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SLPI and elafin: one glove, many fingers.

SLPI and elafin: one glove, many fingers.
SLPI and elafin: one glove, many fingers.
Elafin and SLPI (secretory leucocyte protease inhibitor) have multiple important roles both in normal homoeostasis and at sites of inflammation. These include antiprotease and antimicrobial activity as well as modulation of the response to LPS (lipopolysaccharide) stimulation. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites, and have been shown to be modulated in multiple pathological conditions. We believe that elafin and SLPI are important molecules in the controlled functioning of the innate immune system, and may have further importance in the integration of this system with the adaptive immune response. Recent interest has focused on the influence of inflamed tissues on the recruitment and phenotypic modulation of cells of the adaptive immune system and, indeed, the local production of elafin and SLPI indicate that they are ideally placed in this regard. Functionally related proteins, such as the defensins and cathelicidins, have been shown to have direct effects upon dendritic cells with potential alteration of their phenotype towards type I or II immune responses. This review addresses the multiple functions of elafin and SLPI in the inflammatory response and discusses further their roles in the development of the adaptive immune response.
0143-5221
21-35
Williams, Steven E.
1b6f1255-2697-46f1-865b-78ce688c012e
Brown, Thomas I.
e80f4fb3-891c-496c-a42c-1824f41672de
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
Sallenave, Jean-Michel
dbe1dd6a-e3df-48dc-946c-d874b140460f
Williams, Steven E.
1b6f1255-2697-46f1-865b-78ce688c012e
Brown, Thomas I.
e80f4fb3-891c-496c-a42c-1824f41672de
Roghanian, Ali
e2b032c2-60a0-4522-a3d8-56a768792f36
Sallenave, Jean-Michel
dbe1dd6a-e3df-48dc-946c-d874b140460f

Williams, Steven E., Brown, Thomas I., Roghanian, Ali and Sallenave, Jean-Michel (2006) SLPI and elafin: one glove, many fingers. Clinical Science, 110 (1), 21-35. (doi:10.1042/CS20050115). (PMID:16336202)

Record type: Article

Abstract

Elafin and SLPI (secretory leucocyte protease inhibitor) have multiple important roles both in normal homoeostasis and at sites of inflammation. These include antiprotease and antimicrobial activity as well as modulation of the response to LPS (lipopolysaccharide) stimulation. Elafin and SLPI are members of larger families of proteins secreted predominantly at mucosal sites, and have been shown to be modulated in multiple pathological conditions. We believe that elafin and SLPI are important molecules in the controlled functioning of the innate immune system, and may have further importance in the integration of this system with the adaptive immune response. Recent interest has focused on the influence of inflamed tissues on the recruitment and phenotypic modulation of cells of the adaptive immune system and, indeed, the local production of elafin and SLPI indicate that they are ideally placed in this regard. Functionally related proteins, such as the defensins and cathelicidins, have been shown to have direct effects upon dendritic cells with potential alteration of their phenotype towards type I or II immune responses. This review addresses the multiple functions of elafin and SLPI in the inflammatory response and discusses further their roles in the development of the adaptive immune response.

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More information

Published date: January 2006
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 369614
URI: http://eprints.soton.ac.uk/id/eprint/369614
ISSN: 0143-5221
PURE UUID: 7c15bc4d-7f73-45e3-a0f6-68b90e740207
ORCID for Ali Roghanian: ORCID iD orcid.org/0000-0003-1316-4218

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Date deposited: 02 Oct 2014 09:54
Last modified: 15 Mar 2024 03:34

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Contributors

Author: Steven E. Williams
Author: Thomas I. Brown
Author: Ali Roghanian ORCID iD
Author: Jean-Michel Sallenave

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