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New approaches to the treatment of biofilm-related infections

New approaches to the treatment of biofilm-related infections
New approaches to the treatment of biofilm-related infections
Bacteria causing chronic infections predominately grow as surface-attached, sessile communities known as biofilms. Biofilm-related infections including cystic fibrosis lung infection, chronic and recurrent otitis media, chronic wounds and implant- and catheter-associated infections, are a significant cause of morbidity and mortality and financial cost. Chronic biofilm-based infections are recalcitrant to conventional antibiotic therapy and are often unperturbed by host immune responses such as phagocytosis, despite a sustained presence of host inflammation.

The diagnosis of clinically important biofilm infections is often difficult as Koch's postulates are rarely met. If treatment is required, surgical removal of the infected implant, or debridement of wound or bone, is the most efficient means of eradicating a clinically significant biofilm. New approaches to treatment are under investigation
0163-4453
1-6
Wilkins, M.
6a0d2178-c383-4041-86f1-937e243559bb
Hall-Stoodley, L.
94ebdc00-b549-4488-b15f-5310fb965f5b
Allan, R.N.
b4579866-5280-4ed9-b54f-a96ef761bfc9
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Allan, Raymond
390a7d0a-38e1-410a-8dfe-c8ef8408f5e1
Wilkins, M.
6a0d2178-c383-4041-86f1-937e243559bb
Hall-Stoodley, L.
94ebdc00-b549-4488-b15f-5310fb965f5b
Allan, R.N.
b4579866-5280-4ed9-b54f-a96ef761bfc9
Faust, S.N.
f97df780-9f9b-418e-b349-7adf63e150c1
Allan, Raymond
390a7d0a-38e1-410a-8dfe-c8ef8408f5e1

Wilkins, M., Hall-Stoodley, L., Allan, R.N., Faust, S.N. and Allan, Raymond (2014) New approaches to the treatment of biofilm-related infections. Journal of Infection, 1-6. (doi:10.1016/j.jinf.2014.07.014). (PMID:25240819)

Record type: Review

Abstract

Bacteria causing chronic infections predominately grow as surface-attached, sessile communities known as biofilms. Biofilm-related infections including cystic fibrosis lung infection, chronic and recurrent otitis media, chronic wounds and implant- and catheter-associated infections, are a significant cause of morbidity and mortality and financial cost. Chronic biofilm-based infections are recalcitrant to conventional antibiotic therapy and are often unperturbed by host immune responses such as phagocytosis, despite a sustained presence of host inflammation.

The diagnosis of clinically important biofilm infections is often difficult as Koch's postulates are rarely met. If treatment is required, surgical removal of the infected implant, or debridement of wound or bone, is the most efficient means of eradicating a clinically significant biofilm. New approaches to treatment are under investigation

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More information

e-pub ahead of print date: 17 September 2014
Organisations: Faculty of Medicine, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 370143
URI: https://eprints.soton.ac.uk/id/eprint/370143
ISSN: 0163-4453
PURE UUID: a2c2bf62-821d-475e-a9cd-053aeb071ca1
ORCID for S.N. Faust: ORCID iD orcid.org/0000-0003-3410-7642

Catalogue record

Date deposited: 23 Oct 2014 14:02
Last modified: 06 Jun 2018 12:40

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