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Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women

Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women
Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women
Background: Short-term zidovudine monotherapy (ZDVm) remains an option for some pregnant HIV-positive women not requiring treatment for their own health but may affect treatment responses once antiretroviral therapy (ART) is subsequently started.

Methods: Data were obtained by linking two UK studies: the UK Collaborative HIV Cohort (UK CHIC) study and the National Study of HIV in Pregnancy and Childhood (NSHPC). Treatment responses were assessed for 2028 women initiating ART at least one year after HIV-diagnosis. Outcomes were compared using logistic regression, proportional hazards regression or linear regression.

Results: In adjusted analyses, ART-naïve (n?=?1937) and ZDVm-experienced (n?=?91) women had similar increases in CD4 count and a similar proportion achieving virological suppression; both groups had a low risk of AIDS.

Conclusions: In this setting, antenatal ZDVm exposure did not adversely impact on outcomes once ART was initiated for the woman's health.
1471-2334
127
Huntington, Susie
f26b3078-97d6-4a2f-9dbd-f052ad46d871
Thorne, Claire
6c6f09c0-d10c-4002-bc83-fc1ce421d444
Anderson, Jane
44441d47-d795-4a2c-94bb-aa890e40e1cd
Newell, Marie-Louise
c6ff99dd-c23b-4fef-a846-a221fe2522b3
Taylor, Graham P
aacd657b-fb42-4c1f-8b18-bd0bdea2c178
Pillay, Deenan
9b4da6c6-2220-4c60-aaca-f0f1a37c2ca8
Hill, Teresa
2b7c041a-e04c-4ab8-af66-8d16e64efd96
Tookey, Pat
7093ae82-efaf-434f-bc4c-4ddd73aeec00
Sabin, Caroline
e84906f3-bc18-42fa-9725-a0279181c83f
Huntington, Susie
f26b3078-97d6-4a2f-9dbd-f052ad46d871
Thorne, Claire
6c6f09c0-d10c-4002-bc83-fc1ce421d444
Anderson, Jane
44441d47-d795-4a2c-94bb-aa890e40e1cd
Newell, Marie-Louise
c6ff99dd-c23b-4fef-a846-a221fe2522b3
Taylor, Graham P
aacd657b-fb42-4c1f-8b18-bd0bdea2c178
Pillay, Deenan
9b4da6c6-2220-4c60-aaca-f0f1a37c2ca8
Hill, Teresa
2b7c041a-e04c-4ab8-af66-8d16e64efd96
Tookey, Pat
7093ae82-efaf-434f-bc4c-4ddd73aeec00
Sabin, Caroline
e84906f3-bc18-42fa-9725-a0279181c83f

Huntington, Susie, Thorne, Claire, Anderson, Jane, Newell, Marie-Louise, Taylor, Graham P, Pillay, Deenan, Hill, Teresa, Tookey, Pat and Sabin, Caroline (2014) Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women. BMC Infectious Diseases, 14 (1), 127. (doi:10.1186/1471-2334-14-127). (PMID:24593018)

Record type: Article

Abstract

Background: Short-term zidovudine monotherapy (ZDVm) remains an option for some pregnant HIV-positive women not requiring treatment for their own health but may affect treatment responses once antiretroviral therapy (ART) is subsequently started.

Methods: Data were obtained by linking two UK studies: the UK Collaborative HIV Cohort (UK CHIC) study and the National Study of HIV in Pregnancy and Childhood (NSHPC). Treatment responses were assessed for 2028 women initiating ART at least one year after HIV-diagnosis. Outcomes were compared using logistic regression, proportional hazards regression or linear regression.

Results: In adjusted analyses, ART-naïve (n?=?1937) and ZDVm-experienced (n?=?91) women had similar increases in CD4 count and a similar proportion achieving virological suppression; both groups had a low risk of AIDS.

Conclusions: In this setting, antenatal ZDVm exposure did not adversely impact on outcomes once ART was initiated for the woman's health.

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More information

Published date: 4 March 2014
Additional Information: © 2014 Huntington et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 369267
URI: http://eprints.soton.ac.uk/id/eprint/369267
ISSN: 1471-2334
PURE UUID: 6d80e294-49ae-4bdb-acbc-a7a777c4b96a
ORCID for Marie-Louise Newell: ORCID iD orcid.org/0000-0002-1074-7699

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Date deposited: 23 Sep 2014 10:07
Last modified: 15 Mar 2024 03:47

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Contributors

Author: Susie Huntington
Author: Claire Thorne
Author: Jane Anderson
Author: Graham P Taylor
Author: Deenan Pillay
Author: Teresa Hill
Author: Pat Tookey
Author: Caroline Sabin

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