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Cross-disciplinary collaboration in connective tissue disease-related lung disease

Cross-disciplinary collaboration in connective tissue disease-related lung disease
Cross-disciplinary collaboration in connective tissue disease-related lung disease
Lung disease is a common manifestation of connective tissue disease (CTD) and is associated with significant morbidity and mortality. The evaluation of lung disease, and interstitial lung disease (ILD) in particular, in patients with CTD is complex because of the heterogeneity of the CTDs, the varied types and degrees of severity of ILD encountered, and because ILD can be identified at any point in time in these patients. Cross-disciplinary, thorough evaluations are needed when CTD patients develop ILD or when evaluating ILD patients for the presence of occult CTD. Determining that ILD is associated with an established CTD requires the exclusion of alternative etiologies, and thorough assessments of the clinical features of both the CTD and ILD. The detection of occult CTD in patients with "idiopathic" ILD requires careful attention to the demographic profile, historical clues, subtle physical examination findings, specific autoantibody positivity, radiological and histopathological features, and can be optimized by a multidisciplinary approach that includes rheumatological collaboration. Not all patients with CTD-associated ILD require pharmacological therapy, and management decisions should consider pace and severity of the disease, intra- and extrathoracic features of activity and can be optimized by cross-disciplinary collaboration.
1069-3424
159-165
Fischer, Aryeh
86fef1cc-8833-4f34-a864-2f1ba23a9d15
Richeldi, Luca
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26
Fischer, Aryeh
86fef1cc-8833-4f34-a864-2f1ba23a9d15
Richeldi, Luca
47177d9c-731a-49a1-9cc6-4ac8f6bbbf26

Fischer, Aryeh and Richeldi, Luca (2014) Cross-disciplinary collaboration in connective tissue disease-related lung disease. Seminars in Respiratory and Critical Care Medicine, 35 (2), 159-165. (doi:10.1055/s-0034-1371530). (PMID:24668532)

Record type: Article

Abstract

Lung disease is a common manifestation of connective tissue disease (CTD) and is associated with significant morbidity and mortality. The evaluation of lung disease, and interstitial lung disease (ILD) in particular, in patients with CTD is complex because of the heterogeneity of the CTDs, the varied types and degrees of severity of ILD encountered, and because ILD can be identified at any point in time in these patients. Cross-disciplinary, thorough evaluations are needed when CTD patients develop ILD or when evaluating ILD patients for the presence of occult CTD. Determining that ILD is associated with an established CTD requires the exclusion of alternative etiologies, and thorough assessments of the clinical features of both the CTD and ILD. The detection of occult CTD in patients with "idiopathic" ILD requires careful attention to the demographic profile, historical clues, subtle physical examination findings, specific autoantibody positivity, radiological and histopathological features, and can be optimized by a multidisciplinary approach that includes rheumatological collaboration. Not all patients with CTD-associated ILD require pharmacological therapy, and management decisions should consider pace and severity of the disease, intra- and extrathoracic features of activity and can be optimized by cross-disciplinary collaboration.

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More information

e-pub ahead of print date: 25 March 2014
Published date: 1 April 2014
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 369101
URI: https://eprints.soton.ac.uk/id/eprint/369101
ISSN: 1069-3424
PURE UUID: 72d685f1-06c4-473e-9281-7dface61b380

Catalogue record

Date deposited: 24 Sep 2014 12:52
Last modified: 15 Jul 2019 21:44

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