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Interaction of genetic and exposure factors in the prevalence of berylliosis

Interaction of genetic and exposure factors in the prevalence of berylliosis
Interaction of genetic and exposure factors in the prevalence of berylliosis
Prevalence of berylliosis, a lung disorder driven by the activation of beryllium-specific T cells, is associated with a major histocompatibility complex (MHC) class II marker (HLA-DPB1Glu69) and with the type of industrial exposure. We evaluated the interaction between marker and exposure in a beryllium-exposed population in which the prevalence of berylliosis was associated with machining beryllium. The presence of the marker was associated with higher prevalence (HLA-DPB1Glu69-positive machinists 25%; HLA-DPB1Glu69-negative machinists 3.2%, P = 0.05) and predicted berylliosis independent of machining history (odds ratios 11.8 and 10.1). The study shows that in berylliosis the carrier status of a genetic susceptibility factor adds to the effect of process-related risk factors.
berylliosis, HLA, genetic susceptibility, occupational exposures, BAL
0271-3586
337-340
Richeldi, Luca
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26
Kreiss, Kathleen
1f59c6c2-9d38-4660-8082-8f9c84e13202
Mroz, Margaret M.
ecb6eae2-9fe7-48af-aa71-c128902b6b18
Zhen, Boguang
8ddfe31e-7261-4031-904f-bbda2a7fcd6d
Tartoni, Pierluigi
839d9811-d4fa-417f-8348-e764c6c1af06
Saltini, Cesare
a1b4f1f1-bda2-4160-80fc-44db14a07f6a
Richeldi, Luca
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26
Kreiss, Kathleen
1f59c6c2-9d38-4660-8082-8f9c84e13202
Mroz, Margaret M.
ecb6eae2-9fe7-48af-aa71-c128902b6b18
Zhen, Boguang
8ddfe31e-7261-4031-904f-bbda2a7fcd6d
Tartoni, Pierluigi
839d9811-d4fa-417f-8348-e764c6c1af06
Saltini, Cesare
a1b4f1f1-bda2-4160-80fc-44db14a07f6a

Richeldi, Luca, Kreiss, Kathleen, Mroz, Margaret M., Zhen, Boguang, Tartoni, Pierluigi and Saltini, Cesare (1997) Interaction of genetic and exposure factors in the prevalence of berylliosis. American Journal of Industrial Medicine, 32 (4), 337-340. (PMID:9258386)

Record type: Article

Abstract

Prevalence of berylliosis, a lung disorder driven by the activation of beryllium-specific T cells, is associated with a major histocompatibility complex (MHC) class II marker (HLA-DPB1Glu69) and with the type of industrial exposure. We evaluated the interaction between marker and exposure in a beryllium-exposed population in which the prevalence of berylliosis was associated with machining beryllium. The presence of the marker was associated with higher prevalence (HLA-DPB1Glu69-positive machinists 25%; HLA-DPB1Glu69-negative machinists 3.2%, P = 0.05) and predicted berylliosis independent of machining history (odds ratios 11.8 and 10.1). The study shows that in berylliosis the carrier status of a genetic susceptibility factor adds to the effect of process-related risk factors.

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More information

Published date: October 1997
Keywords: berylliosis, HLA, genetic susceptibility, occupational exposures, BAL
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 368936
URI: https://eprints.soton.ac.uk/id/eprint/368936
ISSN: 0271-3586
PURE UUID: c6d1a065-37e9-4c17-adc6-c0ab514493fc

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Date deposited: 25 Sep 2014 13:16
Last modified: 18 Jul 2017 01:41

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Contributors

Author: Luca Richeldi
Author: Kathleen Kreiss
Author: Margaret M. Mroz
Author: Boguang Zhen
Author: Pierluigi Tartoni
Author: Cesare Saltini

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