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Changes in NGF/c-Fos colocalization in specific limbic structures of juvenile and aged rats after open field stimulation

Changes in NGF/c-Fos colocalization in specific limbic structures of juvenile and aged rats after open field stimulation
Changes in NGF/c-Fos colocalization in specific limbic structures of juvenile and aged rats after open field stimulation
Changes in NGF release during stressful events have been associated with the activation of neurons expressing NGF receptors. This study examined the influence of acute stress-induced stimulation on NGF/c-Fos colocalization in the following limbic regions: the paraventricular (PV) nucleus of the hypothalamus, medial (MeA) nucleus of the amygdala, and CA3 hippocampus. Juvenile (P21) and aged rats (P360) were exposed to a 15-minute acute open field (OF) test. Double immunofluorescence staining, used to detect NGF-ir and c-Fos-ir cells, revealed a higher percentage of NGF/c-Fos-ir neurons in the P21 control group than in the P360 control group. Under OF acute stimulation, a statistically significant (p < 0.05) increase of NGF/c-Fos level in CA3 of juvenile animals and in PV and CA3 of the aged rats was observed. These observations indicate that the investigated structures in both age groups show a different response to acute OF stimulation. Acute OF affects the levels of NGF/c-Fos more significantly in aged rats.
0015-5659
129-134
Badowska-Szalewska, E.
a2e1b403-73cb-4ea1-9321-8a20c0f4f17d
Klejbor, I.
1b4f491a-a035-4353-b3b1-d552fa9ffda4
Cecot, T.
eb39253c-283b-4000-af47-5f898749079d
Domaradzka-Pytel, B.
3265150b-a5db-419f-b5f0-bfb4452028c8
Ludkiewicz, B.
72602c6a-a1fa-4a3a-afc2-6ed842506cf9
Moryś, J.
fdad8181-0ae6-4842-91b1-b889a2ab52fb
Badowska-Szalewska, E.
a2e1b403-73cb-4ea1-9321-8a20c0f4f17d
Klejbor, I.
1b4f491a-a035-4353-b3b1-d552fa9ffda4
Cecot, T.
eb39253c-283b-4000-af47-5f898749079d
Domaradzka-Pytel, B.
3265150b-a5db-419f-b5f0-bfb4452028c8
Ludkiewicz, B.
72602c6a-a1fa-4a3a-afc2-6ed842506cf9
Moryś, J.
fdad8181-0ae6-4842-91b1-b889a2ab52fb

Badowska-Szalewska, E., Klejbor, I., Cecot, T., Domaradzka-Pytel, B., Ludkiewicz, B. and Moryś, J. (2009) Changes in NGF/c-Fos colocalization in specific limbic structures of juvenile and aged rats after open field stimulation. Folia Morphologica, 68 (3), 129-134. (PMID:19722155)

Record type: Article

Abstract

Changes in NGF release during stressful events have been associated with the activation of neurons expressing NGF receptors. This study examined the influence of acute stress-induced stimulation on NGF/c-Fos colocalization in the following limbic regions: the paraventricular (PV) nucleus of the hypothalamus, medial (MeA) nucleus of the amygdala, and CA3 hippocampus. Juvenile (P21) and aged rats (P360) were exposed to a 15-minute acute open field (OF) test. Double immunofluorescence staining, used to detect NGF-ir and c-Fos-ir cells, revealed a higher percentage of NGF/c-Fos-ir neurons in the P21 control group than in the P360 control group. Under OF acute stimulation, a statistically significant (p < 0.05) increase of NGF/c-Fos level in CA3 of juvenile animals and in PV and CA3 of the aged rats was observed. These observations indicate that the investigated structures in both age groups show a different response to acute OF stimulation. Acute OF affects the levels of NGF/c-Fos more significantly in aged rats.

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Published date: August 2009
Organisations: Faculty of Medicine

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Local EPrints ID: 368558
URI: https://eprints.soton.ac.uk/id/eprint/368558
ISSN: 0015-5659
PURE UUID: d4637c30-31f4-45f0-9bd5-c38a8c085cf0
ORCID for T. Cecot: ORCID iD orcid.org/0000-0002-3944-654X

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Date deposited: 17 Sep 2014 15:12
Last modified: 18 Jul 2017 01:45

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Contributors

Author: E. Badowska-Szalewska
Author: I. Klejbor
Author: T. Cecot ORCID iD
Author: B. Domaradzka-Pytel
Author: B. Ludkiewicz
Author: J. Moryś

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