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Intrahepatic lipid content and insulin resistance are more strongly associated with impaired NEFA suppression after oral glucose loading than with fasting NEFA levels in healthy older individuals

Intrahepatic lipid content and insulin resistance are more strongly associated with impaired NEFA suppression after oral glucose loading than with fasting NEFA levels in healthy older individuals
Intrahepatic lipid content and insulin resistance are more strongly associated with impaired NEFA suppression after oral glucose loading than with fasting NEFA levels in healthy older individuals
Introduction. The mechanisms underlying the association between insulin resistance and intrahepatic lipid (IHL) accumulation are not completely understood. We sought to determine whether this association was explained by differences in fasting non-esterified fatty acid (NEFA) levels and/or NEFA suppression after oral glucose loading.

Materials and Methods. We performed a cross-sectional analysis of 70 healthy participants in the Hertfordshire Physical Activity Trial (39 males, age 71.3 ± 2.4 years) who underwent oral glucose tolerance testing with glucose, insulin, and NEFA levels measured over two hours. IHL was quantified with magnetic resonance spectroscopy. Insulin sensitivity was measured with the oral glucose insulin sensitivity (OGIS) model, the leptin: adiponectin ratio (LAR), and the homeostasis model assessment (HOMA).

Results. Measures of insulin sensitivity were not associated with fasting NEFA levels, but OGIS was strongly associated with NEFA suppression at 30 minutes and strongly inversely associated with IHL. Moreover, LAR was strongly inversely associated with NEFA suppression and strongly associated with IHL. This latter association (beta = 1.11 [1.01, 1.21], P = 0.026) was explained by reduced NEFA suppression (P = 0.24 after adjustment).

Conclusions. Impaired postprandial NEFA suppression, but not fasting NEFA, contributes to the strong and well-established association between whole body insulin resistance and liver fat accumulation.
1687-8337
[7pp]
Finucane, Francis M.
18a42c88-6fec-44b6-a10e-c8fdb32e62a9
Sharp, Stephen J.
65e1326f-97f8-4654-b75c-15d046f00532
Hatunic, Mensud
a9dc8be9-9a76-4886-83e8-c37a030d725d
Sleigh, Alison
b948a8de-00fb-436f-ace2-aa2310964c71
De Lucia Rolfe, Ema
79cd36f9-4055-43d9-9f98-c5903ec23a59
Sayer, Avan Aihie
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Griffin, Simon J.
1f8d5095-3c10-4973-a2c4-84ce6415d118
Savage, David B.
5c85179d-04e7-4be9-a1d9-cc127234d3f3
Wareham, Nicholas J.
bbc18cd9-3512-4ca6-806c-75c9a01e5adf
Finucane, Francis M.
18a42c88-6fec-44b6-a10e-c8fdb32e62a9
Sharp, Stephen J.
65e1326f-97f8-4654-b75c-15d046f00532
Hatunic, Mensud
a9dc8be9-9a76-4886-83e8-c37a030d725d
Sleigh, Alison
b948a8de-00fb-436f-ace2-aa2310964c71
De Lucia Rolfe, Ema
79cd36f9-4055-43d9-9f98-c5903ec23a59
Sayer, Avan Aihie
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Griffin, Simon J.
1f8d5095-3c10-4973-a2c4-84ce6415d118
Savage, David B.
5c85179d-04e7-4be9-a1d9-cc127234d3f3
Wareham, Nicholas J.
bbc18cd9-3512-4ca6-806c-75c9a01e5adf

Finucane, Francis M., Sharp, Stephen J., Hatunic, Mensud, Sleigh, Alison, De Lucia Rolfe, Ema, Sayer, Avan Aihie, Cooper, Cyrus, Griffin, Simon J., Savage, David B. and Wareham, Nicholas J. (2013) Intrahepatic lipid content and insulin resistance are more strongly associated with impaired NEFA suppression after oral glucose loading than with fasting NEFA levels in healthy older individuals. International Journal of Endocrinology, 2013, [7pp]. (doi:10.1155/2013/870487).

Record type: Article

Abstract

Introduction. The mechanisms underlying the association between insulin resistance and intrahepatic lipid (IHL) accumulation are not completely understood. We sought to determine whether this association was explained by differences in fasting non-esterified fatty acid (NEFA) levels and/or NEFA suppression after oral glucose loading.

Materials and Methods. We performed a cross-sectional analysis of 70 healthy participants in the Hertfordshire Physical Activity Trial (39 males, age 71.3 ± 2.4 years) who underwent oral glucose tolerance testing with glucose, insulin, and NEFA levels measured over two hours. IHL was quantified with magnetic resonance spectroscopy. Insulin sensitivity was measured with the oral glucose insulin sensitivity (OGIS) model, the leptin: adiponectin ratio (LAR), and the homeostasis model assessment (HOMA).

Results. Measures of insulin sensitivity were not associated with fasting NEFA levels, but OGIS was strongly associated with NEFA suppression at 30 minutes and strongly inversely associated with IHL. Moreover, LAR was strongly inversely associated with NEFA suppression and strongly associated with IHL. This latter association (beta = 1.11 [1.01, 1.21], P = 0.026) was explained by reduced NEFA suppression (P = 0.24 after adjustment).

Conclusions. Impaired postprandial NEFA suppression, but not fasting NEFA, contributes to the strong and well-established association between whole body insulin resistance and liver fat accumulation.

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More information

Published date: 2013
Additional Information: Copyright © 2013 Francis M. Finucane et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 369309
URI: http://eprints.soton.ac.uk/id/eprint/369309
ISSN: 1687-8337
PURE UUID: e2f0e4c1-c55a-41ad-af5d-16645b004fa5
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 23 Sep 2014 13:10
Last modified: 20 Jul 2019 01:14

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Contributors

Author: Francis M. Finucane
Author: Stephen J. Sharp
Author: Mensud Hatunic
Author: Alison Sleigh
Author: Ema De Lucia Rolfe
Author: Avan Aihie Sayer
Author: Cyrus Cooper ORCID iD
Author: Simon J. Griffin
Author: David B. Savage
Author: Nicholas J. Wareham

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