eyes were included for review. Data on indications for PDT in CSCR, dosing regimens of verteprofin PDT (which includes treatment dose of vertoporfin, treatment time, fluence, and spot size), number of treatment sessions, response to treatment, mean length of follow-up, and complications were extracted and analysed.ResultsSince the introduction of PDT for the treatment of CSCR in 2003, there have been three randomised controlled trials (RCTs), one for acute and two chronic CSCR and 28 further studies that met the STROBE criteria that compared the use of PDT with other treatment options. All studies showed short-term efficacy of PDT in CSCR. The studies were of small sample size and lacked sufficient follow-up to draw conclusions on long-term efficacy and safety.ConclusionsThere is sufficient scientific evidence to suggest that PDT may be a useful treatment option for chronic CSCR in the short-term. The review identifies a need for robust RCTs with longer follow-up to ascertain the role of PDT as a useful treatment option for CSCR.
0950-222X
944-957
Erikitola, O.C.
b42d3dc1-cd3c-4beb-ae9f-e275c7a14ea7
Crosby-Nwaobi, R.
e48482fa-50d0-4b82-a752-40a7f1ad94a8
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Sivaprasad, S.
451d388e-50f3-4cfb-b963-e73461eed920
Erikitola, O.C.
b42d3dc1-cd3c-4beb-ae9f-e275c7a14ea7
Crosby-Nwaobi, R.
e48482fa-50d0-4b82-a752-40a7f1ad94a8
Lotery, A.J.
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Sivaprasad, S.
451d388e-50f3-4cfb-b963-e73461eed920

Erikitola, O.C., Crosby-Nwaobi, R., Lotery, A.J. and Sivaprasad, S. (2014) Photodynamic therapy for central serous chorioretinopathy. Eye, 28 (8), 944-957. (doi:10.1038/eye.2014.134). (PMID:24946843)

Record type: Article

Abstract

Central serous chorioretinopathy (CSCR) is an idiopathic disorder characterised by detachment of the neurosensory retina due to serous fluid accumulation between the photoreceptor outer segments and the retinal pigment epithelium. There are currently no set guidelines or protocols on its treatment. This study was undertaken to assess the current literature on the efficacy and safety of photodynamic therapy (PDT) as a treatment option for CSCR.MethodsSeven databases (PubMed, CENTRAL, MEDLINE, Web of Science, Embase, Scopus, and The Cochrane Database of Systematic Reviews) were searched without restrictions on time or location. We followed PRISMA guidelines and evaluated quality according to STROBE criteria. In total, 117 citations were identified and 31 studies describing 787 eyes were included for review. Data on indications for PDT in CSCR, dosing regimens of verteprofin PDT (which includes treatment dose of vertoporfin, treatment time, fluence, and spot size), number of treatment sessions, response to treatment, mean length of follow-up, and complications were extracted and analysed.ResultsSince the introduction of PDT for the treatment of CSCR in 2003, there have been three randomised controlled trials (RCTs), one for acute and two chronic CSCR and 28 further studies that met the STROBE criteria that compared the use of PDT with other treatment options. All studies showed short-term efficacy of PDT in CSCR. The studies were of small sample size and lacked sufficient follow-up to draw conclusions on long-term efficacy and safety.ConclusionsThere is sufficient scientific evidence to suggest that PDT may be a useful treatment option for chronic CSCR in the short-term. The review identifies a need for robust RCTs with longer follow-up to ascertain the role of PDT as a useful treatment option for CSCR.

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Published date: August 2014
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 367802
URI: https://eprints.soton.ac.uk/id/eprint/367802
ISSN: 0950-222X
PURE UUID: 5b5aa7a3-5594-4338-aee6-07d519fce863
ORCID for A.J. Lotery: ORCID iD orcid.org/0000-0001-5541-4305

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Date deposited: 18 Aug 2014 09:50
Last modified: 12 Nov 2019 01:49

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