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RBFOX2 protein domains and cellular activities

RBFOX2 protein domains and cellular activities
RBFOX2 protein domains and cellular activities
RBFOX2 (RNA-binding protein, Fox-1 homologue 2)/RBM9 (RNA-binding-motif protein 9)/RTA (repressor of tamoxifen action)/HNRBP2 (hexaribonucleotide-binding protein 2) encodes an RNA-binding protein involved in tissue specific alternative splicing regulation and steroid receptors transcriptional activity. Its ability to regulate specific splicing profiles depending on context has been related to different expression levels of the RBFOX2 protein itself and that of other splicing regulatory proteins involved in the shared modulation of specific genes splicing. However, this cannot be the sole explanation as to why RBFOX2 plays a widespread role in numerous cellular mechanisms from development to cell survival dependent on cell/tissue type. RBFOX2 isoforms with altered protein domains exist. In the present article, we describe the main RBFOX2 protein domains, their importance in the context of splicing and transcriptional regulation and we propose that RBFOX2 isoform distribution may play a fundamental role in RBFOX2-specific cellular effects.

0300-5127
1180-1183
Arya, Anurada D.
5c72de44-1987-46d5-959e-3921c4ce1700
Wilson, David I.
1500fca1-7082-4271-95f4-691f1d1252a2
Baralle, Diana
faac16e5-7928-4801-9811-8b3a9ea4bb91
Raponi, Michaela
f465e77f-b9bf-4c32-80d6-43c0787542b9
Arya, Anurada D.
5c72de44-1987-46d5-959e-3921c4ce1700
Wilson, David I.
1500fca1-7082-4271-95f4-691f1d1252a2
Baralle, Diana
faac16e5-7928-4801-9811-8b3a9ea4bb91
Raponi, Michaela
f465e77f-b9bf-4c32-80d6-43c0787542b9

Arya, Anurada D., Wilson, David I., Baralle, Diana and Raponi, Michaela (2014) RBFOX2 protein domains and cellular activities. Biochemical Society Transactions, 42 (4), 1180-1183. (doi:10.1042/BST20140050).

Record type: Article

Abstract

RBFOX2 (RNA-binding protein, Fox-1 homologue 2)/RBM9 (RNA-binding-motif protein 9)/RTA (repressor of tamoxifen action)/HNRBP2 (hexaribonucleotide-binding protein 2) encodes an RNA-binding protein involved in tissue specific alternative splicing regulation and steroid receptors transcriptional activity. Its ability to regulate specific splicing profiles depending on context has been related to different expression levels of the RBFOX2 protein itself and that of other splicing regulatory proteins involved in the shared modulation of specific genes splicing. However, this cannot be the sole explanation as to why RBFOX2 plays a widespread role in numerous cellular mechanisms from development to cell survival dependent on cell/tissue type. RBFOX2 isoforms with altered protein domains exist. In the present article, we describe the main RBFOX2 protein domains, their importance in the context of splicing and transcriptional regulation and we propose that RBFOX2 isoform distribution may play a fundamental role in RBFOX2-specific cellular effects.

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More information

Published date: 1 August 2014
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 368013
URI: http://eprints.soton.ac.uk/id/eprint/368013
ISSN: 0300-5127
PURE UUID: f5208f2c-bfad-409b-b2d8-ce8bf3346716
ORCID for Diana Baralle: ORCID iD orcid.org/0000-0003-3217-4833

Catalogue record

Date deposited: 28 Aug 2014 10:15
Last modified: 15 Mar 2024 03:30

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Contributors

Author: Anurada D. Arya
Author: David I. Wilson
Author: Diana Baralle ORCID iD
Author: Michaela Raponi

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