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Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections

Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections
Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections
The triggering receptor expressed on myeloid cells (TREM)-1 is a recently described molecule, which plays an important role in myeloid cell-activated inflammatory responses. TREM-1 is expressed on blood neutrophils and monocytes, and also on alveolar macrophages, thus suggesting a potential role in lung inflammatory responses against infections. To investigate the differential expression of TREM-1 in lung infections, its levels were assessed in bronchoalveolar lavage specimens from patients with community-acquired pneumonia or tuberculosis. TREM-1 was also investigated in patients with interstitial lung diseases, as a model of noninfectious inflammatory disease of the lung. TREM-1 expression was significantly increased in lung neutrophils and in lung macrophages of patients with pneumonia (n=7; 387.9+/-61.4 and 660.5+/-18.3, respectively) compared with patients with pulmonary tuberculosis (n=7; 59.2+/-13.1 and 80.6+/-291.2) and patients with interstitial lung diseases (n=10; 91.8+/-23.3 and 123.9+/-22.8). In contrast, TREM-1 expression on peripheral blood neutrophils was no different among the three groups. In conclusion, these data suggest that triggering receptor expressed on myeloid cells-1 is selectively expressed in the lungs of patients with pneumonia caused by extracellular bacteria and not in patients with tuberculosis, providing a potential marker for differential diagnosis.
bacterial infections, bronchoalveolar lavage, neutrophils, pneumonia, triggering receptor expressed on myeloid cells?1, tuberculosis
0903-1936
247-50
Richeldi, L.
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26
Mariani, M.
23068be6-d16b-4102-b294-cd80b59e20a7
Losi, M.
5d48476e-5760-47eb-bd74-573132186a06
Maselli, F.
e002bae5-284a-49b8-bdad-589d32b71ee8
Corbetta, L.
35d92282-409b-413d-8a75-142ade07f98e
Buonsanti, C.
cc4f7ba0-638d-403b-ae3e-9d63092bd7fa
Colonna, M.
6c45a6d7-f0c5-48e1-96ae-924fb0627674
Sinigaglia, F.
82a01e01-a6b0-4af6-959d-6fec01fffbc8
Panina-Bordignon, P.
2a507f85-c3b3-4b64-87e5-411781799712
Fabbri, L.M.
bcd21e7a-25ed-458d-8cbf-500e45b79a1f
Richeldi, L.
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26
Mariani, M.
23068be6-d16b-4102-b294-cd80b59e20a7
Losi, M.
5d48476e-5760-47eb-bd74-573132186a06
Maselli, F.
e002bae5-284a-49b8-bdad-589d32b71ee8
Corbetta, L.
35d92282-409b-413d-8a75-142ade07f98e
Buonsanti, C.
cc4f7ba0-638d-403b-ae3e-9d63092bd7fa
Colonna, M.
6c45a6d7-f0c5-48e1-96ae-924fb0627674
Sinigaglia, F.
82a01e01-a6b0-4af6-959d-6fec01fffbc8
Panina-Bordignon, P.
2a507f85-c3b3-4b64-87e5-411781799712
Fabbri, L.M.
bcd21e7a-25ed-458d-8cbf-500e45b79a1f

Richeldi, L., Mariani, M., Losi, M., Maselli, F., Corbetta, L., Buonsanti, C., Colonna, M., Sinigaglia, F., Panina-Bordignon, P. and Fabbri, L.M. (2004) Triggering receptor expressed on myeloid cells: role in the diagnosis of lung infections. European Respiratory Journal, 24 (2), 247-50. (doi:10.1183/09031936.04.00014204). (PMID:15332392)

Record type: Article

Abstract

The triggering receptor expressed on myeloid cells (TREM)-1 is a recently described molecule, which plays an important role in myeloid cell-activated inflammatory responses. TREM-1 is expressed on blood neutrophils and monocytes, and also on alveolar macrophages, thus suggesting a potential role in lung inflammatory responses against infections. To investigate the differential expression of TREM-1 in lung infections, its levels were assessed in bronchoalveolar lavage specimens from patients with community-acquired pneumonia or tuberculosis. TREM-1 was also investigated in patients with interstitial lung diseases, as a model of noninfectious inflammatory disease of the lung. TREM-1 expression was significantly increased in lung neutrophils and in lung macrophages of patients with pneumonia (n=7; 387.9+/-61.4 and 660.5+/-18.3, respectively) compared with patients with pulmonary tuberculosis (n=7; 59.2+/-13.1 and 80.6+/-291.2) and patients with interstitial lung diseases (n=10; 91.8+/-23.3 and 123.9+/-22.8). In contrast, TREM-1 expression on peripheral blood neutrophils was no different among the three groups. In conclusion, these data suggest that triggering receptor expressed on myeloid cells-1 is selectively expressed in the lungs of patients with pneumonia caused by extracellular bacteria and not in patients with tuberculosis, providing a potential marker for differential diagnosis.

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Published date: 1 August 2004
Keywords: bacterial infections, bronchoalveolar lavage, neutrophils, pneumonia, triggering receptor expressed on myeloid cells?1, tuberculosis
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 368957
URI: https://eprints.soton.ac.uk/id/eprint/368957
ISSN: 0903-1936
PURE UUID: fd8d82d2-5242-4116-a516-8007be37605c

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Date deposited: 10 Oct 2014 10:52
Last modified: 18 Jul 2017 01:41

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Contributors

Author: L. Richeldi
Author: M. Mariani
Author: M. Losi
Author: F. Maselli
Author: L. Corbetta
Author: C. Buonsanti
Author: M. Colonna
Author: F. Sinigaglia
Author: P. Panina-Bordignon
Author: L.M. Fabbri

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