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Maternal diet, oocyte nutrition and metabolism and offspring health

Maternal diet, oocyte nutrition and metabolism and offspring health
Maternal diet, oocyte nutrition and metabolism and offspring health
Malnutrition (i.e. undernutrition and overnutrition) is a world-wide phenomenon that can affect mammalian oocyte developmental competence following fertilization, compromising the establishment of pregnancy. However, live birth is usually possible during maternal malnutrition even in extremes cases of undernutrition (i.e. anorexia nervosa) and overnutrition (i.e. morbid obesity). Several epidemiological and clinical studies in humans and experimental animal models have demonstrated that in utero development under nutritional stress can program the development of non-communicable diseases (NCD) in adult life (e.g. diabetes, metabolic syndrome). Of further significance is the fact that malnutrition can also program the development of NCD in adulthood via changes on oocyte physiology before conception. This chapter focuses on the available evidence supporting this latter hypothesis
978-0-85729-825-6
329-351
Springer
Velazquez, M.A.
706e7de5-8cdb-4f2b-b47d-128166bdbea4
Fleming, T.P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03
Velazquez, M.A.
706e7de5-8cdb-4f2b-b47d-128166bdbea4
Fleming, T.P.
2abf761a-e5a1-4fa7-a2c8-12e32d5d4c03

Velazquez, M.A. and Fleming, T.P. (2013) Maternal diet, oocyte nutrition and metabolism and offspring health. In, Oogenesis. New York, US. Springer, pp. 329-351. (doi:10.1007/978-0-85729-826-3).

Record type: Book Section

Abstract

Malnutrition (i.e. undernutrition and overnutrition) is a world-wide phenomenon that can affect mammalian oocyte developmental competence following fertilization, compromising the establishment of pregnancy. However, live birth is usually possible during maternal malnutrition even in extremes cases of undernutrition (i.e. anorexia nervosa) and overnutrition (i.e. morbid obesity). Several epidemiological and clinical studies in humans and experimental animal models have demonstrated that in utero development under nutritional stress can program the development of non-communicable diseases (NCD) in adult life (e.g. diabetes, metabolic syndrome). Of further significance is the fact that malnutrition can also program the development of NCD in adulthood via changes on oocyte physiology before conception. This chapter focuses on the available evidence supporting this latter hypothesis

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Published date: 2013
Organisations: Centre for Biological Sciences

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Local EPrints ID: 369437
URI: http://eprints.soton.ac.uk/id/eprint/369437
ISBN: 978-0-85729-825-6
PURE UUID: b5c504af-0e42-4ade-8d34-ae178c0a3e6f

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Date deposited: 16 Oct 2014 08:09
Last modified: 15 Jul 2019 21:43

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