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Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation.

Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation.
Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation.
Nitrite has emerged as an important bioactive molecule that can be biotransformed to nitric oxide (NO) related metabolites in normoxia and reduced to NO under hypoxic and acidic conditions to exert vasodilatory effects and confer a variety of other benefits to the cardiovascular system. Abundant research is currently underway to understand the mechanisms involved and define the role of nitrite in health and disease. In this review we discuss the impact of nitrite and dietary nitrate on vascular function and the potential therapeutic role of nitrite in acute heart failure.
0163-7258
303-320
Bailey, J.C.
be7a3e08-9047-4c37-8683-26927d5a2803
Feelisch, M.
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Horowitz, J.D.
4f3b1550-9d56-4d5e-a160-5a5db6483735
Frenneaux, M.P.
0212dec4-bb21-40a8-8f02-e4fd5a3750a6
Madhani, M.
9facf752-474f-46c2-a03b-d4fd966749ce
Bailey, J.C.
be7a3e08-9047-4c37-8683-26927d5a2803
Feelisch, M.
8c1b9965-8614-4e85-b2c6-458a2e17eafd
Horowitz, J.D.
4f3b1550-9d56-4d5e-a160-5a5db6483735
Frenneaux, M.P.
0212dec4-bb21-40a8-8f02-e4fd5a3750a6
Madhani, M.
9facf752-474f-46c2-a03b-d4fd966749ce

Bailey, J.C., Feelisch, M., Horowitz, J.D., Frenneaux, M.P. and Madhani, M. (2014) Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation. Pharmacology & Therapeutics, 144, 303-320. (doi:10.1016/j.pharmthera.2014.06.009). (PMID:24992304)

Record type: Article

Abstract

Nitrite has emerged as an important bioactive molecule that can be biotransformed to nitric oxide (NO) related metabolites in normoxia and reduced to NO under hypoxic and acidic conditions to exert vasodilatory effects and confer a variety of other benefits to the cardiovascular system. Abundant research is currently underway to understand the mechanisms involved and define the role of nitrite in health and disease. In this review we discuss the impact of nitrite and dietary nitrate on vascular function and the potential therapeutic role of nitrite in acute heart failure.

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Published date: 30 June 2014
Organisations: Faculty of Medicine

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Local EPrints ID: 368570
URI: http://eprints.soton.ac.uk/id/eprint/368570
ISSN: 0163-7258
PURE UUID: 00b97182-4c8e-414d-bbef-ef8f70fb4191
ORCID for M. Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

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Date deposited: 04 Sep 2014 12:15
Last modified: 18 Feb 2021 17:18

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Contributors

Author: J.C. Bailey
Author: M. Feelisch ORCID iD
Author: J.D. Horowitz
Author: M.P. Frenneaux
Author: M. Madhani

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