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Stress-induced changes of interleukin-1beta within the limbic system in the rat

Stress-induced changes of interleukin-1beta within the limbic system in the rat
Stress-induced changes of interleukin-1beta within the limbic system in the rat
The aim of this study was to investigate the influence of two periods of life, namely P28 and P360, on the changes in interleukin-1beta (IL-1beta) immunoreactivity (-ir) in the hippocampus (CA1, CA3, DG) and amygdala (central-CeA, medial-MeA) caused by acute and repeated open field (OF), or by forced swim (FS) exposition. Rats were divided into groups: non-stressed, exposed to acute (one-time for 15 min) and chronic stressors (21 days for 15 min daily). We found IL-1beta-ir in the control group to be higher in P360 than in P28. In P28, under OF and FS exposure, IL-1beta-ir in the CeA remained unaltered but increased in the MeA and in the hippocampus after acute and chronic stress. In P360 no changes were observed in the IL-1beta-ir level after acute and chronic stimulation. These data demonstrate that only the levels of IL-1beta-ir in juvenile rat brains are affected by FS and OF. Additionally, there was no significant difference between FS and OF stimulation in IL-1beta-ir.
0015-5659
119-128
Badowska-Szalewska, E.
a2e1b403-73cb-4ea1-9321-8a20c0f4f17d
Klejbor, I.
1b4f491a-a035-4353-b3b1-d552fa9ffda4
Sidor-Kaczmarek, J.
8ad3a2f2-e03a-468e-b122-701d2d7fada8
Cecot, T.
eb39253c-283b-4000-af47-5f898749079d
Lietzau, G.
55aa1d11-82bf-4724-883e-c44a744566f3
Spodnik, J. H.
5da83eea-d696-4a24-b284-afaec4dc14a6
Moryś, J.
fdad8181-0ae6-4842-91b1-b889a2ab52fb
Badowska-Szalewska, E.
a2e1b403-73cb-4ea1-9321-8a20c0f4f17d
Klejbor, I.
1b4f491a-a035-4353-b3b1-d552fa9ffda4
Sidor-Kaczmarek, J.
8ad3a2f2-e03a-468e-b122-701d2d7fada8
Cecot, T.
eb39253c-283b-4000-af47-5f898749079d
Lietzau, G.
55aa1d11-82bf-4724-883e-c44a744566f3
Spodnik, J. H.
5da83eea-d696-4a24-b284-afaec4dc14a6
Moryś, J.
fdad8181-0ae6-4842-91b1-b889a2ab52fb

Badowska-Szalewska, E., Klejbor, I., Sidor-Kaczmarek, J., Cecot, T., Lietzau, G., Spodnik, J. H. and Moryś, J. (2009) Stress-induced changes of interleukin-1beta within the limbic system in the rat. Folia Morphologica, 68 (3), 119-128. (PMID:19722154)

Record type: Article

Abstract

The aim of this study was to investigate the influence of two periods of life, namely P28 and P360, on the changes in interleukin-1beta (IL-1beta) immunoreactivity (-ir) in the hippocampus (CA1, CA3, DG) and amygdala (central-CeA, medial-MeA) caused by acute and repeated open field (OF), or by forced swim (FS) exposition. Rats were divided into groups: non-stressed, exposed to acute (one-time for 15 min) and chronic stressors (21 days for 15 min daily). We found IL-1beta-ir in the control group to be higher in P360 than in P28. In P28, under OF and FS exposure, IL-1beta-ir in the CeA remained unaltered but increased in the MeA and in the hippocampus after acute and chronic stress. In P360 no changes were observed in the IL-1beta-ir level after acute and chronic stimulation. These data demonstrate that only the levels of IL-1beta-ir in juvenile rat brains are affected by FS and OF. Additionally, there was no significant difference between FS and OF stimulation in IL-1beta-ir.

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Published date: August 2009
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 368559
URI: https://eprints.soton.ac.uk/id/eprint/368559
ISSN: 0015-5659
PURE UUID: 4f0bc39c-b71c-44bd-bf60-d7874b19d232
ORCID for T. Cecot: ORCID iD orcid.org/0000-0002-3944-654X

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Date deposited: 17 Sep 2014 15:10
Last modified: 18 Jul 2017 01:45

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Contributors

Author: E. Badowska-Szalewska
Author: I. Klejbor
Author: J. Sidor-Kaczmarek
Author: T. Cecot ORCID iD
Author: G. Lietzau
Author: J. H. Spodnik
Author: J. Moryś

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