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Treatment with citalopram, but not with agomelatine, adversely affects sperm parameters: a case report and translational review

Treatment with citalopram, but not with agomelatine, adversely affects sperm parameters: a case report and translational review
Treatment with citalopram, but not with agomelatine, adversely affects sperm parameters: a case report and translational review
BACKGROUND: Adverse effects of antidepressant drug treatmenton sexual function are well documented but the effects of antidepressants on sperm production have not been researched extensively.

METHODS: A narrative of an interventional case report of sperm parameters in a 30-year-old Caucasian man with a diagnosis of mixed depressive and anxiety disorder, who underwent citalopram treatment, followed by agomelatine treatment. Clinical observations prompted a review of the pre-clinical and clinical literature on the effects of antidepressant administration or treatment on sperm production and parameters. Findings from the review are discussed to suggest potential underlying mechanisms.

RESULTS: Abnormal sperm parameters were associated with treatment with the SSRI citalopram. There was an improvement in sperm concentration, motility, progressive motility and sperm morphology following its withdrawal. There was no similar association during subsequent treatment with agomelatine. The clinical observations reflect findings from animal studies, which indicate that antidepressants can have untoward effects on spermatogenesis.

CONCLUSIONS: SSRI treatment can be associated with impaired semen quality. Potential underlying mechanisms include changes in sperm DNA integrity, activation of IDO and shifting tryptophan metabolism. Further studies of the effects of antidepressants on spermatogenesis might benefit from including investigation of changes in IDO activity during antidepressant administration.

0924-2708
125-129
Elnazer, H.Y.
eebf4499-f444-419b-a3ce-35cc09f8bbaf
Baldwin, D.S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e
Elnazer, H.Y.
eebf4499-f444-419b-a3ce-35cc09f8bbaf
Baldwin, D.S.
1beaa192-0ef1-4914-897a-3a49fc2ed15e

Elnazer, H.Y. and Baldwin, D.S. (2014) Treatment with citalopram, but not with agomelatine, adversely affects sperm parameters: a case report and translational review. Acta Neuropsychiatrica, 26 (2), 125-129. (doi:10.1017/neu.2013.60).

Record type: Article

Abstract

BACKGROUND: Adverse effects of antidepressant drug treatmenton sexual function are well documented but the effects of antidepressants on sperm production have not been researched extensively.

METHODS: A narrative of an interventional case report of sperm parameters in a 30-year-old Caucasian man with a diagnosis of mixed depressive and anxiety disorder, who underwent citalopram treatment, followed by agomelatine treatment. Clinical observations prompted a review of the pre-clinical and clinical literature on the effects of antidepressant administration or treatment on sperm production and parameters. Findings from the review are discussed to suggest potential underlying mechanisms.

RESULTS: Abnormal sperm parameters were associated with treatment with the SSRI citalopram. There was an improvement in sperm concentration, motility, progressive motility and sperm morphology following its withdrawal. There was no similar association during subsequent treatment with agomelatine. The clinical observations reflect findings from animal studies, which indicate that antidepressants can have untoward effects on spermatogenesis.

CONCLUSIONS: SSRI treatment can be associated with impaired semen quality. Potential underlying mechanisms include changes in sperm DNA integrity, activation of IDO and shifting tryptophan metabolism. Further studies of the effects of antidepressants on spermatogenesis might benefit from including investigation of changes in IDO activity during antidepressant administration.

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More information

Published date: April 2014
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 367920
URI: http://eprints.soton.ac.uk/id/eprint/367920
ISSN: 0924-2708
PURE UUID: f534b89b-406d-4d8c-b7bf-370a189aa362
ORCID for D.S. Baldwin: ORCID iD orcid.org/0000-0003-3343-0907

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Date deposited: 29 Aug 2014 14:06
Last modified: 18 Feb 2021 16:44

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Contributors

Author: H.Y. Elnazer
Author: D.S. Baldwin ORCID iD

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