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WAPing out pathogens and disease in the mucosa: roles for SLPI and Trappin-2

WAPing out pathogens and disease in the mucosa: roles for SLPI and Trappin-2
WAPing out pathogens and disease in the mucosa: roles for SLPI and Trappin-2
The interface between the external environment and the body’s internal structures is defined by the mucosal tissue and the viscous lining fluid that is responsible for maintaining its integrity and protecting internal structures from damage or infection. Human mucosal fluids include seminal fluid, cervical mucus, bronchial and nasal secretions and tears whose composition is particularly complicated. This review will focus on just two related molecules that are present in the mucosal lining fluid, namely, trappin-2 and secretory leucocyte protease inhibitor (SLPI), that are responsible for many of the homeostatic and host defence functions of these uniquely situated viscous sols. This review will focus on our increasing understanding of these two molecules from a simple role as local antibiotics that respond to pathogen invasion to major orchestrators of cellular interplays, host defence mechanisms and immune homeostasis.
978-3-0348-0540-7
141-166
Springer
Wilkinson, Thomas S.
7eded9dd-9a7d-4d24-9d7e-121324bb456c
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
Sallenave, Jean-Michel
dbe1dd6a-e3df-48dc-946c-d874b140460f
Hiemstra, Pieter S.
Zaat, Sebastian A.J.
Wilkinson, Thomas S.
7eded9dd-9a7d-4d24-9d7e-121324bb456c
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
Sallenave, Jean-Michel
dbe1dd6a-e3df-48dc-946c-d874b140460f
Hiemstra, Pieter S.
Zaat, Sebastian A.J.

Wilkinson, Thomas S., Roghanian, Ali and Sallenave, Jean-Michel (2012) WAPing out pathogens and disease in the mucosa: roles for SLPI and Trappin-2. In, Hiemstra, Pieter S. and Zaat, Sebastian A.J. (eds.) Antimicrobial Peptides and Innate Immunity. (Progress in Inflammation Research, , (doi:10.1007/978-3-0348-0541-4_6)) Basel, CH. Springer, pp. 141-166. (doi:10.1007/978-3-0348-0541-4_6).

Record type: Book Section

Abstract

The interface between the external environment and the body’s internal structures is defined by the mucosal tissue and the viscous lining fluid that is responsible for maintaining its integrity and protecting internal structures from damage or infection. Human mucosal fluids include seminal fluid, cervical mucus, bronchial and nasal secretions and tears whose composition is particularly complicated. This review will focus on just two related molecules that are present in the mucosal lining fluid, namely, trappin-2 and secretory leucocyte protease inhibitor (SLPI), that are responsible for many of the homeostatic and host defence functions of these uniquely situated viscous sols. This review will focus on our increasing understanding of these two molecules from a simple role as local antibiotics that respond to pathogen invasion to major orchestrators of cellular interplays, host defence mechanisms and immune homeostasis.

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Published date: 10 December 2012
Organisations: Cancer Sciences

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Local EPrints ID: 369603
URI: https://eprints.soton.ac.uk/id/eprint/369603
ISBN: 978-3-0348-0540-7
PURE UUID: 45a17d6e-d366-4de0-93ab-510f6acd2d33

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Date deposited: 02 Oct 2014 11:16
Last modified: 17 Jul 2017 21:56

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Contributors

Author: Thomas S. Wilkinson
Author: Ali Roghanian
Author: Jean-Michel Sallenave
Editor: Pieter S. Hiemstra
Editor: Sebastian A.J. Zaat

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