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Neglected evidence in idiopathic pulmonary fibrosis and the importance of early diagnosis and treatment

Neglected evidence in idiopathic pulmonary fibrosis and the importance of early diagnosis and treatment
Neglected evidence in idiopathic pulmonary fibrosis and the importance of early diagnosis and treatment
In idiopathic pulmonary fibrosis (IPF), some facts or concepts based on substantial evidence, whilst implicit for learned subspecialists, have previously been neglected and/or not explicitly formulated or made accessible to a wider audience. IPF is strongly associated with cigarette smoking and is predominantly a disease of ageing. However, its cause(s) remain elusive and, thus, it is one of the most challenging diseases for the development of novel effective and safe therapies. With the approval of pirfenidone for patients with mild-to-moderate IPF, an earlier diagnosis of IPF is a prerequisite for earlier treatment and, potentially, improvement of the long-term clinical outcome of this progressive and ultimately fatal disease. An earlier diagnosis may be achieved in IPF by promoting thin-slice chest high-resolution computed tomography screening of interstitial lung disease as a "by-product" of large-scale lung cancer screening strategies in smokers, but other techniques, which have been neglected in the past, are now available. Lung auscultation and early identification of "velcro" crackles has been proposed as a key component of early diagnosis of IPF. An ongoing study is exploring correlations between lung sounds on auscultation obtained using electronic stethoscopes and high-resolution computed tomography patterns.
0905-9180
106-110
Cottin, Vincent
e73bdd1a-00d4-4cd2-9a0b-a796c361ca84
Richeldi, Luca
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26
Cottin, Vincent
e73bdd1a-00d4-4cd2-9a0b-a796c361ca84
Richeldi, Luca
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26

Cottin, Vincent and Richeldi, Luca (2014) Neglected evidence in idiopathic pulmonary fibrosis and the importance of early diagnosis and treatment. European Respiratory Review, 23 (131), 106-110. (doi:10.1183/09059180.00008613). (PMID:24591667)

Record type: Article

Abstract

In idiopathic pulmonary fibrosis (IPF), some facts or concepts based on substantial evidence, whilst implicit for learned subspecialists, have previously been neglected and/or not explicitly formulated or made accessible to a wider audience. IPF is strongly associated with cigarette smoking and is predominantly a disease of ageing. However, its cause(s) remain elusive and, thus, it is one of the most challenging diseases for the development of novel effective and safe therapies. With the approval of pirfenidone for patients with mild-to-moderate IPF, an earlier diagnosis of IPF is a prerequisite for earlier treatment and, potentially, improvement of the long-term clinical outcome of this progressive and ultimately fatal disease. An earlier diagnosis may be achieved in IPF by promoting thin-slice chest high-resolution computed tomography screening of interstitial lung disease as a "by-product" of large-scale lung cancer screening strategies in smokers, but other techniques, which have been neglected in the past, are now available. Lung auscultation and early identification of "velcro" crackles has been proposed as a key component of early diagnosis of IPF. An ongoing study is exploring correlations between lung sounds on auscultation obtained using electronic stethoscopes and high-resolution computed tomography patterns.

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More information

e-pub ahead of print date: 28 February 2014
Published date: 1 March 2014
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 369099
URI: https://eprints.soton.ac.uk/id/eprint/369099
ISSN: 0905-9180
PURE UUID: 6a1ecb41-1169-4619-a990-df10dc749092

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Date deposited: 24 Sep 2014 12:48
Last modified: 08 Jun 2018 16:32

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Contributors

Author: Vincent Cottin
Author: Luca Richeldi

University divisions

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