The University of Southampton
University of Southampton Institutional Repository

Serological markers predicting tuberculosis in human immunodeficiency virus-infected patients

Serological markers predicting tuberculosis in human immunodeficiency virus-infected patients
Serological markers predicting tuberculosis in human immunodeficiency virus-infected patients
SETTING: Human immunodeficiency virus (HIV)-positive patients retrospectively identified at the Hospital of Bari, Italy, with diagnosis of tuberculosis (TB) (n = 30) or non-tuberculous pneumonia (n = 29). Serum samples drawn at the time of diagnosis and one year before. Anti-purified protein derivative (PPD) and anti-diacyltrehalose (DAT) serum antibodies quantified by ELISA assay.

OBJECTIVE: Since TB patients with HIV infection may present with elevated serum antibodies against Mycobacterium tuberculosis, we hypothesized that TB-specific antibody markers might predict TB in these subjects.

DESIGN: A retrospective study was designed to assess the presence of M. tuberculosis-specific antibodies in HIV-positive patients developing TB.

RESULTS: Of 30 HIV-positive TB patients, 24 (80%) had anti-PPD or anti-DAT antibodies at the time of TB diagnosis, and 20 (67%) one year before. In a sub-population of 16 of the 30 HIV-positive subjects, positivity for anti-PPD or anti-DAT antibodies one year before TB diagnosis was higher (11/16, 69%) than for the PPD skin test (4/16, 25%, P < 0.01). Antibody tests were specific for TB since positivity rates were lower both in patients with non-tuberculous pneumonia (P < 0.01) and in those with M. avium infection (P < 0.05).

CONCLUSION: Antibody markers may predict TB in HIV-positive subjects, including those with negative PPD skin test.
1027-3719
435-440
Amicosante, M.
deeb6cc8-e796-4c25-8e92-6b79000d737c
Richeldi, L.
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26
Monno, L.
441cf3d0-7b98-4b75-a937-3cd68cedb158
Cuboni, A.
9b48f489-c9c0-4feb-b13d-62de7531e72b
Tartoni, P.L.
5c3c548c-315a-4958-9f1a-374412ffbb02
Angarano, G.
89fccb01-fe5f-47a5-8212-4bb0f1749129
Orefici, G.
15ddb2a3-f449-487d-ae8a-5b551496c171
Saltini, C.
511217a8-2901-4ca3-bbdf-b54611e4acc2
Amicosante, M.
deeb6cc8-e796-4c25-8e92-6b79000d737c
Richeldi, L.
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26
Monno, L.
441cf3d0-7b98-4b75-a937-3cd68cedb158
Cuboni, A.
9b48f489-c9c0-4feb-b13d-62de7531e72b
Tartoni, P.L.
5c3c548c-315a-4958-9f1a-374412ffbb02
Angarano, G.
89fccb01-fe5f-47a5-8212-4bb0f1749129
Orefici, G.
15ddb2a3-f449-487d-ae8a-5b551496c171
Saltini, C.
511217a8-2901-4ca3-bbdf-b54611e4acc2

Amicosante, M., Richeldi, L., Monno, L., Cuboni, A., Tartoni, P.L., Angarano, G., Orefici, G. and Saltini, C. (1997) Serological markers predicting tuberculosis in human immunodeficiency virus-infected patients. International Journal of Tuberculosis and Lung Disease, 1 (5), 435-440. (PMID:9441098)

Record type: Article

Abstract

SETTING: Human immunodeficiency virus (HIV)-positive patients retrospectively identified at the Hospital of Bari, Italy, with diagnosis of tuberculosis (TB) (n = 30) or non-tuberculous pneumonia (n = 29). Serum samples drawn at the time of diagnosis and one year before. Anti-purified protein derivative (PPD) and anti-diacyltrehalose (DAT) serum antibodies quantified by ELISA assay.

OBJECTIVE: Since TB patients with HIV infection may present with elevated serum antibodies against Mycobacterium tuberculosis, we hypothesized that TB-specific antibody markers might predict TB in these subjects.

DESIGN: A retrospective study was designed to assess the presence of M. tuberculosis-specific antibodies in HIV-positive patients developing TB.

RESULTS: Of 30 HIV-positive TB patients, 24 (80%) had anti-PPD or anti-DAT antibodies at the time of TB diagnosis, and 20 (67%) one year before. In a sub-population of 16 of the 30 HIV-positive subjects, positivity for anti-PPD or anti-DAT antibodies one year before TB diagnosis was higher (11/16, 69%) than for the PPD skin test (4/16, 25%, P < 0.01). Antibody tests were specific for TB since positivity rates were lower both in patients with non-tuberculous pneumonia (P < 0.01) and in those with M. avium infection (P < 0.05).

CONCLUSION: Antibody markers may predict TB in HIV-positive subjects, including those with negative PPD skin test.

Full text not available from this repository.

More information

Published date: October 1997
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 368935
URI: https://eprints.soton.ac.uk/id/eprint/368935
ISSN: 1027-3719
PURE UUID: 78be1777-132e-45f1-a0bd-89e2326f6a31

Catalogue record

Date deposited: 23 Sep 2014 11:39
Last modified: 18 Jul 2017 01:41

Export record

Contributors

Author: M. Amicosante
Author: L. Richeldi
Author: L. Monno
Author: A. Cuboni
Author: P.L. Tartoni
Author: G. Angarano
Author: G. Orefici
Author: C. Saltini

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of https://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×