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[Screening of latent tuberculosis infection in health care workers by QuantiFERON-TB and tuberculin skin test]

[Screening of latent tuberculosis infection in health care workers by QuantiFERON-TB and tuberculin skin test]
[Screening of latent tuberculosis infection in health care workers by QuantiFERON-TB and tuberculin skin test]
Recent guidelines (MMWR 2005) recommend the use of QuantiFERON-TB (QFT-TB) as an alternative to the tuberculin skin test (TST) for the screening of latent tuberculosis infection (LTBI) in health care workers (HCWs).

MATERIALS AND METHODS: 590 HCWs were screened for LTBI by TST and QFT-TB. Results were compared with risk factors for LTBI, determined by questionnaires.

RESULTS: Both tests were significantly associated with non-Italian nationality [TCT (OR = 9.17), QFT-TB (OR = 3.65)], age > or = 45 years old [TCT (OR = 1.81), QFT-TB (OR = 2.36)], history of household contacts [TCT (OR = 2.65), QFT-TB (OR = 3.37], occupational exposure to tuberculosis (TB) patients [TCT (OR = 2.14), QFT-TB (OR = 1.93)]. 55 cases were discordant (28 QFT-TB-negatives/TCT-positives; 27 QFT-TB-positives/TCT-negatives). Both tests were not associated with workplace risk factors or TB risk level assessed in different hospital units.

CONCLUSIONS: In HCWs employed in a low TB incidence area both QFT-TB and TCT were more associated with non occupational risk factors (nationality, age, household contacts) than with main determinants of workplace risk for LTBI.
0391-9889
406-407
Ciaschetti, A.
06aa1cc3-f503-474b-bca7-d0dab13d7f47
Franchi, A.
c544befc-3c5c-4799-9a37-c720fdda7a7d
Richeldi, L.
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26
Rumpianesi, F.
ff04419f-0660-4845-bd4c-bf81fc66d760
Meacci, M.
ee7c7cab-30bf-4588-9fe6-eccbd9db7934
Valente, A.
1ac9a924-576d-47e6-ab78-5f4f5ab45a02
Franco, G.
88cb0a8c-716e-443a-af61-d6fa5b7a9036
Ciaschetti, A.
06aa1cc3-f503-474b-bca7-d0dab13d7f47
Franchi, A.
c544befc-3c5c-4799-9a37-c720fdda7a7d
Richeldi, L.
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26
Rumpianesi, F.
ff04419f-0660-4845-bd4c-bf81fc66d760
Meacci, M.
ee7c7cab-30bf-4588-9fe6-eccbd9db7934
Valente, A.
1ac9a924-576d-47e6-ab78-5f4f5ab45a02
Franco, G.
88cb0a8c-716e-443a-af61-d6fa5b7a9036

Ciaschetti, A., Franchi, A., Richeldi, L., Rumpianesi, F., Meacci, M., Valente, A. and Franco, G. (2007) [Screening of latent tuberculosis infection in health care workers by QuantiFERON-TB and tuberculin skin test]. Giornale Italiano di Medicina del Lavoro ed Ergonomia, 29, supplement 3, 406-407. (PMID:18409747)

Record type: Article

Abstract

Recent guidelines (MMWR 2005) recommend the use of QuantiFERON-TB (QFT-TB) as an alternative to the tuberculin skin test (TST) for the screening of latent tuberculosis infection (LTBI) in health care workers (HCWs).

MATERIALS AND METHODS: 590 HCWs were screened for LTBI by TST and QFT-TB. Results were compared with risk factors for LTBI, determined by questionnaires.

RESULTS: Both tests were significantly associated with non-Italian nationality [TCT (OR = 9.17), QFT-TB (OR = 3.65)], age > or = 45 years old [TCT (OR = 1.81), QFT-TB (OR = 2.36)], history of household contacts [TCT (OR = 2.65), QFT-TB (OR = 3.37], occupational exposure to tuberculosis (TB) patients [TCT (OR = 2.14), QFT-TB (OR = 1.93)]. 55 cases were discordant (28 QFT-TB-negatives/TCT-positives; 27 QFT-TB-positives/TCT-negatives). Both tests were not associated with workplace risk factors or TB risk level assessed in different hospital units.

CONCLUSIONS: In HCWs employed in a low TB incidence area both QFT-TB and TCT were more associated with non occupational risk factors (nationality, age, household contacts) than with main determinants of workplace risk for LTBI.

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More information

Published date: July 2007
Additional Information: Article in Italian
Organisations: Clinical & Experimental Sciences

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Local EPrints ID: 368967
URI: https://eprints.soton.ac.uk/id/eprint/368967
ISSN: 0391-9889
PURE UUID: 356977ac-6577-41a8-b8f4-7030bb4348ef

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Date deposited: 10 Oct 2014 13:56
Last modified: 18 Jul 2017 01:41

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