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Serological markers predicting tuberculosis in human immunodeficiency virus-infected patients

Serological markers predicting tuberculosis in human immunodeficiency virus-infected patients
Serological markers predicting tuberculosis in human immunodeficiency virus-infected patients
SETTING: Human immunodeficiency virus (HIV)-positive patients retrospectively identified at the Hospital of Bari, Italy, with diagnosis of tuberculosis (TB) (n = 30) or non-tuberculous pneumonia (n = 29). Serum samples drawn at the time of diagnosis and one year before. Anti-purified protein derivative (PPD) and anti-diacyltrehalose (DAT) serum antibodies quantified by ELISA assay.

OBJECTIVE: Since TB patients with HIV infection may present with elevated serum antibodies against Mycobacterium tuberculosis, we hypothesized that TB-specific antibody markers might predict TB in these subjects.

DESIGN: A retrospective study was designed to assess the presence of M. tuberculosis-specific antibodies in HIV-positive patients developing TB.

RESULTS: Of 30 HIV-positive TB patients, 24 (80%) had anti-PPD or anti-DAT antibodies at the time of TB diagnosis, and 20 (67%) one year before. In a sub-population of 16 of the 30 HIV-positive subjects, positivity for anti-PPD or anti-DAT antibodies one year before TB diagnosis was higher (11/16, 69%) than for the PPD skin test (4/16, 25%, P < 0.01). Antibody tests were specific for TB since positivity rates were lower both in patients with non-tuberculous pneumonia (P < 0.01) and in those with M. avium infection (P < 0.05).

CONCLUSION: Antibody markers may predict TB in HIV-positive subjects, including those with negative PPD skin test.
1027-3719
435-440
Amicosante, M.
deeb6cc8-e796-4c25-8e92-6b79000d737c
Richeldi, L.
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26
Monno, L.
441cf3d0-7b98-4b75-a937-3cd68cedb158
Cuboni, A.
9b48f489-c9c0-4feb-b13d-62de7531e72b
Tartoni, P.L.
5c3c548c-315a-4958-9f1a-374412ffbb02
Angarano, G.
89fccb01-fe5f-47a5-8212-4bb0f1749129
Orefici, G.
15ddb2a3-f449-487d-ae8a-5b551496c171
Saltini, C.
511217a8-2901-4ca3-bbdf-b54611e4acc2
Amicosante, M.
deeb6cc8-e796-4c25-8e92-6b79000d737c
Richeldi, L.
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26
Monno, L.
441cf3d0-7b98-4b75-a937-3cd68cedb158
Cuboni, A.
9b48f489-c9c0-4feb-b13d-62de7531e72b
Tartoni, P.L.
5c3c548c-315a-4958-9f1a-374412ffbb02
Angarano, G.
89fccb01-fe5f-47a5-8212-4bb0f1749129
Orefici, G.
15ddb2a3-f449-487d-ae8a-5b551496c171
Saltini, C.
511217a8-2901-4ca3-bbdf-b54611e4acc2

Amicosante, M., Richeldi, L., Monno, L., Cuboni, A., Tartoni, P.L., Angarano, G., Orefici, G. and Saltini, C. (1997) Serological markers predicting tuberculosis in human immunodeficiency virus-infected patients. International Journal of Tuberculosis and Lung Disease, 1 (5), 435-440. (PMID:9441098)

Record type: Article

Abstract

SETTING: Human immunodeficiency virus (HIV)-positive patients retrospectively identified at the Hospital of Bari, Italy, with diagnosis of tuberculosis (TB) (n = 30) or non-tuberculous pneumonia (n = 29). Serum samples drawn at the time of diagnosis and one year before. Anti-purified protein derivative (PPD) and anti-diacyltrehalose (DAT) serum antibodies quantified by ELISA assay.

OBJECTIVE: Since TB patients with HIV infection may present with elevated serum antibodies against Mycobacterium tuberculosis, we hypothesized that TB-specific antibody markers might predict TB in these subjects.

DESIGN: A retrospective study was designed to assess the presence of M. tuberculosis-specific antibodies in HIV-positive patients developing TB.

RESULTS: Of 30 HIV-positive TB patients, 24 (80%) had anti-PPD or anti-DAT antibodies at the time of TB diagnosis, and 20 (67%) one year before. In a sub-population of 16 of the 30 HIV-positive subjects, positivity for anti-PPD or anti-DAT antibodies one year before TB diagnosis was higher (11/16, 69%) than for the PPD skin test (4/16, 25%, P < 0.01). Antibody tests were specific for TB since positivity rates were lower both in patients with non-tuberculous pneumonia (P < 0.01) and in those with M. avium infection (P < 0.05).

CONCLUSION: Antibody markers may predict TB in HIV-positive subjects, including those with negative PPD skin test.

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More information

Published date: October 1997
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 368935
URI: http://eprints.soton.ac.uk/id/eprint/368935
ISSN: 1027-3719
PURE UUID: 78be1777-132e-45f1-a0bd-89e2326f6a31

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Date deposited: 23 Sep 2014 11:39
Last modified: 22 Jul 2022 19:08

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Contributors

Author: M. Amicosante
Author: L. Richeldi
Author: L. Monno
Author: A. Cuboni
Author: P.L. Tartoni
Author: G. Angarano
Author: G. Orefici
Author: C. Saltini

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