The University of Southampton
University of Southampton Institutional Repository

Osteoporosis: a lifecourse approach

Osteoporosis: a lifecourse approach
Osteoporosis: a lifecourse approach
It is becoming increasingly apparent that the risk of developing osteoporosis is accrued throughout the entire lifecourse, even from as early as conception. Thus early growth is associated with bone mass at peak and in older age, and risk of hip fracture. Novel findings from mother-offspring cohorts have yielded greater understanding of relationships between patterns of intrauterine and postnatal growth in the context of later bone development. Study of biological samples from these populations has helped characterize potential mechanistic underpinnings, such as epigenetic processes. Global policy has recognized the importance of early growth and nutrition to the risk of developing adult chronic noncommunicable diseases such as osteoporosis; testing of pregnancy interventions aimed at optimizing offspring bone health is now underway. It is hoped that through such programs, novel public health strategies may be established with the ultimate goal of reducing the burden of osteoporotic fracture in older age.
0884-0431
1917-1925
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6

Harvey, N.C., Dennison, E.M. and Cooper, C. (2014) Osteoporosis: a lifecourse approach. Journal of Bone and Mineral Research, 29 (9), 1917-1925. (doi:10.1002/jbmr.2286). (PMID:24861883)

Record type: Article

Abstract

It is becoming increasingly apparent that the risk of developing osteoporosis is accrued throughout the entire lifecourse, even from as early as conception. Thus early growth is associated with bone mass at peak and in older age, and risk of hip fracture. Novel findings from mother-offspring cohorts have yielded greater understanding of relationships between patterns of intrauterine and postnatal growth in the context of later bone development. Study of biological samples from these populations has helped characterize potential mechanistic underpinnings, such as epigenetic processes. Global policy has recognized the importance of early growth and nutrition to the risk of developing adult chronic noncommunicable diseases such as osteoporosis; testing of pregnancy interventions aimed at optimizing offspring bone health is now underway. It is hoped that through such programs, novel public health strategies may be established with the ultimate goal of reducing the burden of osteoporotic fracture in older age.

This record has no associated files available for download.

More information

Published date: September 2014
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 370191
URI: http://eprints.soton.ac.uk/id/eprint/370191
ISSN: 0884-0431
PURE UUID: a43d12c5-e938-4fb3-8088-01953b279a83
ORCID for N.C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 27 Oct 2014 13:53
Last modified: 18 Mar 2024 02:58

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×